Your Input: | |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1127 aa) |
| | EEF1AKNMT | EEF1A lysine and N-terminal methyltransferase. (699 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | HEXIM2 | HEXIM P-TEFb complex subunit 2. (292 aa) |
| | FBXO5 | F-box protein 5. (451 aa) |
| | MDM1 | Mdm1 nuclear protein. (729 aa) |
| | CTDSP2 | CTD small phosphatase 2. (271 aa) |
| | NANOS2 | Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | TRIM60 | Tripartite motif containing 60. (471 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa) |
| | HORMAD1 | HORMA domain containing 1. (413 aa) |
| | ZWILCH | Zwilch kinetochore protein. (630 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1551 aa) |
| | ENSFCAP00000061110 | TGF_BETA_2 domain-containing protein. (362 aa) |
| | ENSFCAP00000061058 | Reverse transcriptase domain-containing protein. (767 aa) |
| | RNF167 | Ring finger protein 167. (366 aa) |
| | SKA2 | Tripartite motif containing 37. (987 aa) |
| | ENSFCAP00000060774 | Protein kinase domain-containing protein. (78 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1095 aa) |
| | TMPRSS5 | Zw10 kinetochore protein. (848 aa) |
| | CCDC84 | Coiled-coil domain containing 84. (437 aa) |
| | NPR2 | Guanylate cyclase. (1057 aa) |
| | ENSFCAP00000059078 | Reverse transcriptase domain-containing protein. (240 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1817 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1485 aa) |
| | GAS1 | Growth arrest specific 1. (369 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (804 aa) |
| | RINT1 | RAD50 interactor 1. (794 aa) |
| | ENSFCAP00000057489 | Uncharacterized protein. (192 aa) |
| | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B. (1062 aa) |
| | DONSON | Downstream neighbor of SON. (612 aa) |
| | ENSFCAP00000056200 | MOEP19 domain-containing protein. (399 aa) |
| | AVEN | Apoptosis and caspase activation inhibitor. (356 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (579 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (726 aa) |
| | ENSFCAP00000055731 | Reverse transcriptase domain-containing protein. (713 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa) |
| | PTTG1 | Uncharacterized protein. (213 aa) |
| | MUC1 | Uncharacterized protein. (931 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (641 aa) |
| | NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa) |
| | PIDD1 | P53-induced death domain protein 1. (940 aa) |
| | ENSFCAP00000054710 | Reverse transcriptase domain-containing protein. (817 aa) |
| | MTBP | MDM2 binding protein. (911 aa) |
| | ENSFCAP00000053448 | Uncharacterized protein. (182 aa) |
| | NKX3-1 | NK3 homeobox 1. (231 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (588 aa) |
| | ENSFCAP00000052534 | Reverse transcriptase domain-containing protein. (665 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (678 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (408 aa) |
| | INCA1 | Inhibitor of CDK, cyclin A1 interacting protein 1. (256 aa) |
| | CHFR | Checkpoint with forkhead and ring finger domains. (833 aa) |
| | TRIM39 | Tripartite motif containing 39. (517 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (448 aa) |
| | LOC111559734 | Bone morphogenetic protein 7. (426 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | MRNIP | MRN complex interacting protein. (348 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | MEN1 | Menin 1. (749 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa) |
| | MYOCD | Myocardin. (962 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (1012 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (415 aa) |
| | IZUMO4 | IZUMO family member 4. (229 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (840 aa) |
| | ATF5 | Activating transcription factor 5. (280 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | CHEK2 | Checkpoint kinase 2. (569 aa) |
| | CDK5RAP2 | CDK5 regulatory subunit associated protein 2. (1856 aa) |
| | GPR132 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | MAP3K20 | Uncharacterized protein. (800 aa) |
| | SYF2 | Uncharacterized protein. (246 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (705 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa) |
| | HECA | Hdc homolog, cell cycle regulator. (584 aa) |
| | TOM1L1 | Target of myb1 like 1 membrane trafficking protein. (521 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (264 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | C10orf90 | Chromosome 10 open reading frame 90. (655 aa) |
| | CDK2AP2 | Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (127 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (741 aa) |
| | FOXN3 | Forkhead box N3. (488 aa) |
| | C10orf99 | Chromosome 10 open reading frame 99. (81 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2498 aa) |
| | BRINP2 | BMP/retinoic acid inducible neural specific 2. (784 aa) |
| | TRIM75P | Tripartite motif containing 75, pseudogene. (469 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (641 aa) |
| | TPRA1 | Transmembrane protein adipocyte associated 1. (439 aa) |
| | GML | Glycosylphosphatidylinositol anchored molecule like. (151 aa) |
| | TFAP4 | Transcription factor AP-4. (337 aa) |
| | BTG1 | BTG anti-proliferation factor 1. (171 aa) |
| | BABAM1 | Uncharacterized protein. (334 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (162 aa) |
| | FBXO31 | F-box protein 31. (643 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | BRINP1 | BMP/retinoic acid inducible neural specific 1. (761 aa) |
| | ANGEL2 | Angel homolog 2. (544 aa) |
| | ZNF207 | Zinc finger protein 207. (538 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | APC | APC regulator of WNT signaling pathway. (2874 aa) |
| | CCP110 | Centriolar coiled-coil protein 110. (1009 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1139 aa) |
| | ENSFCAP00000038408 | Uncharacterized protein. (249 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | TOM1L2 | Target of myb1 like 2 membrane trafficking protein. (551 aa) |
| | JADE1 | Jade family PHD finger 1. (1001 aa) |
| | MIIP | Migration and invasion inhibitory protein. (460 aa) |
| | NLE1 | Notchless homolog 1. (485 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (598 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | NME6 | Nucleoside diphosphate kinase. (193 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1637 aa) |
| | HINFP | Histone H4 transcription factor. (500 aa) |
