23 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (673 aa)
	IL27RA	Interleukin 27 receptor subunit alpha. (693 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	IGF2	Insulin like growth factor 2. (280 aa)
	TNFSF9	TNF superfamily member 9; Belongs to the tumor necrosis factor family. (250 aa)
	ENSFCAP00000031202	Uncharacterized protein. (94 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (330 aa)
	ENSFCAP00000030418	KH type-2 domain-containing protein. (147 aa)
	ENSFCAP00000030239	Uncharacterized protein. (145 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
	IL23A	Interleukin 23 subunit alpha. (196 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	IL2RA	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
	AGER	Advanced glycosylation end-product specific receptor. (492 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (347 aa)
	STAT5B	Signal transducer and activator of transcription. (786 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	HMGB1	ENSFCAP00000004183	ENSFCAP00000058007	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.727
ENSFCAP00000030239	RPS3	ENSFCAP00000030239	ENSFCAP00000011080	Uncharacterized protein.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.548
HMGB1	AGER	ENSFCAP00000058007	ENSFCAP00000004183	Uncharacterized protein.	Advanced glycosylation end-product specific receptor.	0.727
HMGB1	IL18	ENSFCAP00000058007	ENSFCAP00000027095	Uncharacterized protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.597
IGF2	IGFBP2	ENSFCAP00000033832	ENSFCAP00000030918	Insulin like growth factor 2.	Insulin like growth factor binding protein 2.	0.874
IGFBP2	IGF2	ENSFCAP00000030918	ENSFCAP00000033832	Insulin like growth factor binding protein 2.	Insulin like growth factor 2.	0.874
IL12B	IL12RB1	ENSFCAP00000026531	ENSFCAP00000062154	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family.	Interleukin 12 receptor subunit beta 1.	0.900
IL12B	IL23A	ENSFCAP00000026531	ENSFCAP00000011154	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family.	Interleukin 23 subunit alpha.	0.621
IL12B	IL2RA	ENSFCAP00000026531	ENSFCAP00000005380	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.732
IL12RB1	IL12B	ENSFCAP00000062154	ENSFCAP00000026531	Interleukin 12 receptor subunit beta 1.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family.	0.900
IL12RB1	IL2	ENSFCAP00000062154	ENSFCAP00000012696	Interleukin 12 receptor subunit beta 1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.748
IL12RB1	IL23A	ENSFCAP00000062154	ENSFCAP00000011154	Interleukin 12 receptor subunit beta 1.	Interleukin 23 subunit alpha.	0.985
IL12RB1	IL27RA	ENSFCAP00000062154	ENSFCAP00000061707	Interleukin 12 receptor subunit beta 1.	Interleukin 27 receptor subunit alpha.	0.727
IL12RB1	IL2RA	ENSFCAP00000062154	ENSFCAP00000005380	Interleukin 12 receptor subunit beta 1.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.462
IL12RB1	TNFSF9	ENSFCAP00000062154	ENSFCAP00000031348	Interleukin 12 receptor subunit beta 1.	TNF superfamily member 9; Belongs to the tumor necrosis factor family.	0.408
IL18	HMGB1	ENSFCAP00000027095	ENSFCAP00000058007	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Uncharacterized protein.	0.597
IL18	IL2	ENSFCAP00000027095	ENSFCAP00000012696	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.759
IL18	IL2RA	ENSFCAP00000027095	ENSFCAP00000005380	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.487
IL18	PYCARD	ENSFCAP00000027095	ENSFCAP00000051017	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	PYD and CARD domain containing.	0.982
IL2	IL12RB1	ENSFCAP00000012696	ENSFCAP00000062154	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	Interleukin 12 receptor subunit beta 1.	0.748