STRINGSTRING
MET MET ANXA1 ANXA1 CNNM3 CNNM3 CD34 CD34 SPEF1 SPEF1 SLC19A1 SLC19A1 SLC16A3 SLC16A3 PKD1 PKD1 BEST1 BEST1 MYO1C MYO1C CLASP2 CLASP2 ENSFCAP00000059689 ENSFCAP00000059689 KCNJ4 KCNJ4 CLDN19 CLDN19 BSG BSG BEST3 BEST3 PLPP3 PLPP3 SLC22A8 SLC22A8 LDLRAP1 LDLRAP1 EZR EZR NKD2 NKD2 HOMER3 HOMER3 ENSFCAP00000053834 ENSFCAP00000053834 AQP10 AQP10 RHCG RHCG AJAP1 AJAP1 CLASP1 CLASP1 GKN2 GKN2 SLC27A1 SLC27A1 CADM1 CADM1 LRRC7 LRRC7 C5AR2 C5AR2 NUMB NUMB LDLR LDLR MLC1 MLC1 SLC16A12 SLC16A12 DLG3 DLG3 VSIG1 VSIG1 SYNJ2BP SYNJ2BP CA10 CA10 PDZD11 PDZD11 AQP4 AQP4 MTTP MTTP CDH16 CDH16 LOC101095853 LOC101095853 EPB41 EPB41 KCNJ10 KCNJ10 SLC38A1 SLC38A1 ERBIN ERBIN ENSFCAP00000045292 ENSFCAP00000045292 KCNQ1 KCNQ1 OSCP1 OSCP1 CXADR CXADR PHLDB3 PHLDB3 CD300LG CD300LG TRPC4 TRPC4 S100G S100G ERBB4 ERBB4 C5AR1 C5AR1 EGFR EGFR NDRG4 NDRG4 TGFA TGFA ABCC5 ABCC5 LOC101086271 LOC101086271 LEPR LEPR PHLDB2 PHLDB2 TLR9 TLR9 SLC4A4 SLC4A4 NOD1 NOD1 LIN7C LIN7C SLCO1C1 SLCO1C1 PHLDB1 PHLDB1 SLC12A2 SLC12A2 ALPK2 ALPK2 FLOT2 FLOT2 CLDN1 CLDN1 ITGB4 ITGB4 TFRC TFRC SLC4A9 SLC4A9 ATP7B ATP7B ATP1A1 ATP1A1 ITGA1 ITGA1 SLC12A6 SLC12A6 LIN7A LIN7A SLC26A7 SLC26A7 AQP3 AQP3 CASK CASK SLC23A2 SLC23A2 AQP1 AQP1 TSHR TSHR RAB17 RAB17 SLC4A7 SLC4A7 AQP2 AQP2 HEPH HEPH SLC4A11 SLC4A11 PKD2 PKD2 CA11 CA11 SLC16A8 SLC16A8 SLC14A1 SLC14A1 ORAI1 ORAI1 MARVELD2 MARVELD2 AQP9 AQP9 SLC26A6 SLC26A6 CLDN8 CLDN8 SLC41A1 SLC41A1 LRP1 LRP1 CLDN11 CLDN11 CHRM3 CHRM3 ERBB2 ERBB2 SLC9B2 SLC9B2 SLC26A10 SLC26A10 CLDN7 CLDN7 ATP1B3 ATP1B3 PRCP PRCP AQP7 AQP7 IDE IDE SLC26A5 SLC26A5 B4GALT1 B4GALT1 SLC51B SLC51B ATP7A ATP7A FOLR1 FOLR1 SLC4A2 SLC4A2 LIN7B LIN7B SLC29A2 SLC29A2 PDGFB PDGFB CDH17 CDH17 ERBB3 ERBB3 SLC3A2 SLC3A2 MYO1A MYO1A SLC7A1 SLC7A1 MSN MSN ATP6V1B1 ATP6V1B1 FRMPD2 FRMPD2 LOC101084733 LOC101084733 SLC40A1 SLC40A1 PDPN PDPN ATP2B1 ATP2B1 SLC51A SLC51A FLOT1 FLOT1 WASF2 WASF2 KCNE3 KCNE3 SLC46A1 SLC46A1 NOD2 NOD2 BSND BSND SCRIB SCRIB SLC39A14 SLC39A14 SLC23A1 SLC23A1 SLC29A4 SLC29A4 SLC7A8 SLC7A8 CALHM1 CALHM1 CALHM3 CALHM3 TEK TEK SLC4A1 SLC4A1 SLC27A5 SLC27A5 UMOD UMOD SLC4A10 SLC4A10 ITGA3 ITGA3 HPGD HPGD ABCC6 ABCC6 HFE HFE STX2 STX2 ADCY8 ADCY8 DSTYK DSTYK AQP5 AQP5 CD81 CD81 SLC22A7 SLC22A7 ABCC10 ABCC10 CLRN1 CLRN1 ANXA13 ANXA13 STK39 STK39 SLC2A9 SLC2A9 SLC43A3 SLC43A3 SLC13A3 SLC13A3 RHBG RHBG SLC39A8 SLC39A8 SLC39A5 SLC39A5 ITGA2 ITGA2 LPO LPO ABCC3 ABCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
ANXA1Annexin. (407 aa)
CNNM3Cyclin and CBS domain divalent metal cation transport mediator 4. (796 aa)
CD34CD34 molecule. (406 aa)
SPEF1Sperm flagellar 1. (343 aa)
SLC19A1Solute carrier family 19 member 1. (522 aa)
SLC16A3Solute carrier family 16 member 3. (542 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (654 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1074 aa)
CLASP2Cytoplasmic linker associated protein 2. (1538 aa)
ENSFCAP00000059689Uncharacterized protein. (377 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (457 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (263 aa)
BSGBasigin. (356 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (680 aa)
PLPP3acidPPc domain-containing protein. (324 aa)
SLC22A8Solute carrier family 22 member 8. (527 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (327 aa)
EZREzrin. (639 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (488 aa)
HOMER3Uncharacterized protein. (419 aa)
ENSFCAP00000053834Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (193 aa)
AQP10Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (341 aa)
