STRINGSTRING
PLAG1 PLAG1 TRIM28 TRIM28 PLXNA3 PLXNA3 EHMT2 EHMT2 WDTC1 WDTC1 SHH SHH STK3 STK3 SMPD3 SMPD3 ANXA1 ANXA1 CPNE1 CPNE1 ETNK2 ETNK2 SMO SMO DLL1 DLL1 TBCE TBCE GAS1 GAS1 SCAPER SCAPER ARIH2 ARIH2 ENSFCAP00000057272 ENSFCAP00000057272 ANXA6 ANXA6 FLRT3 FLRT3 IFRD2 IFRD2 PRKCZ PRKCZ NDEL1 NDEL1 CPLX1 CPLX1 COMP COMP ANKRD26 ANKRD26 RASAL2 RASAL2 JARID2 JARID2 PPP1R13L PPP1R13L SLC1A2 SLC1A2 SHBG SHBG CYFIP2 CYFIP2 NBN NBN FGF1 FGF1 MYMK MYMK BMP4 BMP4 KPNA1 KPNA1 RARG RARG PTX3 PTX3 CER1 CER1 SP2 SP2 AKIRIN1 AKIRIN1 SLC12A5 SLC12A5 MYMX MYMX LOC101093046 LOC101093046 YAP1 YAP1 BDNF BDNF HOXA5 HOXA5 PRKAR1A PRKAR1A UNC79 UNC79 EMX1 EMX1 SEMA5B SEMA5B LGR6 LGR6 NRP2 NRP2 TAF8 TAF8 ATF5 ATF5 AUTS2 AUTS2 BIN3 BIN3 GJE1 GJE1 TNKS2 TNKS2 RBBP6 RBBP6 GALK1 GALK1 RC3H2 RC3H2 SOX9 SOX9 LOC101092676 LOC101092676 TP53 TP53 TENM4 TENM4 HDAC6 HDAC6 RAPH1 RAPH1 SLC25A25 SLC25A25 MED1 MED1 GATA3 GATA3 ANKRD12 ANKRD12 EXT1 EXT1 CLIC4 CLIC4 APBA1 APBA1 ARID2 ARID2 ERBB4 ERBB4 TM4SF4 TM4SF4 EFNA5 EFNA5 WNT10B WNT10B EN1 EN1 ARX ARX MED12 MED12 ERCC1 ERCC1 RAD51B RAD51B EDNRA EDNRA SEMA5A SEMA5A SLIT2 SLIT2 SFRP2 SFRP2 LEPR LEPR HELT HELT LHX1 LHX1 BMPR1B BMPR1B CD9 CD9 LRP4 LRP4 RAG2 RAG2 COBL COBL DCLK1 DCLK1 TEC TEC HOXA11 HOXA11 PYGO2 PYGO2 PELO PELO TBX5 TBX5 TNN TNN WWTR1 WWTR1 STRA6 STRA6 SALL4 SALL4 BNC2 BNC2 SFRP1 SFRP1 IQGAP1 IQGAP1 DDR2 DDR2 LIMK1 LIMK1 SMAD3 SMAD3 STK40 STK40 LEP LEP FGF10 FGF10 IL7 IL7 TGFB2 TGFB2 SAV1 SAV1 HLX HLX ITGB1 ITGB1 MEX3C MEX3C SMAD4 SMAD4 GAS2 GAS2 ALKBH1 ALKBH1 KIF26B KIF26B PTPN11 PTPN11 PAK6 PAK6 ACVR1C ACVR1C MST1 MST1 IST1 IST1 CHST11 CHST11 WNT2 WNT2 FZD7 FZD7 SPART SPART LOC101092829 LOC101092829 ENSFCAP00000026835 ENSFCAP00000026835 USP9X USP9X GAP43 GAP43 LZTS2 LZTS2 NDN NDN ATM ATM BMP10 BMP10 G6PC G6PC NIN NIN CDKL3 CDKL3 IMPACT IMPACT HOXD13 HOXD13 ERCC6 ERCC6 JADE2 JADE2 ADD1 ADD1 VCL VCL BMPR1A BMPR1A ZFP36L1 ZFP36L1 GATA6 GATA6 UBE3A UBE3A TNFAIP6 TNFAIP6 ATN1 ATN1 KLF5 KLF5 ASPM ASPM MUSTN1 MUSTN1 PRKAR1B PRKAR1B APOD APOD GPR149 GPR149 NRN1 NRN1 ATF2 ATF2 FOXO3 FOXO3 FXN FXN SOS1 SOS1 PTN PTN FGF9 FGF9 HESX1 HESX1 SBDS SBDS WDR48 WDR48 OSTN OSTN SSNA1 SSNA1 LOC101082908 LOC101082908 TMEM108 TMEM108 DIPK2A DIPK2A NRN1L NRN1L MTM1 MTM1 CDKN1A CDKN1A ESR1 ESR1 LLPH LLPH WNT11 WNT11 H3F3A H3F3A TMEM182 TMEM182 NOTCH1 NOTCH1 SRF SRF BRCA2 BRCA2 STK4 STK4 MATN1 MATN1 FGF7 FGF7 TMEM38B TMEM38B RDH10 RDH10 KDF1 KDF1 ATRX ATRX IHH IHH ECM1 ECM1 CPQ CPQ WASF1 WASF1 MSTN MSTN PTEN PTEN TAF10 TAF10 NINJ1 NINJ1 CHEK1 CHEK1 HEG1 HEG1 RMI1 RMI1 EDN1 EDN1 COL3A1 COL3A1 TNR TNR TXK TXK ADPRHL1 ADPRHL1 EDN2 EDN2 STK11 STK11 SPRY1 SPRY1 CYFIP1 CYFIP1 KDM5B KDM5B GINS4 GINS4 SELENON SELENON FZD9 FZD9 RTF1 RTF1 NPPC NPPC GDF9 GDF9 PATL2 PATL2 GLI3 GLI3 DMBX1 DMBX1 ZPR1 ZPR1 CCM2 CCM2 ZMIZ1 ZMIZ1 TTC8 TTC8 SLIT3 SLIT3 ULK1 ULK1 CSF1 CSF1 DDR1 DDR1 RARB RARB LAMB2 LAMB2 PTK7 PTK7 NOTCH2 NOTCH2 SOX15 SOX15 KDM6A KDM6A NCAPG2 NCAPG2 TBX2 TBX2 MESP1 MESP1 NINJ2 NINJ2 LPAR3 LPAR3 EZH2 EZH2 SEMA7A SEMA7A TARBP2 TARBP2 SPRY2 SPRY2 INTS1 INTS1 DVL1 DVL1 SPTBN2 SPTBN2 ALCAM ALCAM SEMA3F SEMA3F CD81 CD81 LHX2 LHX2 XRCC2 XRCC2 THBS3 THBS3 HDGFL2 HDGFL2 ZMPSTE24 ZMPSTE24 CHRND CHRND SPAG6 SPAG6 MAP1B MAP1B IFT80 IFT80 EP300 EP300 MYOD1 MYOD1 CCDC151 CCDC151 DCX DCX SGCA SGCA SLC4A10 SLC4A10 ENSFCAP00000003985 ENSFCAP00000003985 SMAD1 SMAD1 EVC EVC NIPBL NIPBL CTNNB1 CTNNB1 PKDCC PKDCC POU4F2 POU4F2 RYK RYK SOX10 SOX10 SLIT1 SLIT1 ERCC2 ERCC2 SLITRK1 SLITRK1 KAT2A KAT2A PTGFRN PTGFRN CD4H9orf72 CD4H9orf72 CTC1 CTC1 APP APP SELENOM SELENOM FSHR FSHR CHCHD6 CHCHD6 CTR9 CTR9 AREG AREG TNS2 TNS2 FLVCR1 FLVCR1 MMP13 MMP13 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLAG1PLAG1 zinc finger. (499 aa)
TRIM28Tripartite motif containing 28. (821 aa)
