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S100A8 S100A8 GPR37L1 GPR37L1 APP APP STAT3 STAT3 NR2E1 NR2E1 TREM2 TREM2 S100A9 S100A9 AGER AGER ABL1 ABL1 LAMC3 LAMC3 GFAP GFAP PAX6 PAX6 EIF2B5 EIF2B5 IFNG IFNG LAMB2 LAMB2 KRAS KRAS C1QA C1QA TSPAN2 TSPAN2 TLR4 TLR4 MAPK1 MAPK1 GAP43 GAP43 CUL4B CUL4B PTPN11 PTPN11 BMP2 BMP2 PLP1 PLP1 MAPK3 MAPK3 S100B S100B VAX1 VAX1 SOX8 SOX8 GCM1 GCM1 HES5 HES5 C5AR1 C5AR1 SOX9 SOX9 CNTF CNTF VIM VIM TAL1 TAL1 NF1 NF1 TTC21B TTC21B DLL1 DLL1 SMO SMO PLPP3 PLPP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
S100A8Protein S100; Belongs to the S-100 family. (124 aa)
GPR37L1G protein-coupled receptor 37 like 1. (551 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
S100A9Protein S100; Belongs to the S-100 family. (135 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
PAX6Paired box 6. (437 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
KRASUncharacterized protein. (380 aa)
C1QAComplement C1q A chain. (245 aa)
TSPAN2Tetraspanin. (221 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (242 aa)
CUL4BCullin 4B; Belongs to the cullin family. (911 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PLP1Proteolipid protein 1. (307 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
VAX1Ventral anterior homeobox 1. (372 aa)
SOX8SRY-box 8. (883 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SOX9SRY-box transcription factor 9. (511 aa)
CNTFCiliary neurotrophic factor. (200 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (414 aa)
NF1Neurofibromin 1. (2856 aa)
TTC21BTetratricopeptide repeat domain 21B. (1325 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
PLPP3acidPPc domain-containing protein. (324 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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