STRINGSTRING
CCNI CCNI CDC27 CDC27 ENSFCAP00000053720 ENSFCAP00000053720 ENSFCAP00000055340 ENSFCAP00000055340 CCDC57 CCDC57 CHMP7 CHMP7 UBE2S UBE2S SIRT7 SIRT7 NEUROG1 NEUROG1 E2F6 E2F6 E2F1 E2F1 CCNA1 CCNA1 CHMP2A CHMP2A RPL24 RPL24 TRIM71 TRIM71 USP37 USP37 UBE2C UBE2C CDC23 CDC23 IQGAP3 IQGAP3 CCNE1 CCNE1 APP APP CDK16 CDK16 FBXL15 FBXL15 HINFP HINFP KDM8 KDM8 PHF8 PHF8 CTDP1 CTDP1 CDK15 CDK15 NES NES BUB1B BUB1B FBXL6 FBXL6 SKP2 SKP2 LATS2 LATS2 ENSFCAP00000060774 ENSFCAP00000060774 ENSFCAP00000061217 ENSFCAP00000061217 CDC25B CDC25B E2F3 E2F3 EZH2 EZH2 CDC25A CDC25A MTA3 MTA3 FBXL8 FBXL8 E2F4 E2F4 CCNB2 CCNB2 ANAPC2 ANAPC2 EIF4EBP1 EIF4EBP1 E2F7 E2F7 ZPR1 ZPR1 CNTD2 CNTD2 NPAT NPAT PLK1 PLK1 RCC1 RCC1 MASTL MASTL CDC16 CDC16 CDK1 CDK1 CHEK1 CHEK1 TAF10 TAF10 USP26 USP26 RBBP8 RBBP8 CDK14 CDK14 CKS2 CKS2 M3WTU8_FELCA M3WTU8_FELCA CCNJ CCNJ CCNG1 CCNG1 CCNA2 CCNA2 SOWAHB SOWAHB PIM2 PIM2 ANAPC7 ANAPC7 FBXL3 FBXL3 CCNG2 CCNG2 SPDYA SPDYA FOXM1 FOXM1 KAT14 KAT14 SPAST SPAST CDK5 CDK5 CDC25C CDC25C PPP2R2D PPP2R2D CCNE2 CCNE2 RPS6KB1 RPS6KB1 ACVR1B ACVR1B LATS1 LATS1 CCNJL CCNJL ENSFCAP00000023603 ENSFCAP00000023603 CCNY CCNY KLF11 KLF11 AFMID AFMID RB1 RB1 ANAPC1 ANAPC1 CCNO CCNO LZTS1 LZTS1 ENSFCAP00000026456 ENSFCAP00000026456 ENSFCAP00000026963 ENSFCAP00000026963 CKS1B CKS1B SMC5 SMC5 LOC101092829 LOC101092829 PPP6C PPP6C CDK2 CDK2 ITGB1 ITGB1 CDK17 CDK17 PPP3CA PPP3CA ENSFCAP00000037196 ENSFCAP00000037196 BIRC5 BIRC5 CCNB1 CCNB1 CCND3 CCND3 FBXL7 FBXL7 CDK18 CDK18 NASP NASP ENSFCAP00000041398 ENSFCAP00000041398 BACH1 BACH1 WNT10B WNT10B CCND2 CCND2 FBXL12 FBXL12 EPS8 EPS8 EIF4E EIF4E CDKN1C CDKN1C CDKN1B CDKN1B USH1C USH1C MYC MYC GPR132 GPR132 CACUL1 CACUL1 CHEK2 CHEK2 ENSA ENSA FBXL22 FBXL22 ENSFCAP00000048496 ENSFCAP00000048496 FBXL17 FBXL17 TFDP1 TFDP1 LOC101093046 LOC101093046 POLE POLE CCND1 CCND1 TAF2 TAF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNICyclin I; Belongs to the cyclin family. (380 aa)
CDC27Cell division cycle 27. (839 aa)
ENSFCAP00000053720UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (114 aa)
ENSFCAP00000055340Uncharacterized protein. (111 aa)
CCDC57Uncharacterized protein. (937 aa)
CHMP7Charged multivesicular body protein 7. (456 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (257 aa)
SIRT7Sirtuin 7. (461 aa)
NEUROG1Neurogenin 1. (243 aa)
E2F6E2F transcription factor 6. (306 aa)
E2F1E2F transcription factor 1. (436 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
RPL2460S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
TRIM71Tripartite motif containing 71. (874 aa)
USP37Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (980 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
CDC23Cell division cycle 23. (547 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1630 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
FBXL15F-box and leucine rich repeat protein 15. (378 aa)
HINFPHistone H4 transcription factor. (500 aa)
KDM8Lysine demethylase 8. (414 aa)
PHF8PHD finger protein 8. (1024 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (939 aa)
CDK15Cyclin dependent kinase 15; Belongs to the protein kinase superfamily. (435 aa)
NESNestin; Belongs to the intermediate filament family. (1733 aa)
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B. (1062 aa)
FBXL6F-box and leucine rich repeat protein 6. (537 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
LATS2Non-specific serine/threonine protein kinase. (1095 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
ENSFCAP00000061217Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (247 aa)
CDC25BCell division cycle 25B. (578 aa)
E2F3E2F transcription factor 3. (523 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