PLXNA3Plexin A3. (1872 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1407 aa)
WDTC1WD and tetratricopeptide repeats 1. (700 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
STK3Serine/threonine kinase 3. (573 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (674 aa)
ANXA1Annexin. (407 aa)
CPNE1Copine 1. (542 aa)
ETNK2Ethanolamine kinase 2. (425 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
TBCEUncharacterized protein. (547 aa)
GAS1Growth arrest specific 1. (369 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1401 aa)
ARIH2RBR-type E3 ubiquitin transferase. (501 aa)
ENSFCAP00000057272Uncharacterized protein. (2518 aa)
ANXA6Annexin. (723 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
IFRD2Interferon related developmental regulator 2. (495 aa)
PRKCZProtein kinase C zeta. (649 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (480 aa)
CPLX1Complexin 1. (178 aa)
COMPCartilage oligomeric matrix protein. (804 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
RASAL2RAS protein activator like 2. (1459 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1251 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (867 aa)
SLC1A2Amino acid transporter. (579 aa)
SHBGSex hormone binding globulin. (400 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1335 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (564 aa)
RARGRetinoic acid receptor gamma. (459 aa)
PTX3Pentraxin 3. (381 aa)
CER1Cerberus 1, DAN family BMP antagonist. (270 aa)
SP2Sp2 transcription factor. (640 aa)
AKIRIN1Akirin 1. (192 aa)
SLC12A5Solute carrier family 12 member 5. (1196 aa)
MYMXMyomixer, myoblast fusion factor. (84 aa)
LOC101093046Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (208 aa)
YAP1Yes associated protein 1. (498 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
HOXA5Homeobox A5. (381 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
UNC79Unc-79 homolog, NALCN channel complex subunit. (2656 aa)
EMX1Empty spiracles homeobox 1. (296 aa)
SEMA5BSemaphorin 5B. (1100 aa)
LGR6LRRNT domain-containing protein. (967 aa)
NRP2Neuropilin 2. (992 aa)
TAF8TATA-box binding protein associated factor 8. (410 aa)
ATF5Activating transcription factor 5. (280 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1258 aa)
BIN3Bridging integrator 3. (352 aa)
GJE1Gap junction protein epsilon 1. (205 aa)
TNKS2Poly [ADP-ribose] polymerase. (1344 aa)
RBBP6RB binding protein 6, ubiquitin ligase. (1792 aa)
GALK1Galactokinase 1. (619 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
SOX9SRY-box transcription factor 9. (511 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
TENM4Teneurin transmembrane protein 4. (2823 aa)
HDAC6Histone deacetylase 6. (1178 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (650 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (513 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
GATA3GATA binding protein 3. (444 aa)
ANKRD12Ankyrin repeat domain 12. (2060 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (831 aa)
ARID2AT-rich interaction domain 2. (1874 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
TM4SF4Transmembrane 4 L six family member 4. (202 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
EN1Homeobox protein engrailed-like. (396 aa)
ARXAristaless related homeobox. (562 aa)
MED12Mediator complex subunit 12. (2278 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (329 aa)
RAD51BRAD51 paralog B. (350 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA5ASemaphorin 5A. (1116 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
LEPRLeptin receptor. (1166 aa)
HELTHelt bHLH transcription factor. (242 aa)
LHX1LIM homeobox 1. (406 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
