STRINGSTRING
CDK5R1 CDK5R1 UBXN2B UBXN2B CDC25B CDC25B EIF4EBP3 EIF4EBP3 DDX39A DDX39A CSPP1 CSPP1 SMPD3 SMPD3 ANXA1 ANXA1 ENSFCAP00000060774 ENSFCAP00000060774 MAPK15 MAPK15 NUMA1 NUMA1 CCPG1 CCPG1 AIF1 AIF1 SVIL SVIL FAM178B FAM178B RAB11A RAB11A DRD3 DRD3 ROCK2 ROCK2 PSRC1 PSRC1 PKD1 PKD1 NSMCE2 NSMCE2 LOC101088142 LOC101088142 CEP120 CEP120 CENPV CENPV ZBED6 ZBED6 LSM10 LSM10 SMOC2 SMOC2 ASCL1 ASCL1 CB2H6orf89 CB2H6orf89 ENSFCAP00000056502 ENSFCAP00000056502 NEUROG1 NEUROG1 SIRT2 SIRT2 CDC14A CDC14A CCNT2 CCNT2 LOC102901812 LOC102901812 CCDC57 CCDC57 STRA8 STRA8 STAT5A STAT5A CDT1 CDT1 LSM11 LSM11 HNRNPU HNRNPU ENSFCAP00000054808 ENSFCAP00000054808 BHMG1 BHMG1 MTBP MTBP NSFL1C NSFL1C ENSFCAP00000053720 ENSFCAP00000053720 DYNC1H1 DYNC1H1 NKX3-1 NKX3-1 CDC27 CDC27 AURKB AURKB PAF1 PAF1 GPSM2 GPSM2 HOXA13 HOXA13 CCND1 CCND1 HES1 HES1 PRDM7 PRDM7 PCID2 PCID2 FOXG1 FOXG1 BCL2L11 BCL2L11 MNAT1 MNAT1 MECP2 MECP2 TFDP1 TFDP1 TBX3 TBX3 DUSP3 DUSP3 MSX1 MSX1 OVOL1 OVOL1 ENSFCAP00000048496 ENSFCAP00000048496 DBF4B DBF4B MBLAC1 MBLAC1 CCNT1 CCNT1 PLK4 PLK4 STXBP4 STXBP4 NUDT16 NUDT16 SHB SHB MAP3K20 MAP3K20 SFPQ SFPQ POLDIP2 POLDIP2 MED1 MED1 ENSFCAP00000044386 ENSFCAP00000044386 STOX1 STOX1 USP2 USP2 NPM2 NPM2 CDK5R2 CDK5R2 DTL DTL PPP1R35 PPP1R35 CXCR5 CXCR5 CUL3 CUL3 CRNN CRNN EIF4E EIF4E CCND2 CCND2 TPR TPR ZBED6CL ZBED6CL SH2B1 SH2B1 WNT10B WNT10B MAP10 MAP10 RPTOR RPTOR CCNK CCNK EGFR EGFR RAD51B RAD51B TGFA TGFA KAT5 KAT5 EPGN EPGN TRIM21 TRIM21 CCND3 CCND3 ECT2 ECT2 BIRC5 BIRC5 ENSFCAP00000037196 ENSFCAP00000037196 PRKCE PRKCE MARK4 MARK4 SMC2 SMC2 BTC BTC HSF1 HSF1 FGF10 FGF10 MAD2L1 MAD2L1 MAPRE3 MAPRE3 GIPC2 GIPC2 CDC14B CDC14B ENSFCAP00000030965 ENSFCAP00000030965 INSR INSR PTPN11 PTPN11 SMC4 SMC4 ENSFCAP00000028934 ENSFCAP00000028934 DDX39B DDX39B FBXO42 FBXO42 SMC5 SMC5 CKS1B CKS1B RANBP1 RANBP1 ENSFCAP00000026963 ENSFCAP00000026963 CUL4B CUL4B ENSFCAP00000026456 ENSFCAP00000026456 PKD2 PKD2 DYRK3 DYRK3 MDM2 MDM2 ZNF112 ZNF112 LRP5 LRP5 RB1 RB1 CDC42-2 CDC42-2 AFMID AFMID CCNY CCNY RHNO1 RHNO1 CDCA5 CDCA5 SLF1 SLF1 THOC1 THOC1 CDC6 CDC6 CDC7 CDC7 CEP295 CEP295 CITED2 CITED2 ASNS ASNS RPS6KB1 RPS6KB1 SASS6 SASS6 RRM2B RRM2B PSMD10 PSMD10 PHB2 PHB2 RAD51C RAD51C XRCC3 XRCC3 CDC25C CDC25C NCAPG NCAPG FOXA1 FOXA1 DBF4 DBF4 RAD23A RAD23A SPDYA SPDYA ANKRD31 ANKRD31 PKN2 PKN2 ANAPC7 ANAPC7 KIF14 KIF14 BRCA2 BRCA2 DDX3X DDX3X VPS4B VPS4B EREG EREG LOC101084379 LOC101084379 TRIM32 TRIM32 PAGR1 PAGR1 CDK4 CDK4 RHOA RHOA CCNYL1 CCNYL1 M3WTU8_FELCA M3WTU8_FELCA ATRX ATRX CKS2 CKS2 M3WSW9_FELCA M3WSW9_FELCA SLF2 SLF2 SPDYC SPDYC PROX1 PROX1 NDC80 NDC80 MEIOC MEIOC PLRG1 PLRG1 PDGFB PDGFB KLHL18 KLHL18 RAB11B RAB11B CHEK1 CHEK1 CDK1 CDK1 EDN1 EDN1 INO80 INO80 CDC16 CDC16 PBK PBK CD28 CD28 CUL4A CUL4A ANKRD17 ANKRD17 MACROH2A1 MACROH2A1 FEN1 FEN1 GEN1 GEN1 IL10 IL10 GIPC1 GIPC1 RAD21 RAD21 ADAMTS1 ADAMTS1 BECN1 BECN1 NCAPH2 NCAPH2 PIWIL2 PIWIL2 NUSAP1 NUSAP1 ANAPC5 ANAPC5 NUPR1 NUPR1 STIL STIL PRKCA PRKCA ZPR1 ZPR1 SIN3A SIN3A MEPCE MEPCE E2F7 E2F7 E2F8 E2F8 EIF4EBP1 EIF4EBP1 RCC2 RCC2 MAD2L1BP MAD2L1BP SOX15 SOX15 RACGAP1 RACGAP1 NCAPG2 NCAPG2 TBX2 TBX2 MTA3 MTA3 CDC25A CDC25A EZH2 EZH2 LFNG LFNG SPAG5 SPAG5 IL1A IL1A DYNC1LI1 DYNC1LI1 LGMN LGMN CPSF3 CPSF3 HSPA2 HSPA2 RRM1 RRM1 NRM NRM PPP1R10 PPP1R10 GIPC3 GIPC3 ATAD5 ATAD5 OOEP OOEP DMRT1 DMRT1 SLC6A4 SLC6A4 IL1B IL1B TGM1 TGM1 SPHK1 SPHK1 MAD1L1 MAD1L1 ABL1 ABL1 CENPJ CENPJ CDC42 CDC42 KAT2B KAT2B THOC5 THOC5 RRM2 RRM2 KMT2E KMT2E NR2E1 NR2E1 STAT5B STAT5B GLI1 GLI1 NUP62CL NUP62CL UBE2C UBE2C LOC101099765 LOC101099765 CDC23 CDC23 NANOG NANOG APP APP CIT CIT CDC73 CDC73 LRP6 LRP6
