STRINGSTRING
SLC2A10 SLC2A10 KRT7 KRT7 LOC101096995 LOC101096995 KRT82 KRT82 KRT84 KRT84 KRT74 KRT74 LOC101097497 LOC101097497 KRT76 KRT76 KRT3 KRT3 KRT79 KRT79 KRT78 KRT78 ALOX12 ALOX12 PNPLA1 PNPLA1 KRT25 KRT25 KRT10 KRT10 TRPC4AP TRPC4AP ADAM9 ADAM9 ERCC2 ERCC2 ERRFI1 ERRFI1 ITGA3 ITGA3 COL1A1 COL1A1 LGR4 LGR4 TGM1 TGM1 ALX4 ALX4 ZMPSTE24 ZMPSTE24 LHX2 LHX2 PAX6 PAX6 CERS3 CERS3 CASP14 CASP14 LGR5 LGR5 FOXN1 FOXN1 EZH2 EZH2 CSTA CSTA ABCA12 ABCA12 TNFRSF19 TNFRSF19 PTCH2 PTCH2 DSP DSP LDB2 LDB2 EPHA2 EPHA2 SNAI1 SNAI1 ABCB6 ABCB6 FRAS1 FRAS1 SHARPIN SHARPIN TMEM79 TMEM79 KRT9 KRT9 CNFN CNFN TGM3 TGM3 COL3A1 COL3A1 KEL KEL IRF6 IRF6 FA2H FA2H ALOX12B ALOX12B ALOXE3 ALOXE3 ADAMTS2 ADAMTS2 PIAS4 PIAS4 GRHL3 GRHL3 ARRDC3 ARRDC3 BCR BCR IFT74 IFT74 PUM2 PUM2 DSG4 DSG4 KDF1 KDF1 APCDD1 APCDD1 COL1A2 COL1A2 FGF7 FGF7 STK4 STK4 LOC101099477 LOC101099477 SRF SRF NOTCH1 NOTCH1 CDSN CDSN KRT80 KRT80 GPR89A GPR89A UGCG UGCG WDR48 WDR48 FZD3 FZD3 ACVR1B ACVR1B LATS1 LATS1 SOS1 SOS1 KRT26 KRT26 TXNIP TXNIP STARD7 STARD7 GATA6 GATA6 WNT16 WNT16 CD109 CD109 KRT77 KRT77 ZDHHC21 ZDHHC21 IL18 IL18 TP63 TP63 INTU INTU NOM1 NOM1 CDH3 CDH3 JUP JUP SLITRK5 SLITRK5 COL5A2 COL5A2 FOXQ1 FOXQ1 SMAD4 SMAD4 LOR LOR NSUN2 NSUN2 CASP3 CASP3 SAV1 SAV1 OPN3 OPN3 TGFB2 TGFB2 LSR LSR FGF10 FGF10 ITGB4 ITGB4 CLDN1 CLDN1 FST FST TBC1D31 TBC1D31 ITGA6 ITGA6 ASH1L ASH1L PPP3CA PPP3CA NSDHL NSDHL LRP4 LRP4 SOSTDC1 SOSTDC1 FOSL2 FOSL2 WNT10A WNT10A BCL11B BCL11B PALLD PALLD SOX18 SOX18 PLEC PLEC LDB1 LDB1 POU3F1 POU3F1 CLIC4 CLIC4 HOXC13 HOXC13 EDA EDA EXT1 EXT1 NGFR NGFR MED1 MED1 CYP26B1 CYP26B1 ELOVL1 ELOVL1 LTB LTB INHBA INHBA SOX9 SOX9 ENSFCAP00000046520 ENSFCAP00000046520 ENSFCAP00000046616 ENSFCAP00000046616 ACER1 ACER1 RELA RELA GORAB GORAB OVOL1 OVOL1 LOC101087594 LOC101087594 EDAR EDAR DLX3 DLX3 YAP1 YAP1 ENSFCAP00000050360 ENSFCAP00000050360 PLA2G10 PLA2G10 SCEL SCEL TRAF3IP2 TRAF3IP2 TSG101 TSG101 SUFU SUFU LOC101096742 LOC101096742 EXPH5 EXPH5 ENSFCAP00000054558 ENSFCAP00000054558 COMP COMP KAZN KAZN NF1 NF1 ST14 ST14 ENSFCAP00000057142 ENSFCAP00000057142 CELSR1 CELSR1 HRNR HRNR PKD1 PKD1 SLC27A4 SLC27A4 DLL1 DLL1 IVL IVL ENSFCAP00000059874 ENSFCAP00000059874 SMO SMO ENSFCAP00000060169 ENSFCAP00000060169 LATS2 LATS2 MET MET SFN SFN DHCR24 DHCR24 ANXA1 ANXA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (602 aa)
KRT7Keratin 7; Belongs to the intermediate filament family. (470 aa)
LOC101096995IF rod domain-containing protein; Belongs to the intermediate filament family. (478 aa)
KRT82Keratin 82; Belongs to the intermediate filament family. (518 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (601 aa)
KRT74IF rod domain-containing protein; Belongs to the intermediate filament family. (590 aa)
LOC101097497IF rod domain-containing protein; Belongs to the intermediate filament family. (485 aa)
KRT76Keratin 76; Belongs to the intermediate filament family. (626 aa)
KRT3Keratin 3; Belongs to the intermediate filament family. (627 aa)
KRT79Keratin 79; Belongs to the intermediate filament family. (529 aa)
KRT78Keratin 78; Belongs to the intermediate filament family. (518 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
PNPLA1Patatin like phospholipase domain containing 1. (571 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (546 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (460 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
TGM1Transglutaminase 1. (820 aa)
ALX4ALX homeobox 4. (410 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
LHX2LIM homeobox 2. (406 aa)
PAX6Paired box 6. (437 aa)
CERS3Ceramide synthase 3. (387 aa)
CASP14Caspase 14; Belongs to the peptidase C14A family. (318 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
FOXN1Forkhead box N1. (646 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
CSTACystatin-A; This is an intracellular thiol proteinase inhibitor. (98 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
TNFRSF19TNF receptor superfamily member 19. (455 aa)
PTCH2Patched 2. (1207 aa)
DSPDesmoplakin. (2884 aa)
LDB2LIM domain binding 2. (373 aa)
EPHA2EPH receptor A2. (936 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ABCB6ATP binding cassette subfamily B member 6. (845 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
SHARPINSHANK associated RH domain interactor. (408 aa)
TMEM79Transmembrane protein 79. (394 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (643 aa)
CNFNCornifelin. (111 aa)
TGM3TGc domain-containing protein. (744 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
KELKell metallo-endopeptidase. (787 aa)
IRF6Interferon regulatory factor 6. (480 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1211 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
GRHL3Grainyhead like transcription factor 3. (602 aa)
ARRDC3Arrestin domain containing 3. (414 aa)
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
IFT74Intraflagellar transport 74. (600 aa)
