STRINGSTRING
CLEC4G CLEC4G MYB MYB BCL6 BCL6 CD81 CD81 ZC3H12A ZC3H12A ITCH ITCH IFNG IFNG LGALS9 LGALS9 TYK2 TYK2 TBX21 TBX21 IL12A IL12A GLI3 GLI3 IL23A IL23A IL27 IL27 ZNF683 ZNF683 VSIR VSIR IRF1 IRF1 IL2 IL2 MALT1 MALT1 ARG2 ARG2 SYK SYK CD28 CD28 RASAL3 RASAL3 RIPK2 RIPK2 ZBTB7B ZBTB7B IHH IHH SH3RF1 SH3RF1 ITPKB ITPKB ZBTB16 ZBTB16 NLRP3 NLRP3 TWSG1 TWSG1 LOC101082108 LOC101082108 ADORA2A ADORA2A IL12B IL12B CBLB CBLB IL18 IL18 CD83 CD83 HLX HLX CARD11 CARD11 PRDM1 PRDM1 PRKCQ PRKCQ LOC101088701 LOC101088701 NCKAP1L NCKAP1L SMAD7 SMAD7 FOXP3 FOXP3 GATA3 GATA3 CBFB CBFB RC3H2 RC3H2 SHB SHB RC3H1 RC3H1 SOCS1 SOCS1 LOC101100430 LOC101100430 LOC101081130 LOC101081130 IL2RG IL2RG MAPK8IP1 MAPK8IP1 NDFIP1 NDFIP1 NFKBIZ NFKBIZ LOC101083890 LOC101083890 PRKCZ PRKCZ PTPRC PTPRC CD160 CD160 ADA ADA HMGB1 HMGB1 ENSFCAP00000060822 ENSFCAP00000060822 ANXA1 ANXA1 SHH SHH CCL19 CCL19 PTPN22 PTPN22 HFE HFE IL4 IL4 AGER AGER SASH3 SASH3 IL2RA IL2RA SOCS5 SOCS5 CRTAM CRTAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLEC4GC-type lectin domain family 4 member G. (317 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
BCL6BCL6 transcription repressor. (745 aa)
CD81Tetraspanin. (236 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
LGALS9Galectin. (356 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
TBX21T-box transcription factor 21. (535 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GLI3GLI family zinc finger 3. (1578 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
IL27Interleukin 27. (236 aa)
ZNF683Zinc finger protein 683. (600 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
IRF1Interferon regulatory factor. (322 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
MALT1MALT1 paracaspase. (848 aa)
ARG2Arginase. (354 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
RASAL3RAS protein activator like 3. (1012 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ZBTB7BUncharacterized protein. (540 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
SH3RF1SH3 domain containing ring finger 1. (889 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa)
ZBTB16Zinc finger and BTB domain containing 16. (679 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
CBLBCbl proto-oncogene B. (1182 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
CD83CD83 molecule. (391 aa)
HLXH2.0 like homeobox. (569 aa)
CARD11Caspase recruitment domain family member 11. (1163 aa)
PRDM1PR/SET domain 1. (821 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
LOC101088701Ig-like domain-containing protein. (370 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
FOXP3Forkhead box P3. (501 aa)
GATA3GATA binding protein 3. (444 aa)
CBFBUncharacterized protein. (187 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
SHBSH2 domain-containing protein. (508 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
LOC101100430Galectin. (138 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (703 aa)
NDFIP1Nedd4 family interacting protein 1. (224 aa)
NFKBIZNFKB inhibitor zeta. (956 aa)
LOC101083890Ig-like domain-containing protein. (285 aa)
PRKCZProtein kinase C zeta. (649 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
CD160CD160 molecule. (221 aa)
ADAAdenosine deaminase. (431 aa)
HMGB1Uncharacterized protein. (233 aa)
ENSFCAP00000060822Ig-like domain-containing protein. (252 aa)
ANXA1Annexin. (407 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
CCL19C-C motif chemokine. (115 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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