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
UBXN2BUBX domain protein 2B. (440 aa)
CDC25BCell division cycle 25B. (578 aa)
EIF4EBP3ANK_REP_REGION domain-containing protein. (2635 aa)
DDX39ADExD-box helicase 39A. (518 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1226 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (674 aa)
ANXA1Annexin. (407 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
MAPK15Mitogen-activated protein kinase. (550 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2135 aa)
CCPG1Cell cycle progression 1. (840 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
SVILSupervillin. (2361 aa)
FAM178BUncharacterized protein. (169 aa)
RAB11ARAB11A, member RAS oncogene family. (217 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
PSRC1Proline and serine rich coiled-coil 1. (407 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (306 aa)
LOC101088142GFA domain-containing protein. (262 aa)
CEP120Centrosomal protein 120. (987 aa)
CENPVGFA domain-containing protein. (297 aa)
ZBED6Zinc finger BED-type containing 6. (980 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
SMOC2SPARC related modular calcium binding 2. (570 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (246 aa)
CB2H6orf89Chromosome B2 C6orf89 homolog. (422 aa)
ENSFCAP00000056502Uncharacterized protein. (421 aa)
NEUROG1Neurogenin 1. (243 aa)
SIRT2Sirtuin 2. (497 aa)
CDC14ACell division cycle 14A. (598 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (742 aa)
LOC102901812Uncharacterized protein. (283 aa)
CCDC57Uncharacterized protein. (937 aa)
STRA8Stimulated by retinoic acid 8. (376 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CDT1Chromatin licensing and DNA replication factor 1. (641 aa)
LSM11LSM11, U7 small nuclear RNA associated. (399 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (899 aa)
ENSFCAP00000054808Uncharacterized protein. (786 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (591 aa)
MTBPMDM2 binding protein. (911 aa)
NSFL1CNSFL1 cofactor. (470 aa)
ENSFCAP00000053720UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (114 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4670 aa)
NKX3-1NK3 homeobox 1. (231 aa)
CDC27Cell division cycle 27. (839 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (408 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa)
GPSM2G protein signaling modulator 2. (767 aa)
HOXA13Homeobox A13. (389 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PRDM7Uncharacterized protein. (918 aa)
PCID2PCI domain containing 2. (399 aa)
FOXG1Forkhead box G1. (483 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
TFDP1Transcription factor. (423 aa)
TBX3T-box transcription factor 3. (745 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MSX1Msh homeobox 1. (303 aa)
OVOL1Ovo like transcriptional repressor 1. (415 aa)
ENSFCAP00000048496Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
DBF4BDBF4-type domain-containing protein. (307 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (337 aa)
CCNT1CYCLIN domain-containing protein; Belongs to the cyclin family. (184 aa)
PLK4Polo like kinase 4. (969 aa)
STXBP4Uncharacterized protein. (562 aa)
NUDT16Nudix hydrolase 16. (195 aa)
SHBSH2 domain-containing protein. (508 aa)
MAP3K20Uncharacterized protein. (800 aa)
SFPQSplicing factor proline and glutamine rich. (701 aa)
