| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | KRAS | ENSFCAP00000004739 | ENSFCAP00000016005 | Tyrosine-protein kinase. | Uncharacterized protein. | 0.428 |
| AGER | APP | ENSFCAP00000004183 | ENSFCAP00000001445 | Advanced glycosylation end-product specific receptor. | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.633 |
| AGER | KRAS | ENSFCAP00000004183 | ENSFCAP00000016005 | Advanced glycosylation end-product specific receptor. | Uncharacterized protein. | 0.918 |
| AGER | S100A9 | ENSFCAP00000004183 | ENSFCAP00000002948 | Advanced glycosylation end-product specific receptor. | Protein S100; Belongs to the S-100 family. | 0.520 |
| AGER | S100B | ENSFCAP00000004183 | ENSFCAP00000036720 | Advanced glycosylation end-product specific receptor. | Protein S100; Belongs to the S-100 family. | 0.954 |
| APP | AGER | ENSFCAP00000001445 | ENSFCAP00000004183 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Advanced glycosylation end-product specific receptor. | 0.633 |
| APP | GFAP | ENSFCAP00000001445 | ENSFCAP00000005071 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.654 |
| APP | IFNG | ENSFCAP00000001445 | ENSFCAP00000008355 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.437 |
| APP | PLP1 | ENSFCAP00000001445 | ENSFCAP00000033932 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Proteolipid protein 1. | 0.503 |
| APP | S100B | ENSFCAP00000001445 | ENSFCAP00000036720 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Protein S100; Belongs to the S-100 family. | 0.535 |
| APP | TLR4 | ENSFCAP00000001445 | ENSFCAP00000023731 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.517 |
| APP | TREM2 | ENSFCAP00000001445 | ENSFCAP00000002549 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Triggering receptor expressed on myeloid cells 2. | 0.627 |
| BMP2 | SOX9 | ENSFCAP00000031036 | ENSFCAP00000045943 | Bone morphogenetic protein 2. | SRY-box transcription factor 9. | 0.569 |
| C1QA | GFAP | ENSFCAP00000017199 | ENSFCAP00000005071 | Complement C1q A chain. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.648 |
| C1QA | TLR4 | ENSFCAP00000017199 | ENSFCAP00000023731 | Complement C1q A chain. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.490 |
| C1QA | TREM2 | ENSFCAP00000017199 | ENSFCAP00000002549 | Complement C1q A chain. | Triggering receptor expressed on myeloid cells 2. | 0.848 |
| C1QA | VIM | ENSFCAP00000017199 | ENSFCAP00000050131 | Complement C1q A chain. | Vimentin; Belongs to the intermediate filament family. | 0.421 |
| CNTF | GAP43 | ENSFCAP00000049944 | ENSFCAP00000026410 | Ciliary neurotrophic factor. | Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). | 0.499 |
| CNTF | GFAP | ENSFCAP00000049944 | ENSFCAP00000005071 | Ciliary neurotrophic factor. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.648 |
| CNTF | SMO | ENSFCAP00000049944 | ENSFCAP00000059936 | Ciliary neurotrophic factor. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.637 |