(26 nodes) Negative regulation of endocytosis network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANKRD13A	Ankyrin repeat domain 13A. (590 aa)
	LOC101088701	Ig-like domain-containing protein. (370 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (525 aa)
	PPCDC	Secretory carrier-associated membrane protein. (330 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (498 aa)
	ANKRD13B	Ankyrin repeat domain 13B. (664 aa)
	SNX33	Sorting nexin. (577 aa)
	ANKRD13D	Ankyrin repeat domain 13D. (607 aa)
	WDR54	WD repeat domain 54. (349 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (457 aa)
	PROM2	Prominin 2. (837 aa)
	PACSIN3	Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
	LRPAP1	LDL receptor related protein associated protein 1. (417 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (283 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
	RIN3	Ras and Rab interactor 3. (982 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	LRRTM1	Leucine rich repeat transmembrane neuronal 1. (522 aa)
	LRSAM1	Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	RABGEF1	Uncharacterized protein. (491 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	RUBCN	Rubicon autophagy regulator. (1014 aa)
	NEU3	Neuraminidase 3. (438 aa)
	LGALS3	Galectin. (278 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CAV1	ENSFCAP00000012876	ENSFCAP00000029296	Adiponectin, C1Q and collagen domain containing.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.437
CAV1	ADIPOQ	ENSFCAP00000029296	ENSFCAP00000012876	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Adiponectin, C1Q and collagen domain containing.	0.437
CAV1	ITGB3	ENSFCAP00000029296	ENSFCAP00000033446	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Integrin beta; Belongs to the integrin beta chain family.	0.933
CAV1	PACSIN2	ENSFCAP00000029296	ENSFCAP00000044879	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Protein kinase C and casein kinase substrate in neurons 2.	0.665
ITGAV	ITGB3	ENSFCAP00000051326	ENSFCAP00000033446	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999
ITGB3	CAV1	ENSFCAP00000033446	ENSFCAP00000029296	Integrin beta; Belongs to the integrin beta chain family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.933
ITGB3	ITGAV	ENSFCAP00000033446	ENSFCAP00000051326	Integrin beta; Belongs to the integrin beta chain family.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.999
NR1H2	NR1H3	ENSFCAP00000008507	ENSFCAP00000051861	Nuclear receptor subfamily 1 group H member 2.	Nuclear receptor subfamily 1 group H member 3.	0.944
NR1H3	NR1H2	ENSFCAP00000051861	ENSFCAP00000008507	Nuclear receptor subfamily 1 group H member 3.	Nuclear receptor subfamily 1 group H member 2.	0.944
PACSIN1	PACSIN2	ENSFCAP00000014239	ENSFCAP00000044879	Protein kinase C and casein kinase substrate in neurons 1.	Protein kinase C and casein kinase substrate in neurons 2.	0.836
PACSIN1	PACSIN3	ENSFCAP00000014239	ENSFCAP00000011715	Protein kinase C and casein kinase substrate in neurons 1.	Protein kinase C and casein kinase substrate in neurons 3.	0.850
PACSIN2	CAV1	ENSFCAP00000044879	ENSFCAP00000029296	Protein kinase C and casein kinase substrate in neurons 2.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.665
PACSIN2	PACSIN1	ENSFCAP00000044879	ENSFCAP00000014239	Protein kinase C and casein kinase substrate in neurons 2.	Protein kinase C and casein kinase substrate in neurons 1.	0.836
PACSIN2	PACSIN3	ENSFCAP00000044879	ENSFCAP00000011715	Protein kinase C and casein kinase substrate in neurons 2.	Protein kinase C and casein kinase substrate in neurons 3.	0.854
PACSIN2	SNX33	ENSFCAP00000044879	ENSFCAP00000057729	Protein kinase C and casein kinase substrate in neurons 2.	Sorting nexin.	0.509
PACSIN3	PACSIN1	ENSFCAP00000011715	ENSFCAP00000014239	Protein kinase C and casein kinase substrate in neurons 3.	Protein kinase C and casein kinase substrate in neurons 1.	0.850
PACSIN3	PACSIN2	ENSFCAP00000011715	ENSFCAP00000044879	Protein kinase C and casein kinase substrate in neurons 3.	Protein kinase C and casein kinase substrate in neurons 2.	0.854
RABGEF1	RIN3	ENSFCAP00000031131	ENSFCAP00000018436	Uncharacterized protein.	Ras and Rab interactor 3.	0.631
RIN3	RABGEF1	ENSFCAP00000018436	ENSFCAP00000031131	Ras and Rab interactor 3.	Uncharacterized protein.	0.631
SNX33	PACSIN2	ENSFCAP00000057729	ENSFCAP00000044879	Sorting nexin.	Protein kinase C and casein kinase substrate in neurons 2.	0.509