POLDIP2DNA polymerase delta interacting protein 2. (439 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
STOX1Storkhead box 1. (878 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (249 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (370 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (266 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
CRNNCornulin. (541 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
TPRTranslocated promoter region, nuclear basket protein. (2498 aa)
ZBED6CLDimer_Tnp_hAT domain-containing protein. (1076 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MAP10Microtubule associated protein 10. (902 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RAD51BRAD51 paralog B. (350 aa)
TGFATransforming growth factor alpha. (192 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
EPGNEpithelial mitogen. (153 aa)
TRIM21Tripartite motif containing 21. (469 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
ECT2Epithelial cell transforming 2. (914 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MARK4Non-specific serine/threonine protein kinase. (752 aa)
SMC2Structural maintenance of chromosomes 2. (1156 aa)
BTCBetacellulin. (194 aa)
HSF1Heat shock transcription factor 1. (527 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (221 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (281 aa)
GIPC2GIPC PDZ domain containing family member 2. (313 aa)
CDC14BUncharacterized protein. (529 aa)
ENSFCAP00000030965Protein kinase domain-containing protein. (104 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
ENSFCAP00000028934Uncharacterized protein. (225 aa)
DDX39BDExD-box helicase 39B. (428 aa)
FBXO42F-box protein 42. (717 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
RANBP1RAN binding protein 1. (278 aa)
ENSFCAP00000026963Uncharacterized protein. (73 aa)
CUL4BCullin 4B; Belongs to the cullin family. (911 aa)
ENSFCAP00000026456Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (128 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
ZNF112Uncharacterized protein. (915 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa)
RB1RB transcriptional corepressor 1. (930 aa)
CDC42-2Uncharacterized protein. (191 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa)
CDCA5Cell division cycle associated 5. (252 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
THOC1THO complex 1. (757 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
CDC7Cell division cycle 7. (574 aa)
CEP295Centrosomal protein 295. (2534 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (438 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PHB2Prohibitin. (299 aa)
RAD51CRAD51 paralog C. (362 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (350 aa)
CDC25CCell division cycle 25C. (477 aa)
NCAPGNon-SMC condensin I complex subunit G. (1015 aa)
FOXA1Forkhead box A1. (536 aa)
DBF4DBF4 zinc finger. (676 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (309 aa)
ANKRD31ANK_REP_REGION domain-containing protein. (714 aa)
PKN2Protein kinase N2. (983 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
EREGEpiregulin. (169 aa)
LOC101084379Homeobox domain-containing protein. (290 aa)
TRIM32Uncharacterized protein. (669 aa)
PAGR1PAXIP1 associated glutamate rich protein 1. (254 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
RHOARas homolog family member A. (193 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (363 aa)
M3WTU8_FELCAUncharacterized protein. (84 aa)
