STRINGSTRING
GPR17 GPR17 SPRY1 SPRY1 ARFGEF3 ARFGEF3 COL3A1 COL3A1 FBXO8 FBXO8 HEG1 HEG1 DENND3 DENND3 ARFGEF1 ARFGEF1 RASAL3 RASAL3 KRAS KRAS SH3BP1 SH3BP1 SSX2IP SSX2IP STMN3 STMN3 BCR BCR GPR35 GPR35 CBL CBL LOC111558710 LOC111558710 ITPKB ITPKB LPAR1 LPAR1 ARHGAP24 ARHGAP24 NOTCH1 NOTCH1 KIF14 KIF14 FOXM1 FOXM1 GPR20 GPR20 EPS8L1 EPS8L1 TNFAIP1 TNFAIP1 RASGRF2 RASGRF2 GPR18 GPR18 SYDE2 SYDE2 ARAP3 ARAP3 SPRY3 SPRY3 GPR55 GPR55 M3XEZ6_FELCA M3XEZ6_FELCA LRRC59 LRRC59 KCTD13 KCTD13 MFN2 MFN2 PIK3CB PIK3CB ARHGEF25 ARHGEF25 RTN4R RTN4R MADD MADD ARHGEF3 ARHGEF3 ARHGDIA ARHGDIA OGT OGT GIT1 GIT1 ARHGEF28 ARHGEF28 RABGEF1 RABGEF1 RIPOR3 RIPOR3 RASA2 RASA2 ARHGAP42 ARHGAP42 SMIM10L1 SMIM10L1 ITGB1 ITGB1 MYOC MYOC FGF10 FGF10 KBTBD6 KBTBD6 ARHGDIB ARHGDIB ARHGEF2 ARHGEF2 MAPRE2 MAPRE2 AKAP13 AKAP13 PSD3 PSD3 ABRA ABRA P2RY10 P2RY10 KANK2 KANK2 SYDE1 SYDE1 DENND4A DENND4A SYNPO2L SYNPO2L RAPGEF1 RAPGEF1 RABL3 RABL3 PSD2 PSD2 NET1 NET1 LRRD1 LRRD1 MAPKAP1 MAPKAP1 RASA1 RASA1 RASA4B RASA4B CAVIN4 CAVIN4 FLCN FLCN EPS8 EPS8 F11R F11R CUL3 CUL3 F2RL2 F2RL2 SCAI SCAI CYTH1 CYTH1 ARHGAP35 ARHGAP35 TRIM67 TRIM67 DGKI DGKI ENSFCAP00000046279 ENSFCAP00000046279 RASAL1 RASAL1 ARHGEF18 ARHGEF18 NTRK1 NTRK1 RASGEF1A RASGEF1A ARFGAP1 ARFGAP1 AUTS2 AUTS2 KCTD10 KCTD10 SHOC2 SHOC2 ARHGAP17 ARHGAP17 SYNGAP1 SYNGAP1 PSD PSD IQSEC2 IQSEC2 SGSM3 SGSM3 OPHN1 OPHN1 ENSFCAP00000051698 ENSFCAP00000051698 LRRC7 LRRC7 ARHGAP44 ARHGAP44 RIPOR2 RIPOR2 ADGRG1 ADGRG1 GBF1 GBF1 ENSFCAP00000054404 ENSFCAP00000054404 F2RL3 F2RL3 RASGRF1 RASGRF1 DENND4B DENND4B EPS8L2 EPS8L2 LOC111561928 LOC111561928 LPAR6 LPAR6 RASGRP1 RASGRP1 NF1 NF1 DLC1 DLC1 CYTH4 CYTH4 MCF2L MCF2L CYTH3 CYTH3 CDC42SE2 CDC42SE2 GIT2 GIT2 ARF6 ARF6 EPS8L3 EPS8L3 KANK1 KANK1 IQSEC1 IQSEC1 MET MET IQSEC3 IQSEC3 PRAG1 PRAG1 STARD13 STARD13 STARD8 STARD8 CDC42SE1 CDC42SE1 RASGRP4 RASGRP4 MYO9B MYO9B ARFGEF2 ARFGEF2 DENND4C DENND4C NUP62CL NUP62CL CYTH2 CYTH2 CCDC125 CCDC125 P2RY8 P2RY8 F2R F2R SPRY4 SPRY4 ABCA1 ABCA1 PIK3CG PIK3CG ITGA3 ITGA3 ABL1 ABL1 LZTR1 LZTR1 NRP1 NRP1 PLCE1 PLCE1 KBTBD7 KBTBD7 BCL6 BCL6 EPO EPO RASIP1 RASIP1 FLOT1 FLOT1 SPRY2 SPRY2 RALGPS1 RALGPS1 FBP1 FBP1 PSD4 PSD4 NOTCH2 NOTCH2 CSF1 CSF1 STAMBP STAMBP RALGPS2 RALGPS2 ARHGEF10 ARHGEF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa)
SPRY1Sprouty RTK signaling antagonist 1. (362 aa)
ARFGEF3ARFGEF family member 3. (2177 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
FBXO8F-box protein 8. (319 aa)
HEG1Heart development protein with EGF like domains 1. (1374 aa)
DENND3DENN domain containing 3. (1272 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
RASAL3RAS protein activator like 3. (1012 aa)
KRASUncharacterized protein. (380 aa)
SH3BP1Uncharacterized protein. (734 aa)
SSX2IPSSX family member 2 interacting protein. (618 aa)
STMN3Stathmin; Belongs to the stathmin family. (180 aa)
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (395 aa)
CBLCbl proto-oncogene. (902 aa)
LOC111558710Uncharacterized protein. (78 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ARHGAP24Rho GTPase activating protein 24. (749 aa)
NOTCH1Notch receptor 1. (2543 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa)
