32 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	CLEC4G	C-type lectin domain family 4 member G. (317 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
	TMEM131L	Transmembrane 131 like. (1609 aa)
	IFNB1	Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
	FOXJ1	Forkhead box J1. (417 aa)
	BCL6	BCL6 transcription repressor. (745 aa)
	LAG3	Lymphocyte activating 3. (513 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (311 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
	ZBTB7B	Uncharacterized protein. (540 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LOC101082108	Ig-like domain-containing protein. (386 aa)
	HLX	H2.0 like homeobox. (569 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	FGL2	Fibrinogen like 2. (440 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
	ANXA1	Annexin. (407 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SOCS1	Suppressor of cytokine signaling 1. (203 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1133 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1132 aa)
	CBFB	Uncharacterized protein. (187 aa)
	FOXP3	Forkhead box P3. (501 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (416 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (268 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CTLA4	ENSFCAP00000006325	ENSFCAP00000041200	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.707
BCL6	FOXP3	ENSFCAP00000006325	ENSFCAP00000043740	BCL6 transcription repressor.	Forkhead box P3.	0.847
BCL6	IL2	ENSFCAP00000006325	ENSFCAP00000012696	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.534
BCL6	IL4	ENSFCAP00000006325	ENSFCAP00000002290	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.829
BCL6	TBX21	ENSFCAP00000006325	ENSFCAP00000009847	BCL6 transcription repressor.	T-box transcription factor 21.	0.620
BMP4	CBFB	ENSFCAP00000051185	ENSFCAP00000045631	Bone morphogenetic protein 4.	Uncharacterized protein.	0.422
BMP4	IHH	ENSFCAP00000051185	ENSFCAP00000017498	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.585
BMP4	SHH	ENSFCAP00000051185	ENSFCAP00000061011	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.783
BMP4	SMAD7	ENSFCAP00000051185	ENSFCAP00000042878	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.719
CBFB	BMP4	ENSFCAP00000045631	ENSFCAP00000051185	Uncharacterized protein.	Bone morphogenetic protein 4.	0.422
CBFB	FOXP3	ENSFCAP00000045631	ENSFCAP00000043740	Uncharacterized protein.	Forkhead box P3.	0.607
CLEC4G	LAG3	ENSFCAP00000001486	ENSFCAP00000006393	C-type lectin domain family 4 member G.	Lymphocyte activating 3.	0.493
CTLA4	BCL6	ENSFCAP00000041200	ENSFCAP00000006325	Cytotoxic T-lymphocyte associated protein 4.	BCL6 transcription repressor.	0.707
CTLA4	FGL2	ENSFCAP00000041200	ENSFCAP00000039612	Cytotoxic T-lymphocyte associated protein 4.	Fibrinogen like 2.	0.621
CTLA4	FOXP3	ENSFCAP00000041200	ENSFCAP00000043740	Cytotoxic T-lymphocyte associated protein 4.	Forkhead box P3.	0.863
CTLA4	IL2	ENSFCAP00000041200	ENSFCAP00000012696	Cytotoxic T-lymphocyte associated protein 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.774
CTLA4	IL4	ENSFCAP00000041200	ENSFCAP00000002290	Cytotoxic T-lymphocyte associated protein 4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.669
CTLA4	LAG3	ENSFCAP00000041200	ENSFCAP00000006393	Cytotoxic T-lymphocyte associated protein 4.	Lymphocyte activating 3.	0.870
CTLA4	TBX21	ENSFCAP00000041200	ENSFCAP00000009847	Cytotoxic T-lymphocyte associated protein 4.	T-box transcription factor 21.	0.445
FGL2	CTLA4	ENSFCAP00000039612	ENSFCAP00000041200	Fibrinogen like 2.	Cytotoxic T-lymphocyte associated protein 4.	0.621