ATRXATRX chromatin remodeler. (2486 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
M3WSW9_FELCAUncharacterized protein. (162 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (243 aa)
PROX1Prospero homeobox 1. (737 aa)
NDC80NDC80 kinetochore complex component. (647 aa)
MEIOCMeiosis specific with coiled-coil domain. (960 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
KLHL18Kelch like family member 18. (574 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
INO80INO80 complex ATPase subunit. (1620 aa)
CDC16Cell division cycle 16. (620 aa)
PBKPDZ binding kinase. (337 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
CUL4ACullin 4A; Belongs to the cullin family. (761 aa)
ANKRD17Ankyrin repeat domain 17. (2608 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (891 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
GIPC1GIPC PDZ domain containing family member 1. (447 aa)
RAD21RAD21 cohesin complex component. (631 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
BECN1Beclin 1. (448 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (653 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
NUSAP1Nucleolar and spindle associated protein 1. (446 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
STILSTIL centriolar assembly protein. (1302 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ZPR1ZPR1 zinc finger. (459 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
MEPCEMethylphosphate capping enzyme. (689 aa)
E2F7E2F transcription factor 7. (910 aa)
E2F8E2F transcription factor 8. (864 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
MAD2L1BPMAD2L1 binding protein. (274 aa)
SOX15SRY-box 15. (233 aa)
RACGAP1Rac GTPase activating protein 1. (668 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1139 aa)
TBX2T-box transcription factor 2. (713 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
CDC25ACell division cycle 25A. (524 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (556 aa)
SPAG5Sperm associated antigen 5. (1194 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
LGMNLegumain. (433 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (684 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
NRMNurim. (262 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (955 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
OOEPOocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family. (149 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (378 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
TGM1Transglutaminase 1. (820 aa)
SPHK1Sphingosine kinase 1. (473 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (916 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
CENPJCentromere protein J. (1354 aa)
CDC42Uncharacterized protein. (191 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
THOC5THO complex 5. (683 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (393 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
GLI1GLI family zinc finger 1. (1105 aa)
NUP62CLNsp1_C domain-containing protein. (215 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
LOC101099765Uncharacterized protein. (226 aa)
CDC23Cell division cycle 23. (547 aa)
NANOGNanog homeobox. (311 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
CITCitron rho-interacting serine/threonine kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1882 aa)
CDC73Cell division cycle 73. (531 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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