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RNFT2 | Ring finger protein, transmembrane 2. (445 aa) | ||||
GBA | Glucosylceramidase. (536 aa) | ||||
WDR20 | WD repeat domain 20. (588 aa) | ||||
PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) | ||||
FBXW7 | F-box and WD repeat domain containing 7. (749 aa) | ||||
BAX | BCL2 associated X, apoptosis regulator. (192 aa) | ||||
SOCS5 | Suppressor of cytokine signaling 5. (536 aa) | ||||
TNFSF15 | TNF superfamily member 15. (255 aa) | ||||
RCN3 | Reticulocalbin 3. (328 aa) | ||||
SOCS4 | Suppressor of cytokine signaling 4. (441 aa) | ||||
OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa) | ||||
ENSFCAP00000030321 | Uncharacterized protein. (79 aa) | ||||
ENSFCAP00000030418 | KH type-2 domain-containing protein. (147 aa) | ||||
HPN | Hepsin; Belongs to the peptidase S1 family. (571 aa) | ||||
SOX7 | Uncharacterized protein. (571 aa) | ||||
ENSFCAP00000031202 | Uncharacterized protein. (94 aa) | ||||
CARD9 | Caspase recruitment domain family member 9. (732 aa) | ||||
CASP2 | Caspase 2; Belongs to the peptidase C14A family. (451 aa) | ||||
FBXW9 | F-box and WD repeat domain containing 9. (458 aa) | ||||
CDC20 | Cell division cycle 20. (499 aa) | ||||
FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) | ||||
DIABLO | Uncharacterized protein. (237 aa) | ||||
TANK | TRAF family member associated NFKB activator. (445 aa) | ||||
RCHY1 | Ring finger and CHY zinc finger domain containing 1. (264 aa) | ||||
SPON1 | Spondin 1. (807 aa) | ||||
DET1 | DET1 partner of COP1 E3 ubiquitin ligase. (560 aa) | ||||
SMAD3 | Mothers against decapentaplegic homolog. (457 aa) | ||||
PDCD2 | Programmed cell death 2. (344 aa) | ||||
RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) | ||||
TNP1 | Transition protein 1. (55 aa) | ||||
PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) | ||||
LOC101098213 | Cytochrome c. (105 aa) | ||||
TRIB3 | Tribbles pseudokinase 3. (357 aa) | ||||
CASP8AP2 | Caspase 8 associated protein 2. (1779 aa) | ||||
LOC101101321 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (457 aa) | ||||
NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) | ||||
ADAM8 | ADAM metallopeptidase domain 8. (872 aa) | ||||
TRIB2 | Tribbles pseudokinase 2. (343 aa) | ||||
FGL2 | Fibrinogen like 2. (440 aa) | ||||
SFRP2 | Secreted frizzled related protein 2. (385 aa) | ||||
FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) | ||||
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) | ||||
MKRN2 | Makorin ring finger protein 2. (416 aa) | ||||
P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa) | ||||
LGMN | Legumain. (433 aa) | ||||
EPHA4 | EPH receptor A4. (986 aa) | ||||
DVL1 | Dishevelled segment polarity protein 1. (700 aa) | ||||
ENSFCAP00000030239 | Uncharacterized protein. (145 aa) | ||||
HTRA2 | HtrA serine peptidase 2. (458 aa) | ||||
KCNE2 | Potassium voltage-gated channel subfamily E regulatory subunit 2. (182 aa) | ||||
CNTN2 | Contactin 2. (1103 aa) | ||||
HIP1R | Huntingtin interacting protein 1 related. (1068 aa) | ||||
NLRC4 | NLR family CARD domain containing 4. (1022 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) | ||||
ZER1 | Zyg-11 related cell cycle regulator. (766 aa) | ||||
RNFT1 | Ring finger protein, transmembrane 1. (435 aa) | ||||
PSME1 | Proteasome activator subunit 1. (249 aa) | ||||
DAPK1 | Death associated protein kinase 1. (1429 aa) | ||||
CLDN4 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa) | ||||
CASP10 | Caspase 10; Belongs to the peptidase C14A family. (482 aa) | ||||
TRIB1 | Tribbles pseudokinase 1. (372 aa) | ||||
AGER | Advanced glycosylation end-product specific receptor. (492 aa) | ||||
BAG6 | BCL2 associated athanogene 6. (1184 aa) | ||||
HSPA1L | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa) | ||||
CCDC22 | Coiled-coil domain containing 22. (631 aa) | ||||
NUB1 | Negative regulator of ubiquitin like proteins 1. (639 aa) | ||||
TMEM259 | Transmembrane protein 259. (681 aa) | ||||
HSPBP1 | HSPA (Hsp70) binding protein 1. (374 aa) | ||||
PCOLCE2 | Procollagen C-endopeptidase enhancer 2. (433 aa) | ||||
