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EIF6 EIF6 SCARB2 SCARB2 APP APP STAT3 STAT3 SLC4A1 SLC4A1 HIF1A HIF1A PRXL2C PRXL2C MLXIPL MLXIPL EP300 EP300 FBP1 FBP1 GPD1 GPD1 NUPR1 NUPR1 P2RX7 P2RX7 ZBTB20 ZBTB20 DDIT4 DDIT4 TREX1 TREX1 HTR2A HTR2A OGT OGT INSR INSR GIT1 GIT1 PRKAG2 PRKAG2 NCOR1 NCOR1 ARL2 ARL2 HDAC4 HDAC4 ZBTB7A ZBTB7A FLCN FLCN ACTN3 ACTN3 SLC2A6 SLC2A6 ENSFCAP00000044386 ENSFCAP00000044386 PPP1R3B PPP1R3B TP53 TP53 TIGAR TIGAR SIRT6 SIRT6 CBFA2T3 CBFA2T3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SLC4A1Anion exchange protein. (911 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
PRXL2CPeroxiredoxin like 2C. (232 aa)
MLXIPLMLX interacting protein like. (857 aa)
EP300E1A binding protein p300. (2425 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
GIT1GIT ArfGAP 1. (770 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
FLCNUncharacterized protein. (579 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (933 aa)
SLC2A6Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (304 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
SIRT6Sirtuin 6. (412 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (758 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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