FOXM1Forkhead box M1. (763 aa)
GPR20G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (366 aa)
EPS8L1EPS8 like 1. (777 aa)
TNFAIP1TNF alpha induced protein 1. (316 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1239 aa)
GPR18G protein-coupled receptor 18. (331 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1379 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1544 aa)
SPRY3Sprouty RTK signaling antagonist 3. (288 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
M3XEZ6_FELCAUncharacterized protein. (183 aa)
LRRC59Leucine rich repeat containing 59. (306 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ARHGEF25DH domain-containing protein. (619 aa)
RTN4RReticulon 4 receptor. (474 aa)
MADDMAP kinase activating death domain. (1647 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (618 aa)
ARHGDIAUncharacterized protein. (425 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
GIT1GIT ArfGAP 1. (770 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1706 aa)
RABGEF1Uncharacterized protein. (491 aa)
RIPOR3RIPOR family member 3. (951 aa)
RASA2RAS p21 protein activator 2. (854 aa)
ARHGAP42Rho GTPase activating protein 42. (874 aa)
SMIM10L1Small integral membrane protein 10 like 1. (68 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (498 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
KBTBD6Kelch repeat and BTB domain containing 6. (706 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1181 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (326 aa)
AKAP13Uncharacterized protein. (1431 aa)
PSD3Pleckstrin and Sec7 domain containing 3. (1347 aa)
ABRAActin binding Rho activating protein. (372 aa)
P2RY10P2Y receptor family member 10. (389 aa)
KANK2KN motif and ankyrin repeat domains 2. (857 aa)
SYDE1Synapse defective Rho GTPase homolog 1. (668 aa)
DENND4ADENN domain containing 4A. (1917 aa)
SYNPO2LSynaptopodin 2 like. (973 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
RABL3RAB, member of RAS oncogene family like 3. (264 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (774 aa)
NET1Neuroepithelial cell transforming 1. (591 aa)
LRRD1Uncharacterized protein. (229 aa)
MAPKAP1MAPK associated protein 1. (575 aa)
RASA1RAS p21 protein activator 1. (1039 aa)
RASA4BUncharacterized protein. (801 aa)
CAVIN4Caveolae associated protein 4. (362 aa)
FLCNUncharacterized protein. (579 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
F11RJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...] (378 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
F2RL2Coagulation factor II thrombin receptor like 2. (378 aa)
SCAIProtein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (606 aa)
CYTH1Cytohesin 1. (412 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
TRIM67Tripartite motif containing 67. (783 aa)
DGKIDiacylglycerol kinase. (1082 aa)
ENSFCAP00000046279Uncharacterized protein. (227 aa)
RASAL1RAS protein activator like 1. (812 aa)
ARHGEF18Uncharacterized protein. (1357 aa)
NTRK1Tyrosine-protein kinase receptor. (770 aa)
RASGEF1ARasGEF domain family member 1A. (488 aa)
ARFGAP1ADP ribosylation factor GTPase activating protein 1. (424 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1258 aa)
