85 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	GATA5	GATA binding protein 5. (398 aa)
	CLMP	CXADR like membrane protein. (373 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	SOX10	SRY-box transcription factor 10. (604 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (494 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	NIPBL	Nipped-B protein. (2805 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (180 aa)
	ALX4	ALX homeobox 4. (410 aa)
	FOXF2	Forkhead box F2. (449 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (342 aa)
	CCDC40	Coiled-coil domain containing 40. (1152 aa)
	EPHB3	EPH receptor B3. (1000 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	IL6ST	Interleukin 6 signal transducer. (918 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (641 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	CHD8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	GATA4	GATA binding protein 4. (443 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (487 aa)
	CCDC103	Coiled-coil domain containing 103. (249 aa)
	SALL1	Spalt like transcription factor 1. (1238 aa)
	FOXF1	Forkhead box F1. (459 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	NOTCH1	Notch receptor 1. (2543 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	TCF21	Transcription factor 21. (179 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KLF5	Kruppel like factor 5. (457 aa)
	GATA6	GATA binding protein 6. (646 aa)
	RB1	RB transcriptional corepressor 1. (930 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NKX2-6	NK2 homeobox 6. (299 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (282 aa)
	HLX	H2.0 like homeobox. (569 aa)
	SAV1	Salvador family WW domain containing protein 1. (395 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	SMAD3	Mothers against decapentaplegic homolog. (457 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	NKX3-2	NK3 homeobox 2. (379 aa)
	YIPF6	Protein YIPF. (236 aa)
	STRA6	Stimulated by retinoic acid 6. (700 aa)
	AHI1	Abelson helper integration site 1. (951 aa)
	COBL	Cordon-bleu WH2 repeat protein. (395 aa)
	PRDM1	PR/SET domain 1. (821 aa)
	SFRP2	Secreted frizzled related protein 2. (385 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	SRC	Tyrosine-protein kinase. (678 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa)
	PERCC1	Uncharacterized protein. (254 aa)
	MEGF8	Multiple EGF like domains 8. (2789 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	CCKBR	Cholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (454 aa)
	NKX2-3	NK2 homeobox 3. (368 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (692 aa)
	C1GALT1	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (367 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1857 aa)
	SOX9	SRY-box transcription factor 9. (511 aa)
	NPHP3	TPR_REGION domain-containing protein. (1348 aa)
	MYOCD	Myocardin. (962 aa)
	HOXA5	Homeobox A5. (381 aa)
	YAP1	Yes associated protein 1. (498 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (428 aa)
	LOC105261090	Protein YIPF. (246 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	RARRES2	Retinoic acid receptor responder 2. (451 aa)
	ZIC3	Zic family member 3. (553 aa)
	AHI1-2	Uncharacterized protein. (55 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (246 aa)
	ADA	Adenosine deaminase. (431 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4299 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
	FOXL1	Forkhead box L1. (364 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	SPDEF	ENSFCAP00000005031	ENSFCAP00000014240	Anterior gradient 2, protein disulphide isomerase family member.	SAM pointed domain containing ETS transcription factor.	0.576
AHI1	NPHP3	ENSFCAP00000038124	ENSFCAP00000046549	Abelson helper integration site 1.	TPR_REGION domain-containing protein.	0.525
AHI1-2	NPHP3	ENSFCAP00000056012	ENSFCAP00000046549	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.525
ALX4	GLI3	ENSFCAP00000005218	ENSFCAP00000011124	ALX homeobox 4.	GLI family zinc finger 3.	0.529
ASCL1	HES1	ENSFCAP00000057051	ENSFCAP00000051323	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.502
ASCL1	SHH	ENSFCAP00000057051	ENSFCAP00000061011	Achaete-scute family bHLH transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.453
ASCL1	SOX10	ENSFCAP00000057051	ENSFCAP00000002581	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 10.	0.741
ASCL1	SOX9	ENSFCAP00000057051	ENSFCAP00000045943	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 9.	0.616
BMP4	FGF10	ENSFCAP00000051185	ENSFCAP00000032796	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
BMP4	FGF9	ENSFCAP00000051185	ENSFCAP00000022386	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.625
BMP4	FOXF1	ENSFCAP00000051185	ENSFCAP00000017422	Bone morphogenetic protein 4.	Forkhead box F1.	0.481
BMP4	GATA4	ENSFCAP00000051185	ENSFCAP00000013945	Bone morphogenetic protein 4.	GATA binding protein 4.	0.674
BMP4	GATA5	ENSFCAP00000051185	ENSFCAP00000000983	Bone morphogenetic protein 4.	GATA binding protein 5.	0.424
BMP4	GATA6	ENSFCAP00000051185	ENSFCAP00000023729	Bone morphogenetic protein 4.	GATA binding protein 6.	0.614
BMP4	IHH	ENSFCAP00000051185	ENSFCAP00000017498	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.585
BMP4	NOTCH1	ENSFCAP00000051185	ENSFCAP00000020019	Bone morphogenetic protein 4.	Notch receptor 1.	0.410
BMP4	PDGFRA	ENSFCAP00000051185	ENSFCAP00000008478	Bone morphogenetic protein 4.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.562
BMP4	SHH	ENSFCAP00000051185	ENSFCAP00000061011	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.783
BMP4	SMAD3	ENSFCAP00000051185	ENSFCAP00000034334	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.702
BMP4	SOX10	ENSFCAP00000051185	ENSFCAP00000002581	Bone morphogenetic protein 4.	SRY-box transcription factor 10.	0.453