STRINGSTRING
PRKAR1A PRKAR1A SCRIB SCRIB CRTAM CRTAM IDO1 IDO1 LRRC32 LRRC32 LRRC1 LRRC1 LOC101082108 LOC101082108 PRKAR1B PRKAR1B PRNP PRNP CASP3 CASP3 RC3H1 RC3H1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.