STRINGSTRING
DRAXIN DRAXIN PLXND1 PLXND1 BACE1 BACE1 BAX BAX NTF4 NTF4 FBXW7 FBXW7 PINK1 PINK1 GBA GBA HYOU1 HYOU1 PRKCG PRKCG DDIT3 DDIT3 RAPSN RAPSN CX3CR1 CX3CR1 TREM2 TREM2 F2R F2R HIF1A HIF1A TFAP2D TFAP2D GFRAL GFRAL XRCC2 XRCC2 NTF3 NTF3 BARHL1 BARHL1 LGMN LGMN ATF4 ATF4 KDR KDR CRLF1 CRLF1 IL6ST IL6ST NR4A2 NR4A2 ZPR1 ZPR1 GABRA5 GABRA5 MAP2K4 MAP2K4 TYRO3 TYRO3 FZD9 FZD9 NAE1 NAE1 MAP3K12 MAP3K12 BRAF BRAF MSH2 MSH2 AMBRA1 AMBRA1 TFAP2E TFAP2E AGAP2 AGAP2 ERBB3 ERBB3 SLC30A10 SLC30A10 TFAP2B TFAP2B PTPRZ1 PTPRZ1 KRAS KRAS CLCF1 CLCF1 SEMA3E SEMA3E CASP9 CASP9 PARK7 PARK7 KIF14 KIF14 THAP11 THAP11 LANCL1 LANCL1 JUN JUN CDK5 CDK5 FOXO3 FOXO3 BHLHB9 BHLHB9 MCL1 MCL1 LIG4 LIG4 FOXB1 FOXB1 TMBIM7P TMBIM7P UNC5B UNC5B ADNP ADNP OXR1 OXR1 PRKCI PRKCI AARS1 AARS1 ATM ATM TOX3 TOX3 TRIM2 TRIM2 HIPK2 HIPK2 MAG MAG ALKBH1 ALKBH1 FOXQ1 FOXQ1 PRNP PRNP MEF2C MEF2C FBXW9 FBXW9 CITED1 CITED1 TGFB2 TGFB2 GDNF GDNF KDM2B KDM2B DNAJC5 DNAJC5 AXL AXL ROCK1 ROCK1 PIK3CA PIK3CA BIRC5 BIRC5 CORO1A CORO1A ADAM8 ADAM8 HDGF HDGF VPS54 VPS54 NDNF NDNF GRIK2 GRIK2 RASA1 RASA1 EN1 EN1 EN2 EN2 PRKN PRKN FGF20 FGF20 GATA3 GATA3 NGF NGF TP53 TP53 BBC3 BBC3 NTRK1 NTRK1 NEFL NEFL PLA2G3 PLA2G3 WFS1 WFS1 GRID2 GRID2 CEBPB CEBPB CHL1 CHL1 MECP2 MECP2 BDNF BDNF SYNGAP1 SYNGAP1 BCL2L11 BCL2L11 CNTF CNTF NFATC4 NFATC4 STXBP1 STXBP1 DLX1 DLX1 TNF TNF DNAJC5B DNAJC5B SIX4 SIX4 SIGMAR1 SIGMAR1 ENSFCAP00000053370 ENSFCAP00000053370 SNCB SNCB PPARGC1A PPARGC1A NF1 NF1 ASCL1 ASCL1 NES NES ENSFCAP00000057195 ENSFCAP00000057195 BOK BOK GRN GRN VSTM2L VSTM2L ENSFCAP00000058884 ENSFCAP00000058884 IL27RA IL27RA FAIM2 FAIM2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (377 aa)
PLXND1Plexin D1. (1927 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
FBXW7F-box and WD repeat domain containing 7. (749 aa)
PINK1PTEN induced kinase 1. (581 aa)
GBAGlucosylceramidase. (536 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
TFAP2DTranscription factor AP-2 delta. (452 aa)
GFRALGDNF family receptor alpha like. (365 aa)
XRCC2X-ray repair cross complementing 2. (276 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
BARHL1BarH like homeobox 1. (327 aa)
LGMNLegumain. (433 aa)
ATF4Activating transcription factor 4. (352 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ZPR1ZPR1 zinc finger. (459 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (589 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
TFAP2ETranscription factor AP-2 epsilon. (441 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1195 aa)
ERBB3ERBB3. (1339 aa)
SLC30A10Solute carrier family 30 member 10. (483 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2140 aa)
KRASUncharacterized protein. (380 aa)
CLCF1Cardiotrophin like cytokine factor 1. (340 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa)
THAP11THAP domain containing 11. (300 aa)
LANCL1LanC like 1. (399 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
FOXO3Forkhead box O3. (672 aa)
BHLHB9Arm_2 domain-containing protein. (550 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
LIG4DNA ligase. (911 aa)
FOXB1Forkhead box B1. (325 aa)
TMBIM7PUncharacterized protein; Belongs to the BI1 family. (292 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
OXR1Oxidation resistance 1. (872 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
TOX3TOX high mobility group box family member 3. (565 aa)
TRIM2Tripartite motif containing 2. (878 aa)
HIPK2Homeodomain interacting protein kinase 2. (1222 aa)
MAGMyelin associated glycoprotein. (626 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (352 aa)
FOXQ1Forkhead box Q1. (406 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
KDM2BLysine demethylase 2B. (1264 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (655 aa)
ADAM8ADAM metallopeptidase domain 8. (872 aa)
HDGFHeparin binding growth factor. (282 aa)
VPS54VPS54 subunit of GARP complex. (977 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
RASA1RAS p21 protein activator 1. (1039 aa)
EN1Homeobox protein engrailed-like. (396 aa)
EN2Homeobox protein engrailed-like. (337 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GATA3GATA binding protein 3. (444 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
BBC3Uncharacterized protein. (193 aa)
NTRK1Tyrosine-protein kinase receptor. (770 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
CHL1Cell adhesion molecule L1 like. (1223 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
CNTFCiliary neurotrophic factor. (200 aa)
NFATC4Nuclear factor of activated T cells 4. (930 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
DLX1Distal-less homeobox 1. (255 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (211 aa)
SIX4SIX homeobox 4. (784 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (271 aa)
ENSFCAP00000053370Uncharacterized protein. (87 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (231 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
NF1Neurofibromin 1. (2856 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (246 aa)
NESNestin; Belongs to the intermediate filament family. (1733 aa)
ENSFCAP00000057195Uncharacterized protein. (34 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
GRNGranulin precursor. (596 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (284 aa)
ENSFCAP00000058884Protein kinase domain-containing protein. (375 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (335 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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