RHCGRh family C glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (470 aa)
AJAP1Adherens junctions associated protein 1. (431 aa)
CLASP1Cytoplasmic linker associated protein 1. (1597 aa)
GKN2Gastrokine 2. (236 aa)
SLC27A1Solute carrier family 27 member 1. (796 aa)
CADM1Cell adhesion molecule 1. (593 aa)
LRRC7Leucine rich repeat containing 7. (1575 aa)
C5AR2Complement component 5a receptor 2. (332 aa)
NUMBNUMB endocytic adaptor protein. (653 aa)
LDLRLow density lipoprotein receptor. (866 aa)
MLC1Modulator of VRAC current 1. (373 aa)
SLC16A12Solute carrier family 16 member 12. (486 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
VSIG1V-set and immunoglobulin domain containing 1. (423 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
CA10Carbonic anhydrase 10; Belongs to the alpha-carbonic anhydrase family. (383 aa)
PDZD11PDZ domain containing 11. (179 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
MTTPMicrosomal triglyceride transfer protein. (894 aa)
CDH16Cadherin 16. (829 aa)
LOC101095853Folate_rec domain-containing protein. (256 aa)
EPB41Erythrocyte membrane protein band 4.1. (874 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (563 aa)
SLC38A1Solute carrier family 38 member 1. (499 aa)
ERBINErbb2 interacting protein. (1461 aa)
ENSFCAP00000045292CH_2 domain-containing protein. (564 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (692 aa)
OSCP1Organic solute carrier partner 1. (389 aa)
CXADRUncharacterized protein. (352 aa)
PHLDB3Pleckstrin homology like domain family B member 3. (716 aa)
CD300LGCD300 molecule like family member g. (333 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (985 aa)
S100GProtein S100; Belongs to the S-100 family. (79 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NDRG4NDRG family member 4. (424 aa)
TGFATransforming growth factor alpha. (192 aa)
ABCC5ATP binding cassette subfamily C member 5. (1437 aa)
LOC101086271Uncharacterized protein. (509 aa)
LEPRLeptin receptor. (1166 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1247 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
SLC4A4Anion exchange protein. (1118 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
SLCO1C1Solute carrier organic anion transporter family member. (712 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1547 aa)
SLC12A2Solute carrier family 12 member 2. (1204 aa)
ALPK2Alpha kinase 2. (2089 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (553 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ITGB4Integrin beta. (1828 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
SLC4A9Anion exchange protein. (956 aa)
ATP7BATPase copper transporting beta. (1470 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1038 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
SLC12A6Solute carrier family 12 member 6. (1151 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
SLC26A7Anion exchange transporter. (656 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (935 aa)
SLC23A2Solute carrier family 23 member 2. (691 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (310 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (770 aa)
RAB17RAB17, member RAS oncogene family. (213 aa)
SLC4A7Anion exchange protein. (1258 aa)
AQP2Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
HEPHHephaestin; Belongs to the multicopper oxidase family. (1180 aa)
SLC4A11Solute carrier family 4 member 11. (883 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
CA11Carbonic anhydrase 11; Belongs to the alpha-carbonic anhydrase family. (328 aa)
SLC16A8Solute carrier family 16 member 8. (500 aa)