CDC25ACell division cycle 25A. (524 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
FBXL8F-box domain-containing protein. (374 aa)
E2F4E2F transcription factor 4. (406 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (1031 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
E2F7E2F transcription factor 7. (910 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (192 aa)
NPATNuclear protein, coactivator of histone transcription. (1442 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
RCC1Regulator of chromosome condensation 1. (451 aa)
MASTLMicrotubule associated serine/threonine kinase like. (882 aa)
CDC16Cell division cycle 16. (620 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
USP26Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (920 aa)
RBBP8RB binding protein 8, endonuclease. (864 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (428 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
M3WTU8_FELCAUncharacterized protein. (84 aa)
CCNJCyclin J; Belongs to the cyclin family. (383 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
SOWAHBSosondowah ankyrin repeat domain family member B. (782 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (343 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (309 aa)
FOXM1Forkhead box M1. (763 aa)
KAT14Lysine acetyltransferase 14. (782 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CDC25CCell division cycle 25C. (477 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (488 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
CCNJLCyclin J like; Belongs to the cyclin family. (388 aa)
ENSFCAP0000002360360S ribosomal protein L24. (147 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
KLF11Kruppel like factor 11. (518 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
RB1RB transcriptional corepressor 1. (930 aa)
ANAPC1Anaphase promoting complex subunit 1. (1943 aa)
CCNOCyclin O; Belongs to the cyclin family. (351 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
ENSFCAP00000026456Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (128 aa)
ENSFCAP00000026963Uncharacterized protein. (73 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
LOC101092829Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (165 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CDK17Cyclin dependent kinase 17. (523 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (600 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
FBXL7F-box and leucine rich repeat protein 7. (491 aa)
CDK18Cyclin dependent kinase 18. (553 aa)
NASPNuclear autoantigenic sperm protein. (790 aa)
ENSFCAP00000041398CYCLIN domain-containing protein; Belongs to the cyclin family. (263 aa)
BACH1BTB domain and CNC homolog 1. (748 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
FBXL12F-box and leucine rich repeat protein 12. (348 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
GPR132G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CACUL1CDK2 associated cullin domain 1; Belongs to the cullin family. (369 aa)
CHEK2Checkpoint kinase 2. (569 aa)
ENSAEndosulfine alpha; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (130 aa)
FBXL22Uncharacterized protein. (228 aa)
ENSFCAP00000048496Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
FBXL17F-box and leucine rich repeat protein 17. (699 aa)
TFDP1Transcription factor. (423 aa)
LOC101093046Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (208 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
TAF2TATA-box binding protein associated factor 2. (1251 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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