KCTD10Potassium channel tetramerization domain containing 10. (369 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
ARHGAP17Rho GTPase activating protein 17. (863 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
PSDPleckstrin and Sec7 domain containing. (1098 aa)
IQSEC2IQ motif and Sec7 domain 2. (1520 aa)
SGSM3Small G protein signaling modulator 3. (805 aa)
OPHN1Oligophrenin 1. (823 aa)
ENSFCAP00000051698Uncharacterized protein. (205 aa)
LRRC7Leucine rich repeat containing 7. (1575 aa)
ARHGAP44Rho GTPase activating protein 44. (859 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1162 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (689 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1970 aa)
ENSFCAP00000054404Uncharacterized protein. (284 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (401 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1312 aa)
DENND4BDENN domain containing 4B. (1494 aa)
EPS8L2EPS8 like 2. (748 aa)
LOC111561928G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
LPAR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
NF1Neurofibromin 1. (2856 aa)
DLC1DLC1 Rho GTPase activating protein. (1526 aa)
CYTH4Cytohesin 4. (443 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1196 aa)
CYTH3Cytohesin 3. (648 aa)
CDC42SE2CRIB domain-containing protein. (271 aa)
GIT2GIT ArfGAP 2. (786 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (140 aa)
EPS8L3EPS8 like 3. (594 aa)
KANK1KN motif and ankyrin repeat domains 1. (1366 aa)
IQSEC1IQ motif and Sec7 domain 1. (1057 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
IQSEC3IQ motif and Sec7 domain 3. (1237 aa)
PRAG1PEAK1 related, kinase-activating pseudokinase 1. (1401 aa)
STARD13StAR related lipid transfer domain containing 13. (1127 aa)
STARD8StAR related lipid transfer domain containing 8. (1175 aa)
CDC42SE1CRIB domain-containing protein. (79 aa)
RASGRP4RAS guanyl releasing protein 4. (671 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2162 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
DENND4CDENN domain containing 4C. (1957 aa)
NUP62CLNsp1_C domain-containing protein. (215 aa)
CYTH2Uncharacterized protein. (400 aa)
CCDC125Coiled-coil domain containing 125. (515 aa)
P2RY8P2Y receptor family member 8; Belongs to the G-protein coupled receptor 1 family. (357 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LZTR1Leucine zipper like transcription regulator 1. (839 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
KBTBD7Kelch repeat and BTB domain containing 7. (679 aa)
BCL6BCL6 transcription repressor. (745 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
RASIP1Ras interacting protein 1. (943 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PSD4Pleckstrin and Sec7 domain containing 4. (1014 aa)
NOTCH2Notch receptor 2. (2493 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
STAMBPSTAM binding protein. (424 aa)
RALGPS2Ral GEF with PH domain and SH3 binding motif 2. (583 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1359 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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