CD9CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (250 aa)
LRP4LDL receptor related protein 4. (1905 aa)
RAG2Recombination activating 2. (527 aa)
COBLCordon-bleu WH2 repeat protein. (395 aa)
DCLK1Doublecortin like kinase 1. (741 aa)
TECTyrosine-protein kinase. (650 aa)
HOXA11Homeobox A11. (327 aa)
PYGO2Pygopus family PHD finger 2. (406 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
TBX5T-box transcription factor 5. (518 aa)
TNNTenascin N. (1120 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
STRA6Stimulated by retinoic acid 6. (700 aa)
SALL4Spalt like transcription factor 4. (1058 aa)
BNC2Basonuclin 2. (1115 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
LIMK1LIM domain kinase 1. (763 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
STK40Serine/threonine kinase 40. (491 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
IL7Interleukin 7. (158 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SAV1Salvador family WW domain containing protein 1. (395 aa)
HLXH2.0 like homeobox. (569 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
MEX3CMex-3 RNA binding family member C. (657 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GAS2Growth arrest specific 2. (314 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (352 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1970 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
CHST11Carbohydrate sulfotransferase. (395 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SPARTSpartin. (672 aa)
LOC101092829Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (165 aa)
ENSFCAP00000026835Uncharacterized protein. (73 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (242 aa)
LZTS2Leucine zipper tumor suppressor 2. (645 aa)
NDNNecdin, MAGE family member. (324 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
NINNinein. (2128 aa)
CDKL3Cyclin dependent kinase like 3. (581 aa)
IMPACTImpact RWD domain protein. (331 aa)
HOXD13Homeobox D13. (341 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
JADE2Jade family PHD finger 2. (827 aa)
ADD1Adducin 1. (761 aa)
VCLVinculin. (1066 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
GATA6GATA binding protein 6. (646 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (834 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
ATN1Atrophin 1. (1193 aa)
KLF5Kruppel like factor 5. (457 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
MUSTN1Uncharacterized protein. (86 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
APODApolipoprotein D. (189 aa)
GPR149G protein-coupled receptor 149. (747 aa)
NRN1Neuritin 1. (142 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
FOXO3Forkhead box O3. (672 aa)
FXNFrataxin. (211 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PTNPleiotrophin. (179 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HESX1HESX homeobox 1. (207 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
WDR48WD repeat domain 48. (677 aa)
OSTNOsteocrin. (132 aa)
SSNA1SS nuclear autoantigen 1. (119 aa)
LOC101082908Uncharacterized protein. (591 aa)
TMEM108Transmembrane protein 108. (581 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
NRN1LNeuritin 1 like. (169 aa)
MTM1Myotubularin 1. (603 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (127 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
TMEM182Transmembrane protein 182. (229 aa)
NOTCH1Notch receptor 1. (2543 aa)
SRFSerum response factor. (512 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
STK4Serine/threonine kinase 4. (487 aa)
MATN1Matrilin 1. (539 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TMEM38BTransmembrane protein 38B. (409 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