SLC14A1Solute carrier family 14 member 1. (689 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
MARVELD2MARVEL domain containing 2. (559 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
SLC26A6Solute carrier family 26 member 6. (756 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
SLC41A1Solute carrier family 41 member 1. (514 aa)
LRP1LDL receptor related protein 1. (4561 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (619 aa)
ERBB2Receptor protein-tyrosine kinase. (1308 aa)
SLC9B2Solute carrier family 9 member B2. (547 aa)
SLC26A10Solute carrier family 26 member 10. (686 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PRCPProlylcarboxypeptidase. (548 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (350 aa)
IDEInsulin degrading enzyme. (1219 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (727 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (400 aa)
SLC51BSolute carrier family 51 beta subunit. (133 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
FOLR1Folate receptor alpha. (302 aa)
SLC4A2Anion exchange protein. (1237 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
CDH17Cadherin 17. (832 aa)
ERBB3ERBB3. (1339 aa)
SLC3A2Solute carrier family 3 member 2. (170 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1042 aa)
SLC7A1Solute carrier family 7 member 1. (803 aa)
MSNMoesin. (577 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
FRMPD2FERM and PDZ domain containing 2. (1303 aa)
LOC101084733Folate_rec domain-containing protein. (248 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (576 aa)
PDPNPodoplanin. (163 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
SLC51ASolute carrier family 51 alpha subunit. (364 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
WASF2WASP family member 2. (498 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
BSNDBarttin CLCNK type accessory beta subunit. (318 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
SLC39A14Solute carrier family 39 member 14. (491 aa)
SLC23A1Solute carrier family 23 member 1. (601 aa)
SLC29A4Solute carrier family 29 member 4. (633 aa)
SLC7A8Solute carrier family 7 member 8. (534 aa)
CALHM1Calcium homeostasis modulator 1. (345 aa)
CALHM3Calcium homeostasis modulator 3. (347 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
SLC4A1Anion exchange protein. (911 aa)
SLC27A5Solute carrier family 27 member 5. (687 aa)
UMODUromodulin. (642 aa)
SLC4A10Anion exchange protein. (1118 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
ABCC6ATP binding cassette subfamily C member 6. (1504 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (929 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
CD81Tetraspanin. (236 aa)
SLC22A7Solute carrier family 22 member 7. (552 aa)
ABCC10ATP binding cassette subfamily C member 10. (1491 aa)
CLRN1Uncharacterized protein. (232 aa)
ANXA13Annexin. (357 aa)
STK39Serine/threonine kinase 39. (543 aa)
SLC2A9Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (741 aa)
SLC43A3Solute carrier family 43 member 3. (476 aa)
SLC13A3Solute carrier family 13 member 3. (515 aa)
RHBGRh family B glycoprotein (gene/pseudogene); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (458 aa)
SLC39A8Solute carrier family 39 member 8. (461 aa)
SLC39A5Solute carrier family 39 member 5. (543 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1177 aa)
LPOLactoperoxidase. (711 aa)
ABCC3ATP binding cassette subfamily C member 3. (1421 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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