59 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	STAT5B	Signal transducer and activator of transcription. (786 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
	SOX13	SRY-box 13. (619 aa)
	EGR3	Early growth response 3. (392 aa)
	SASH3	SAM and SH3 domain containing 3. (379 aa)
	BCL6	BCL6 transcription repressor. (745 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1066 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	IL23A	Interleukin 23 subunit alpha. (196 aa)
	RHOH	Ras homolog family member H. (191 aa)
	VSIR	V-set immunoregulatory receptor. (311 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	MALT1	MALT1 paracaspase. (848 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	ZBTB7B	Uncharacterized protein. (540 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (679 aa)
	NLRP3	NLR family pyrin domain containing 3. (1038 aa)
	LOC101082108	Ig-like domain-containing protein. (386 aa)
	FOXO3	Forkhead box O3. (672 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
	TNFSF9	TNF superfamily member 9; Belongs to the tumor necrosis factor family. (250 aa)
	CD83	CD83 molecule. (391 aa)
	HLX	H2.0 like homeobox. (569 aa)
	IL7	Interleukin 7. (158 aa)
	ADAM8	ADAM metallopeptidase domain 8. (872 aa)
	SOX12	Transcription factor SOX. (314 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
	XBP1	X-box binding protein 1. (383 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	NCKAP1L	NCK associated protein 1 like. (1179 aa)
	FOXP3	Forkhead box P3. (501 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CBFB	Uncharacterized protein. (187 aa)
	SHB	SH2 domain-containing protein. (508 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	SOCS1	Suppressor of cytokine signaling 1. (203 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (803 aa)
	LOC101081130	AIG1-type G domain-containing protein. (309 aa)
	LEF1	Lymphoid enhancer binding factor 1. (415 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (390 aa)
	NFKBIZ	NFKB inhibitor zeta. (956 aa)
	PRKCZ	Protein kinase C zeta. (649 aa)
	RASGRP1	RAS guanyl releasing protein 1. (877 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1299 aa)
	ADA	Adenosine deaminase. (431 aa)
	ANXA1	Annexin. (407 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
	CCL19	C-C motif chemokine. (115 aa)
	CD27	CD27 molecule. (296 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	IL2RG	ENSFCAP00000057865	ENSFCAP00000049536	Adenosine deaminase.	Fibronectin type-III domain-containing protein.	0.402
BCL6	CD27	ENSFCAP00000006325	ENSFCAP00000061814	BCL6 transcription repressor.	CD27 molecule.	0.593
BCL6	FOXP3	ENSFCAP00000006325	ENSFCAP00000043740	BCL6 transcription repressor.	Forkhead box P3.	0.847
BCL6	GATA3	ENSFCAP00000006325	ENSFCAP00000044199	BCL6 transcription repressor.	GATA binding protein 3.	0.609
BCL6	IFNG	ENSFCAP00000006325	ENSFCAP00000008355	BCL6 transcription repressor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.610
BCL6	IL4	ENSFCAP00000006325	ENSFCAP00000002290	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.829
BCL6	XBP1	ENSFCAP00000006325	ENSFCAP00000041558	BCL6 transcription repressor.	X-box binding protein 1.	0.753
CBFB	FOXP3	ENSFCAP00000045631	ENSFCAP00000043740	Uncharacterized protein.	Forkhead box P3.	0.607
CBFB	GATA3	ENSFCAP00000045631	ENSFCAP00000044199	Uncharacterized protein.	GATA binding protein 3.	0.579
CCL19	IFNG	ENSFCAP00000061657	ENSFCAP00000008355	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.600
CCL19	IL4	ENSFCAP00000061657	ENSFCAP00000002290	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.533
CCL19	IL7	ENSFCAP00000061657	ENSFCAP00000032766	C-C motif chemokine.	Interleukin 7.	0.586
CD27	BCL6	ENSFCAP00000061814	ENSFCAP00000006325	CD27 molecule.	BCL6 transcription repressor.	0.593
CD27	CD83	ENSFCAP00000061814	ENSFCAP00000031426	CD27 molecule.	CD83 molecule.	0.480
CD27	FOXP3	ENSFCAP00000061814	ENSFCAP00000043740	CD27 molecule.	Forkhead box P3.	0.656
CD27	IFNG	ENSFCAP00000061814	ENSFCAP00000008355	CD27 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.734
CD27	IL4	ENSFCAP00000061814	ENSFCAP00000002290	CD27 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.589
CD27	IL7	ENSFCAP00000061814	ENSFCAP00000032766	CD27 molecule.	Interleukin 7.	0.521
CD27	SYK	ENSFCAP00000061814	ENSFCAP00000013189	CD27 molecule.	Spleen associated tyrosine kinase.	0.417
CD27	TNFSF9	ENSFCAP00000061814	ENSFCAP00000031348	CD27 molecule.	TNF superfamily member 9; Belongs to the tumor necrosis factor family.	0.596