ATRXATRX chromatin remodeler. (2486 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ECM1Extracellular matrix protein 1. (562 aa)
CPQCarboxypeptidase Q. (472 aa)
WASF1WASP family member 1. (570 aa)
MSTNMyostatin. (375 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
NINJ1Ninjurin 1. (151 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
HEG1Heart development protein with EGF like domains 1. (1374 aa)
RMI1RecQ mediated genome instability 1. (635 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
TNRTenascin R. (1358 aa)
TXKTyrosine-protein kinase. (551 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
SPRY1Sprouty RTK signaling antagonist 1. (362 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
KDM5BLysine demethylase 5B. (1544 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (232 aa)
SELENONSelenoprotein N. (556 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
NPPCNatriuretic peptide C. (193 aa)
GDF9Growth differentiation factor 9. (452 aa)
PATL2SPG11 vesicle trafficking associated, spatacsin. (2444 aa)
GLI3GLI family zinc finger 3. (1578 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (374 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CCM2CCM2 scaffold protein. (453 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (921 aa)
RARBRetinoic acid receptor beta. (448 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
NOTCH2Notch receptor 2. (2493 aa)
SOX15SRY-box 15. (233 aa)
KDM6ALysine demethylase 6A. (1453 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1139 aa)
TBX2T-box transcription factor 2. (713 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (261 aa)
NINJ2Ninjurin 2. (190 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (383 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (769 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
INTS1Integrator complex subunit 1. (2186 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2418 aa)
ALCAMActivated leukocyte cell adhesion molecule. (583 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
CD81Tetraspanin. (236 aa)
LHX2LIM homeobox 2. (406 aa)
XRCC2X-ray repair cross complementing 2. (276 aa)
THBS3Thrombospondin 3. (955 aa)
HDGFL2HDGF like 2. (671 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (517 aa)
SPAG6Sperm associated antigen 6. (509 aa)
MAP1BMicrotubule associated protein 1B. (2471 aa)
IFT80Intraflagellar transport 80. (777 aa)
EP300E1A binding protein p300. (2425 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
CCDC151Coiled-coil domain containing 151. (595 aa)
DCXDoublecortin. (365 aa)
SGCASarcoglycan alpha. (439 aa)
SLC4A10Anion exchange protein. (1118 aa)
ENSFCAP00000003985Uncharacterized protein. (184 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EVCEvC ciliary complex subunit 1. (943 aa)
NIPBLNipped-B protein. (2805 aa)
CTNNB1Catenin beta 1. (783 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (494 aa)
POU4F2POU domain protein. (408 aa)
RYKReceptor like tyrosine kinase. (609 aa)
SOX10SRY-box transcription factor 10. (604 aa)
SLIT1Slit guidance ligand 1. (1518 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
PTGFRNProstaglandin F2 receptor inhibitor. (995 aa)
CD4H9orf72Chromosome D4 C9orf72 homolog. (481 aa)
CTC1CST telomere replication complex component 1. (1218 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
SELENOMSelenoprotein M. (141 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (2112 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
AREGAmphiregulin. (323 aa)
TNS2Tensin 2. (1409 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1; Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies (By similari [...] (560 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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