STRINGSTRING
MYB MYB SASH3 SASH3 CD81 CD81 IFNG IFNG TYK2 TYK2 IL12A IL12A GLI3 GLI3 IL23A IL23A MALT1 MALT1 SYK SYK SOCS5 SOCS5 CD28 CD28 RASAL3 RASAL3 RIPK2 RIPK2 ZBTB7B ZBTB7B IHH IHH ITPKB ITPKB ZBTB16 ZBTB16 NLRP3 NLRP3 LOC101082108 LOC101082108 IL12B IL12B IL18 IL18 CD83 CD83 HLX HLX CARD11 CARD11 PRKCQ PRKCQ NCKAP1L NCKAP1L FOXP3 FOXP3 CBFB CBFB SHB SHB SOCS1 SOCS1 LOC101081130 LOC101081130 IL2RG IL2RG NFKBIZ NFKBIZ PRKCZ PRKCZ PTPRC PTPRC ADA ADA ANXA1 ANXA1 SHH SHH CCL19 CCL19 PTPN22 PTPN22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYBMYB proto-oncogene, transcription factor. (761 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
CD81Tetraspanin. (236 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GLI3GLI family zinc finger 3. (1578 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
MALT1MALT1 paracaspase. (848 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
RASAL3RAS protein activator like 3. (1012 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ZBTB7BUncharacterized protein. (540 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa)
ZBTB16Zinc finger and BTB domain containing 16. (679 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
CD83CD83 molecule. (391 aa)
HLXH2.0 like homeobox. (569 aa)
CARD11Caspase recruitment domain family member 11. (1163 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
FOXP3Forkhead box P3. (501 aa)
CBFBUncharacterized protein. (187 aa)
SHBSH2 domain-containing protein. (508 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
NFKBIZNFKB inhibitor zeta. (956 aa)
PRKCZProtein kinase C zeta. (649 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
ADAAdenosine deaminase. (431 aa)
ANXA1Annexin. (407 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
CCL19C-C motif chemokine. (115 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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