RNF139 | Ring finger protein 139. (983 aa) | ||||
FAM162A | Family with sequence similarity 162 member A. (167 aa) | ||||
ENSFCAP00000059958 | Uncharacterized protein. (162 aa) | ||||
MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (568 aa) | ||||
MAGEF1 | MAGE family member F1. (316 aa) | ||||
BAK1 | BCL2 antagonist/killer 1. (251 aa) | ||||
EFNA1 | Ephrin A1; Belongs to the ephrin family. (357 aa) | ||||
PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa) | ||||
CLEC7A | C-type lectin domain containing 7A. (250 aa) | ||||
F12 | Coagulation factor XII. (639 aa) | ||||
UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1454 aa) | ||||
CTSH | Cathepsin H; Belongs to the peptidase C1 family. (572 aa) | ||||
HMGB1 | Uncharacterized protein. (233 aa) | ||||
SNX33 | Sorting nexin. (577 aa) | ||||
ARIH2 | RBR-type E3 ubiquitin transferase. (501 aa) | ||||
GRN | Granulin precursor. (596 aa) | ||||
FOXL2 | Forkhead box L2. (357 aa) | ||||
BOK | BCL2 family apoptosis regulator BOK. (320 aa) | ||||
ASTL | Metalloendopeptidase. (425 aa) | ||||
DAP | Uncharacterized protein. (165 aa) | ||||
GRAMD4 | GRAM domain containing 4. (743 aa) | ||||
ZYG11B | Zyg-11 family member B, cell cycle regulator. (750 aa) | ||||
NOP53 | NOP53 ribosome biogenesis factor. (485 aa) | ||||
TNIP3 | TNFAIP3 interacting protein 3. (397 aa) | ||||
GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (873 aa) | ||||
RNF144A | RBR-type E3 ubiquitin transferase. (534 aa) | ||||
SIRT2 | Sirtuin 2. (497 aa) | ||||
MTCH1 | Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (542 aa) | ||||
BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) | ||||
RHBDD1 | Rhomboid domain containing 1. (320 aa) | ||||
OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (956 aa) | ||||
ENSFCAP00000055271 | PID domain-containing protein. (114 aa) | ||||
CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) | ||||
PIDD1 | P53-induced death domain protein 1. (940 aa) | ||||
PIAS1 | Protein inhibitor of activated STAT 1. (664 aa) | ||||
FBXW8 | F-box and WD repeat domain containing 8. (701 aa) | ||||
AGBL4 | ATP/GTP binding protein like 4. (503 aa) | ||||
PCOLCE | Procollagen C-endopeptidase enhancer. (559 aa) | ||||
NKD2 | NKD inhibitor of WNT signaling pathway 2. (488 aa) | ||||
SH3D19 | SH3 domain containing 19. (1048 aa) | ||||
RNF217 | Ring finger protein 217. (621 aa) | ||||
GSN | Gelsolin. (815 aa) | ||||
CBFA2T3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (758 aa) | ||||
ENSFCAP00000053469 | PA28_beta domain-containing protein. (192 aa) | ||||
NKX3-1 | NK3 homeobox 1. (231 aa) | ||||
CYFIP2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1335 aa) | ||||
APH1B | Uncharacterized protein. (516 aa) | ||||
LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (625 aa) | ||||
USP5 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (891 aa) | ||||
BCAP31 | B cell receptor associated protein 31. (370 aa) | ||||
MELTF | Melanotransferrin; Belongs to the transferrin family. (744 aa) | ||||
TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) | ||||
NEK5 | NIMA related kinase 5. (825 aa) | ||||
TNP2 | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (119 aa) | ||||
RNF19B | RBR-type E3 ubiquitin transferase. (734 aa) | ||||
PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) | ||||
F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa) | ||||
S100A9 | Protein S100; Belongs to the S-100 family. (135 aa) | ||||
PML | Promyelocytic leukemia. (876 aa) | ||||
RACK1 | WD_REPEATS_REGION domain-containing protein. (424 aa) | ||||
TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) | ||||
ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) | ||||
TFAP4 | Transcription factor AP-4. (337 aa) | ||||
PDCD6 | Programmed cell death 6. (189 aa) | ||||
BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) | ||||
SRC | Tyrosine-protein kinase. (678 aa) | ||||
ENSFCAP00000041674 | AAA domain-containing protein; Belongs to the AAA ATPase family. (189 aa) | ||||
REST | RE1 silencing transcription factor. (1045 aa) | ||||
