71 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLSPN	Claspin. (1327 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1551 aa)
	ENSFCAP00000061058	Reverse transcriptase domain-containing protein. (767 aa)
	ENSFCAP00000060774	Protein kinase domain-containing protein. (78 aa)
	ENSFCAP00000059078	Reverse transcriptase domain-containing protein. (240 aa)
	RINT1	RAD50 interactor 1. (794 aa)
	ENSFCAP00000057489	Uncharacterized protein. (192 aa)
	DONSON	Downstream neighbor of SON. (612 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (579 aa)
	RAD17	RAD17 checkpoint clamp loader component. (726 aa)
	ENSFCAP00000055731	Reverse transcriptase domain-containing protein. (713 aa)
	MUC1	Uncharacterized protein. (931 aa)
	PIDD1	P53-induced death domain protein 1. (940 aa)
	ENSFCAP00000054710	Reverse transcriptase domain-containing protein. (817 aa)
	SDE2	SDE2 telomere maintenance homolog. (588 aa)
	ENSFCAP00000052534	Reverse transcriptase domain-containing protein. (665 aa)
	TRIM39	Tripartite motif containing 39. (517 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (312 aa)
	MRNIP	MRN complex interacting protein. (348 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	CHEK2	Checkpoint kinase 2. (569 aa)
	SYF2	Uncharacterized protein. (246 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	C10orf90	Chromosome 10 open reading frame 90. (655 aa)
	FOXN3	Forkhead box N3. (488 aa)
	TRIM75P	Tripartite motif containing 75, pseudogene. (469 aa)
	RAD9A	RAD9 checkpoint clamp component A. (641 aa)
	GML	Glycosylphosphatidylinositol anchored molecule like. (151 aa)
	BABAM1	Uncharacterized protein. (334 aa)
	FBXO31	F-box protein 31. (643 aa)
	BRCC3	BRCA1/BRCA2-containing complex subunit 3. (316 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4108 aa)
	TIPIN	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (451 aa)
	FOXO4	Forkhead box O4. (515 aa)
	STK33	Serine/threonine kinase 33. (521 aa)
	LOC101098728	Uncharacterized protein. (289 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
	LOC101098376	Uncharacterized protein. (473 aa)
	TRIM60	Tripartite motif containing 60. (471 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa)
	TAOK3	TAO kinase 3. (914 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
	UIMC1	Ubiquitin interaction motif containing 1. (722 aa)
	RFWD3	Ring finger and WD repeat domain 3. (754 aa)
	WAC	WW domain containing adaptor with coiled-coil. (646 aa)
	ABRAXAS1	Abraxas 1, BRCA1 A complex subunit. (409 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	TICRR	TOPBP1 interacting checkpoint and replication regulator. (1884 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (612 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (370 aa)
	FANCD2	FA complementation group D2. (1450 aa)
	NOP53	NOP53 ribosome biogenesis factor. (485 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (504 aa)
	BLM	BLM RecQ like helicase. (1428 aa)
	MFSD11	Major facilitator superfamily domain containing 11. (449 aa)
	RAD9B	RAD9 checkpoint clamp component B. (344 aa)
	BABAM2	BRISC and BRCA1 A complex member 2. (386 aa)
	PML	Promyelocytic leukemia. (876 aa)
	PHKG1	Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
	XPC	XPC complex subunit, DNA damage recognition and repair factor. (944 aa)
	NEK11	NIMA related kinase 11. (654 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	ATM	ENSFCAP00000016018	ENSFCAP00000025928	Abraxas 1, BRCA1 A complex subunit.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.560
ABRAXAS1	BABAM1	ENSFCAP00000016018	ENSFCAP00000040040	Abraxas 1, BRCA1 A complex subunit.	Uncharacterized protein.	0.999
ABRAXAS1	BABAM2	ENSFCAP00000016018	ENSFCAP00000003046	Abraxas 1, BRCA1 A complex subunit.	BRISC and BRCA1 A complex member 2.	0.999
ABRAXAS1	BRCC3	ENSFCAP00000016018	ENSFCAP00000040001	Abraxas 1, BRCA1 A complex subunit.	BRCA1/BRCA2-containing complex subunit 3.	0.999
ABRAXAS1	CHEK2	ENSFCAP00000016018	ENSFCAP00000047524	Abraxas 1, BRCA1 A complex subunit.	Checkpoint kinase 2.	0.678
ABRAXAS1	ENSFCAP00000052534	ENSFCAP00000016018	ENSFCAP00000052534	Abraxas 1, BRCA1 A complex subunit.	Reverse transcriptase domain-containing protein.	0.691
ABRAXAS1	ENSFCAP00000054710	ENSFCAP00000016018	ENSFCAP00000054710	Abraxas 1, BRCA1 A complex subunit.	Reverse transcriptase domain-containing protein.	0.691
ABRAXAS1	ENSFCAP00000055731	ENSFCAP00000016018	ENSFCAP00000055731	Abraxas 1, BRCA1 A complex subunit.	Reverse transcriptase domain-containing protein.	0.691
ABRAXAS1	ENSFCAP00000059078	ENSFCAP00000016018	ENSFCAP00000059078	Abraxas 1, BRCA1 A complex subunit.	Reverse transcriptase domain-containing protein.	0.691
ABRAXAS1	ENSFCAP00000061058	ENSFCAP00000016018	ENSFCAP00000061058	Abraxas 1, BRCA1 A complex subunit.	Reverse transcriptase domain-containing protein.	0.691
ABRAXAS1	MRE11	ENSFCAP00000016018	ENSFCAP00000022057	Abraxas 1, BRCA1 A complex subunit.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.711
ABRAXAS1	NBN	ENSFCAP00000016018	ENSFCAP00000051686	Abraxas 1, BRCA1 A complex subunit.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.691
ABRAXAS1	UIMC1	ENSFCAP00000016018	ENSFCAP00000019836	Abraxas 1, BRCA1 A complex subunit.	Ubiquitin interaction motif containing 1.	0.998
ATM	ABRAXAS1	ENSFCAP00000025928	ENSFCAP00000016018	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Abraxas 1, BRCA1 A complex subunit.	0.560
ATM	BABAM1	ENSFCAP00000025928	ENSFCAP00000040040	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.619
ATM	BABAM2	ENSFCAP00000025928	ENSFCAP00000003046	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRISC and BRCA1 A complex member 2.	0.674
ATM	BLM	ENSFCAP00000025928	ENSFCAP00000005659	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BLM RecQ like helicase.	0.919
ATM	BRCC3	ENSFCAP00000025928	ENSFCAP00000040001	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1/BRCA2-containing complex subunit 3.	0.624
ATM	CCND1	ENSFCAP00000025928	ENSFCAP00000051341	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin D1; Belongs to the cyclin family.	0.495
ATM	CDK1	ENSFCAP00000025928	ENSFCAP00000013888	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.661