STRINGSTRING
ENG ENG TBX20 TBX20 MYBPC3 MYBPC3 CHD7 CHD7 LRP2 LRP2 MYH6 MYH6 COL3A1 COL3A1 HAND1 HAND1 MYF5 MYF5 HEG1 HEG1 TNNC1 TNNC1 ANKRD1 ANKRD1 PROX1 PROX1 SMTNL1 SMTNL1 NOTCH1 NOTCH1 DLL4 DLL4 FOXH1 FOXH1 FZD2 FZD2 PKP2 PKP2 BMPR1A BMPR1A BMP10 BMP10 MYL10 MYL10 WNT2 WNT2 BMP2 BMP2 SMAD4 SMAD4 LIF LIF TCAP TCAP EDNRA EDNRA SMAD7 SMAD7 MED1 MED1 ZFPM2 ZFPM2 LOC101092676 LOC101092676 NOG NOG XIRP2 XIRP2 TGFBR1 TGFBR1 GSC GSC ZFPM1 ZFPM1 CNTF CNTF MYLK2 MYLK2 RYR2 RYR2 PTCD2 PTCD2 MYL2 MYL2 TNNI1 TNNI1 NKX2-5 NKX2-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin. (654 aa)
TBX20T-box transcription factor 20. (480 aa)
MYBPC3Myosin binding protein C, cardiac. (1273 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
LRP2LDL receptor related protein 2. (4646 aa)
MYH6Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
HEG1Heart development protein with EGF like domains 1. (1374 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
PROX1Prospero homeobox 1. (737 aa)
SMTNL1Smoothelin like 1. (478 aa)
NOTCH1Notch receptor 1. (2543 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
FOXH1Forkhead box H1. (361 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
PKP2Plakophilin 2. (1014 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
MYL10Myosin light chain 10. (167 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
TCAPTitin-cap. (143 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
XIRP2Xin actin binding repeat containing 2. (3521 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
GSCGoosecoid homeobox. (256 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MYLK2Myosin light chain kinase 2. (742 aa)
RYR2Ryanodine receptor 2. (4967 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
MYL2Myosin light chain 2. (174 aa)
TNNI1Troponin I1, slow skeletal type. (207 aa)
NKX2-5NK2 homeobox 5. (333 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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