PUM2Pumilio RNA binding family member 2. (1063 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1040 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
APCDD1APC down-regulated 1. (765 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
STK4Serine/threonine kinase 4. (487 aa)
LOC101099477IF rod domain-containing protein; Belongs to the intermediate filament family. (494 aa)
SRFSerum response factor. (512 aa)
NOTCH1Notch receptor 1. (2543 aa)
CDSNCorneodesmosin. (526 aa)
KRT80Keratin 80; Belongs to the intermediate filament family. (467 aa)
GPR89AUncharacterized protein. (490 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
WDR48WD repeat domain 48. (677 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (465 aa)
TXNIPThioredoxin interacting protein. (391 aa)
STARD7StAR related lipid transfer domain containing 7. (407 aa)
GATA6GATA binding protein 6. (646 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
CD109CD109 molecule. (1446 aa)
KRT77Keratin 77; Belongs to the intermediate filament family. (640 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (299 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
INTUInturned planar cell polarity protein. (890 aa)
NOM1Nucleolar protein with MIF4G domain 1. (919 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (831 aa)
JUPUncharacterized protein. (744 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
FOXQ1Forkhead box Q1. (406 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LORUncharacterized protein. (308 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (912 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
SAV1Salvador family WW domain containing protein 1. (395 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LSRLipolysis stimulated lipoprotein receptor. (647 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
ITGB4Integrin beta. (1828 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
FSTFollistatin. (423 aa)
TBC1D31TBC1 domain family member 31. (1066 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ASH1LASH1 like histone lysine methyltransferase. (2965 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
LRP4LDL receptor related protein 4. (1905 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
BCL11BUncharacterized protein. (895 aa)
PALLDPalladin, cytoskeletal associated protein. (1404 aa)
SOX18SRY-box transcription factor 18. (465 aa)
PLECPlectin. (4686 aa)
LDB1LIM domain binding 1. (411 aa)
POU3F1POU domain protein. (452 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
HOXC13Homeobox C13. (329 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (388 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NGFRNerve growth factor receptor. (421 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (287 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (312 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
SOX9SRY-box transcription factor 9. (511 aa)
ENSFCAP00000046520IF rod domain-containing protein; Belongs to the intermediate filament family. (148 aa)
ENSFCAP00000046616Uncharacterized protein. (1938 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
GORABGolgin, RAB6 interacting. (395 aa)
OVOL1Ovo like transcriptional repressor 1. (415 aa)
LOC101087594Uncharacterized protein. (89 aa)
EDAREctodysplasin A receptor. (447 aa)
DLX3Distal-less homeobox 3. (287 aa)
YAP1Yes associated protein 1. (498 aa)
ENSFCAP00000050360Uncharacterized protein. (97 aa)
PLA2G10Phospholipase A(2). (162 aa)
SCELSciellin. (681 aa)
TRAF3IP2TRAF3 interacting protein 2. (567 aa)
TSG101Tumor susceptibility 101. (400 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
LOC101096742IF rod domain-containing protein; Belongs to the intermediate filament family. (285 aa)
EXPH5Exophilin 5. (2004 aa)
ENSFCAP00000054558annotation not available (662 aa)
COMPCartilage oligomeric matrix protein. (804 aa)
KAZNKazrin, periplakin interacting protein. (864 aa)
NF1Neurofibromin 1. (2856 aa)
ST14Suppression of tumorigenicity 14. (861 aa)
ENSFCAP00000057142Uncharacterized protein. (773 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3085 aa)
HRNREF-hand domain-containing protein. (840 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
SLC27A4Solute carrier family 27 member 4. (691 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
IVLInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (361 aa)
ENSFCAP00000059874IF rod domain-containing protein; Belongs to the intermediate filament family. (136 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
ENSFCAP00000060169Uncharacterized protein. (103 aa)
LATS2Non-specific serine/threonine protein kinase. (1095 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
SFNStratifin; Belongs to the 14-3-3 family. (252 aa)
DHCR2424-dehydrocholesterol reductase. (571 aa)
ANXA1Annexin. (407 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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