ENSFCAP00000041941 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (620 aa) | ||||
CDC20B | Cell division cycle 20B. (520 aa) | ||||
SMAD7 | Mothers against decapentaplegic homolog. (426 aa) | ||||
PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa) | ||||
PLGRKT | Plasminogen receptor with a C-terminal lysine. (147 aa) | ||||
PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) | ||||
BAG2 | BCL2 associated athanogene 2. (211 aa) | ||||
CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa) | ||||
GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa) | ||||
GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) | ||||
PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) | ||||
PDCD5 | Programmed cell death 5. (197 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (770 aa) | ||||
ZYG11A | Zyg-11 family member A, cell cycle regulator. (756 aa) | ||||
DNAJB2 | DnaJ heat shock protein family (Hsp40) member B2. (325 aa) | ||||
PSME3 | Uncharacterized protein. (265 aa) | ||||
TTBK1 | Tau tubulin kinase 1. (1314 aa) | ||||
TNFSF10 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa) | ||||
COP1 | COP1 E3 ubiquitin ligase. (728 aa) | ||||
PSME2 | Proteasome activator subunit 2. (253 aa) | ||||
EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) | ||||
PYCARD | PYD and CARD domain containing. (195 aa) | ||||
BCL10 | BCL10 immune signaling adaptor. (233 aa) | ||||
HIP1 | Huntingtin interacting protein 1. (1036 aa) | ||||
CCBE1 | Collagen and calcium binding EGF domains 1. (440 aa) | ||||
SIRT6 | Sirtuin 6. (412 aa) | ||||
FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa) | ||||
BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa) | ||||
PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) | ||||
FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) | ||||
ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa) | ||||
DAB2 | DAB adaptor protein 2. (769 aa) | ||||
LOC101082405 | AAA domain-containing protein. (330 aa) | ||||
PSME4 | Proteasome activator subunit 4. (1865 aa) | ||||
MAPK9 | Mitogen-activated protein kinase. (424 aa) | ||||
BAD | BCL2 associated agonist of cell death. (273 aa) | ||||
NCSTN | Nicastrin. (709 aa) | ||||
CLDN3 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) | ||||
BBC3 | Uncharacterized protein. (193 aa) | ||||
AGTPBP1 | ATP/GTP binding protein 1. (1227 aa) | ||||
MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) | ||||
EGLN3 | Egl-9 family hypoxia inducible factor 3. (239 aa) | ||||
TMEM130 | Transmembrane protein 130. (475 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) | ||||
APH1A | Aph-1 homolog A, gamma-secretase subunit. (330 aa) | ||||
TRIM67 | Tripartite motif containing 67. (783 aa) | ||||
SENP1 | SUMO specific peptidase 1. (745 aa) | ||||
RNF185 | Ring finger protein 185. (192 aa) | ||||
CSNK1D | Casein kinase 1 delta. (488 aa) | ||||
NGFR | Nerve growth factor receptor. (421 aa) | ||||
CAPN3 | Calpain 3; Belongs to the peptidase C2 family. (821 aa) | ||||
SART3 | Spliceosome associated factor 3, U4/U6 recycling protein. (982 aa) | ||||
FN1 | Fibronectin 1. (2475 aa) | ||||
CLUL1 | Clusterin; Belongs to the clusterin family. (468 aa) | ||||
S100A10 | S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa) | ||||
SNX9 | Sorting nexin 9. (678 aa) | ||||
RNF19A | RBR-type E3 ubiquitin transferase. (838 aa) | ||||
LRRK2 | Leucine rich repeat kinase 2. (2527 aa) | ||||
PRELID1 | PRELI domain containing 1. (219 aa) | ||||
S100A8 | Protein S100; Belongs to the S-100 family. (124 aa) | ||||
NODAL | Nodal growth differentiation factor. (348 aa) | ||||
RNF144B | RBR-type E3 ubiquitin transferase. (341 aa) | ||||
ANGPTL8 | Angiopoietin like 8. (198 aa) | ||||
ACVR1C | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa) | ||||
IST1 | IST1 factor associated with ESCRT-III. (366 aa) | ||||
SH3RF3 | SH3 domain containing ring finger 3. (878 aa) | ||||
CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) | ||||
DDA1 | DET1 and DDB1 associated 1. (102 aa) | ||||
DAB2IP | DAB2 interacting protein. (1166 aa) | ||||