| | NEK11 | NIMA related kinase 11. (654 aa) |
| | IK | IK cytokine. (555 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (944 aa) |
| | FBXO43 | F-box protein 43. (700 aa) |
| | CCNF | Cyclin F; Belongs to the cyclin family. (848 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa) |
| | CTDSPL | CTD small phosphatase like. (283 aa) |
| | CTDSP1 | CTD small phosphatase 1. (261 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (851 aa) |
| | INTS3 | Integrator complex subunit 3. (1012 aa) |
| | TP53I13 | Tumor protein p53 inducible protein 13. (394 aa) |
| | PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa) |
| | PML | Promyelocytic leukemia. (876 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | CTNNB1 | Catenin beta 1. (783 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (678 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (344 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa) |
| | HPGD | 15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | BTG4 | BTG anti-proliferation factor 4. (224 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (916 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | HEXIM1 | HEXIM P-TEFb complex subunit 1. (359 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (266 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | BLM | BLM RecQ like helicase. (1428 aa) |
| | DMRT1 | Doublesex and mab-3 related transcription factor 1. (378 aa) |
| | RBM14 | RNA binding motif protein 14. (669 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (955 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa) |
| | INTS7 | Integrator complex subunit 7. (962 aa) |
| | KNTC1 | Kinetochore associated 1. (2207 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | GMNC | Geminin coiled-coil domain containing. (336 aa) |
| | NACC2 | NACC family member 2. (581 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (504 aa) |
| | SUSD2 | Sushi domain containing 2. (823 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | CDC5L | Cell division cycle 5 like. (802 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | FBXO7 | F-box protein 7. (444 aa) |
| | TENT5B | Terminal nucleotidyltransferase 5B. (427 aa) |
| | E2F8 | E2F transcription factor 8. (864 aa) |
| | E2F7 | E2F transcription factor 7. (910 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | NOP53 | NOP53 ribosome biogenesis factor. (485 aa) |
| | ENSFCAP00000037485 | Uncharacterized protein. (183 aa) |
| | PTPN3 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (935 aa) |
| | FANCD2 | FA complementation group D2. (1450 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (370 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | TIMELESS | Timeless circadian regulator. (1211 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1482 aa) |
| | NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (589 aa) |
| | TMEM67 | Transmembrane protein 67. (994 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (604 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (612 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1884 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1086 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | DCUN1D3 | Defective in cullin neddylation 1 domain containing 3. (304 aa) |
| | CDK5RAP1 | CDK5 regulatory subunit associated protein 1. (583 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (509 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (960 aa) |
| | NEK2 | NIMA related kinase 2. (444 aa) |
| | LRRC1 | Leucine rich repeat containing 1. (524 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (646 aa) |
| | GMNN | Geminin DNA replication inhibitor. (210 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa) |
| | WAPL | WAPL cohesin release factor. (1196 aa) |
| | KANK2 | KN motif and ankyrin repeat domains 2. (857 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4108 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1143 aa) |
| | TIPRL | TOR signaling pathway regulator. (313 aa) |
| | LIF | LIF interleukin 6 family cytokine. (204 aa) |
| | ZFYVE19 | Zinc finger FYVE-type containing 19. (400 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa) |
| | NUDT6 | Nudix hydrolase 6; Belongs to the Nudix hydrolase family. (316 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | THAP5 | THAP domain containing 5. (393 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (451 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | NSUN2 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (912 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (221 aa) |
| | FOXO4 | Forkhead box O4. (515 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | BMP2 | Bone morphogenetic protein 2. (395 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1092 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | STK33 | Serine/threonine kinase 33. (521 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (768 aa) |
| | LOC101098728 | Uncharacterized protein. (289 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | CLSPN | Claspin. (1327 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (970 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1484 aa) |
| | LOC101098376 | Uncharacterized protein. (473 aa) |
| | BRINP3 | BMP/retinoic acid inducible neural specific 3. (766 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (237 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | BTG3 | BTG anti-proliferation factor 3. (267 aa) |
| | FHL1 | Four and a half LIM domains 1. (366 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa) |
| | GPNMB | Glycoprotein nmb. (568 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | ATRX | ATRX chromatin remodeler. (2486 aa) |
| | HHEX | Hematopoietically expressed homeobox. (270 aa) |
| | CRLF3 | Cytokine receptor like factor 3. (498 aa) |
| | TTK | TTK protein kinase. (856 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (754 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (722 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1653 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | NUPR2 | Nuclear protein 2, transcriptional regulator. (103 aa) |
| | TRIM35 | Tripartite motif containing 35. (493 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | TAOK3 | TAO kinase 3. (914 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | NABP1 | Nucleic acid binding protein 1. (219 aa) |
| | HASPIN | Histone H3 associated protein kinase. (782 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
