Your Input: | |
| | CYP1A2 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa) |
| | DHRS3 | Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa) |
| | HSD17B6 | Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (671 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa) |
| | SELENOM | Selenoprotein M. (141 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | STAT5B | Signal transducer and activator of transcription. (786 aa) |
| | GHRHR | Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa) |
| | REN | Renin; Belongs to the peptidase A1 family. (404 aa) |
| | RETSAT | Retinol saturase. (610 aa) |
| | PNPLA4 | Patatin like phospholipase domain containing 4. (290 aa) |
| | DHCR7 | 7-dehydrocholesterol reductase. (475 aa) |
| | PLB1 | Phospholipase B1. (1458 aa) |
| | DHRS13 | Dehydrogenase/reductase 13. (374 aa) |
| | AANAT | Aralkylamine N-acetyltransferase. (207 aa) |
| | RDH13 | Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | CORIN | Corin, serine peptidase. (1045 aa) |
| | PCSK1 | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | HSD17B8 | Hydroxysteroid 17-beta dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa) |
| | DHRS11 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (273 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | SLC5A5 | Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (642 aa) |
| | DUOX2 | Dual oxidase 2. (1547 aa) |
| | DUOX1 | Dual oxidase 1. (1551 aa) |
| | DGAT1 | O-acyltransferase. (493 aa) |
| | SULT1B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa) |
| | SLC16A2 | Solute carrier family 16 member 2. (623 aa) |
| | HSD17B4 | Hydroxysteroid 17-beta dehydrogenase 4. (736 aa) |
| | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | MEP1A | Metalloendopeptidase. (777 aa) |
| | RDH8 | Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | CRABP1 | Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa) |
| | DHRS7 | Dehydrogenase/reductase 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa) |
| | PCSK1N | Proprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa) |
| | TTR | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (146 aa) |
| | LOC101088802 | Uncharacterized protein. (944 aa) |
| | HSD17B1 | Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | CPE | Carboxypeptidase E. (476 aa) |
| | DEPDC1 | DEP domain containing 1. (811 aa) |
| | AKR1B1 | Aldo-keto reductase family 1 member B. (316 aa) |
| | TIPARP | TCDD inducible poly(ADP-ribose) polymerase. (692 aa) |
| | RDH5 | Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | ECE1 | Endothelin converting enzyme 1. (754 aa) |
| | RDH16 | Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa) |
| | CRYM | Crystallin mu. (314 aa) |
| | SULT1E1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (320 aa) |
| | CACNA1H | Calcium voltage-gated channel subunit alpha1 H. (2240 aa) |
| | CPQ | Carboxypeptidase Q. (472 aa) |
| | GCNT4 | Glucosaminyl (N-acetyl) transferase 4. (470 aa) |
| | UGT1A | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa) |
| | LIPE | Lipase E, hormone sensitive type. (772 aa) |
| | IDE | Insulin degrading enzyme. (1219 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | PDP | Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa) |
| | LOC101100805 | PKS_ER domain-containing protein. (381 aa) |
| | CEL | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (690 aa) |
| | HSD17B7 | Hydroxysteroid 17-beta dehydrogenase 7. (331 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | FOXA1 | Forkhead box A1. (536 aa) |
| | DIO1 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. (244 aa) |
| | AFP | Alpha fetoprotein. (609 aa) |
| | LOC101100387 | PKS_ER domain-containing protein. (375 aa) |
| | PNPLA2 | Patatin like phospholipase domain containing 2. (486 aa) |
| | LRAT | Lecithin retinol acyltransferase. (484 aa) |
| | ASMT | Acetylserotonin O-methyltransferase. (394 aa) |
| | CHST10 | Carbohydrate sulfotransferase. (381 aa) |
| | HSD3B2 | 3 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family. (373 aa) |
| | TPO | Thyroid peroxidase. (698 aa) |
| | CGA | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (152 aa) |
| | LOC101086557 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (276 aa) |
| | DIO2 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (132 aa) |
| | ECE2 | Endothelin converting enzyme 2. (798 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | SDR9C7 | Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa) |
| | TG | Thyroglobulin. (2759 aa) |
| | DHRS9 | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | FDX1 | Ferredoxin 1. (186 aa) |
| | DHRS2 | Dehydrogenase/reductase 2. (281 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (333 aa) |
| | LOC101088902 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa) |
| | CYP3A131 | Uncharacterized protein. (503 aa) |
| | PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2. (620 aa) |
| | NR5A2 | Nuclear receptor subfamily 5 group A member 2. (541 aa) |
| | LOC101094201 | SCHIP-1 domain-containing protein. (489 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | YIPF5 | Protein YIPF. (257 aa) |
| | PCSK6 | Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (963 aa) |
| | PCSK5 | Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1857 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | SPP1 | Secreted phosphoprotein 1. (299 aa) |
| | IYD | Iodotyrosine deiodinase. (289 aa) |
| | SCG5 | Secretogranin V. (290 aa) |
| | PRLHR | Prolactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (437 aa) |
| | NR5A1 | Nuclear receptor subfamily 5 group A member 1. (461 aa) |
| | PCSK4 | Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (825 aa) |
| | LOC101097790 | Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa) |
| | DDO | D-aspartate oxidase. (400 aa) |
| | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa) |
| | MME | Membrane metalloendopeptidase. (749 aa) |
| | PCSK2 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (638 aa) |
| | HSD17B2 | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (269 aa) |
| | CYP3A132 | Uncharacterized protein. (508 aa) |
| | CHST8 | Carbohydrate sulfotransferase. (668 aa) |
| | DISP1 | Dispatched RND transporter family member 1. (1508 aa) |
| | ADH4 | Alcohol dehydrogenase 4 (class II), pi polypeptide. (447 aa) |
| | STARD3 | StAR related lipid transfer domain containing 3. (480 aa) |
| | DIO3 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (130 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (628 aa) |
| | SLC16A10 | Solute carrier family 16 member 10. (611 aa) |
| | AKR1C3 | Aldo_ket_red domain-containing protein. (419 aa) |
| | LOC101098145 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa) |
| | ENSFCAP00000057338 | Uncharacterized protein. (356 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (288 aa) |
| | RDH12 | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (877 aa) |
| | BBS1 | BBS1 domain-containing protein. (602 aa) |
| | ALKBH3 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa) |
| | ENSFCAP00000060514 | Uncharacterized protein. (135 aa) |
| | CRABP2 | Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (198 aa) |
| | RDH11 | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (426 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (521 aa) |
| | AKR1E2 | Aldo-keto reductase family 1 member E2. (368 aa) |