ENSFCAP00000028212 | Uncharacterized protein. (83 aa) | ||||
AXIN1 | Axin 1. (867 aa) | ||||
SIRT1 | Sirtuin 1. (745 aa) | ||||
ENSFCAP00000027525 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
ENSFCAP00000027328 | Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (103 aa) | ||||
TBC1D10A | TBC1 domain family member 10A. (517 aa) | ||||
RPS3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) | ||||
NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) | ||||
PACSIN3 | Protein kinase C and casein kinase substrate in neurons 3. (424 aa) | ||||
F3 | Coagulation factor III, tissue factor. (379 aa) | ||||
TNIP1 | TNFAIP3 interacting protein 1. (635 aa) | ||||
PLK1 | Serine/threonine-protein kinase PLK. (604 aa) | ||||
VSIR | V-set immunoregulatory receptor. (311 aa) | ||||
FBXO22 | F-box protein 22. (409 aa) | ||||
MALT1 | MALT1 paracaspase. (848 aa) | ||||
SYK | Spleen associated tyrosine kinase. (636 aa) | ||||
NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13. (144 aa) | ||||
CLU | Clusterin; Belongs to the clusterin family. (469 aa) | ||||
PRICKLE1 | Prickle planar cell polarity protein 1. (830 aa) | ||||
SMURF1 | E3 ubiquitin-protein ligase. (757 aa) | ||||
SGTA | Small glutamine rich tetratricopeptide repeat containing alpha. (334 aa) | ||||
FGFR4 | Fibroblast growth factor receptor. (830 aa) | ||||
ANP32B | Acidic nuclear phosphoprotein 32 family member B. (253 aa) | ||||
ARIH1 | RBR-type E3 ubiquitin transferase. (555 aa) | ||||
PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) | ||||
TMTC3 | Transmembrane O-mannosyltransferase targeting cadherins 3. (915 aa) | ||||
ASPH | Aspartate beta-hydroxylase. (692 aa) | ||||
CAPN9 | Calpain 9; Belongs to the peptidase C2 family. (690 aa) | ||||
FAS | Uncharacterized protein. (314 aa) | ||||
NRDC | Nardilysin convertase. (1226 aa) | ||||
PRR7 | Proline rich 7, synaptic. (269 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) | ||||
AURKAIP1 | Aurora kinase A interacting protein 1. (199 aa) | ||||
USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa) | ||||
LAPTM5 | Lysosomal protein transmembrane 5. (263 aa) | ||||
AXIN2 | Axin 2. (841 aa) | ||||
ANKIB1 | RBR-type E3 ubiquitin transferase. (1091 aa) | ||||
RNF180 | Ring finger protein 180. (580 aa) | ||||
LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
BBS7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa) | ||||
GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa) | ||||
LYN | Tyrosine-protein kinase. (526 aa) | ||||
WDR48 | WD repeat domain 48. (677 aa) | ||||
PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) | ||||
DDRGK1 | DDRGK domain containing 1. (340 aa) | ||||
NLRP3 | NLR family pyrin domain containing 3. (1038 aa) | ||||
M3X1N0_FELCA | Uncharacterized protein. (276 aa) | ||||
RAD23A | RAD23 homolog A, nucleotide excision repair protein. (362 aa) | ||||
CLPX | Caseinolytic mitochondrial matrix peptidase chaperone subunit. (633 aa) | ||||
HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (393 aa) | ||||
DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa) | ||||
CIDEB | Cell death inducing DFFA like effector b. (221 aa) | ||||
PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) | ||||
CCN1 | Cellular communication network factor 1. (382 aa) | ||||
NLRP6 | NLR family pyrin domain containing 6. (878 aa) | ||||
CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) | ||||
TRIM32 | Uncharacterized protein. (669 aa) | ||||
SH3RF1 | SH3 domain containing ring finger 1. (889 aa) | ||||
IFT57 | Intraflagellar transport 57. (429 aa) | ||||
PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) | ||||
CLN6 | CLN6 transmembrane ER protein. (312 aa) | ||||
STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) | ||||
AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) | ||||
USP50 | Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (372 aa) | ||||
SH3RF2 | SH3 domain containing ring finger 2. (734 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) | ||||
MYH9 | Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa) | ||||
PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |