74 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	ELF3	E74 like ETS transcription factor 3. (370 aa)
	CRB1	Crumbs cell polarity complex component 1. (1405 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (576 aa)
	RAB3D	RAB3D, member RAS oncogene family. (219 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2995 aa)
	THBS4	Thrombospondin 4. (964 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (244 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	BSX	Brain specific homeobox. (232 aa)
	HTR1B	5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
	TIMP1	TIMP metallopeptidase inhibitor 1. (305 aa)
	RSPO3	R-spondin 3. (279 aa)
	HNF1A	HNF1 homeobox A. (639 aa)
	NOTCH2	Notch receptor 2. (2493 aa)
	EPHA2	EPH receptor A2. (936 aa)
	IL23A	Interleukin 23 subunit alpha. (196 aa)
	EPAS1	Endothelial PAS domain protein 1. (872 aa)
	NCDN	Neurochondrin. (732 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1137 aa)
	TPP1	Tripeptidyl peptidase 1. (562 aa)
	CCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (749 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
	IAPP	Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. (89 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (806 aa)
	VDR	Vitamin D receptor. (441 aa)
	TPH1	Tryptophan hydroxylase 1. (527 aa)
	PTN	Pleiotrophin. (179 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
	GPR55	G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	CCDC154	Coiled-coil domain containing 154. (524 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (590 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	MEF2C	MADS-box domain-containing protein. (483 aa)
	IL7	Interleukin 7. (158 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	LIF	LIF interleukin 6 family cytokine. (204 aa)
	AXL	AXL receptor tyrosine kinase. (861 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
	LIPA	Lipase A, lysosomal acid type. (491 aa)
	MITF	Melanocyte inducing transcription factor. (502 aa)
	FLNA	Filamin A. (2808 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (954 aa)
	LOC111559084	Peptidase S53 domain-containing protein. (572 aa)
	LRRK1	Leucine rich repeat kinase 1. (2188 aa)
	ACP5	Tartrate-resistant acid phosphatase type 5. (325 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SRC	Tyrosine-protein kinase. (678 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	HOXA3	Homeobox A3. (441 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (263 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1302 aa)
	SNX10	Sorting nexin 10. (201 aa)
	RASSF2	Ras association domain family member 2. (375 aa)
	SPP2	Secreted phosphoprotein 2. (243 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (633 aa)
	BAK1	BCL2 antagonist/killer 1. (251 aa)
	NOL3	Nucleolar protein 3. (218 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP5	TNFSF11	ENSFCAP00000040238	ENSFCAP00000005491	Tartrate-resistant acid phosphatase type 5.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.436
ACVRL1	BMPR2	ENSFCAP00000037629	ENSFCAP00000013072	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.962
ACVRL1	EPAS1	ENSFCAP00000037629	ENSFCAP00000012637	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endothelial PAS domain protein 1.	0.403
ACVRL1	TGFB1	ENSFCAP00000037629	ENSFCAP00000005040	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.701
ACVRL1	TGFB3	ENSFCAP00000037629	ENSFCAP00000013178	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.951
ATG5	CAV1	ENSFCAP00000046882	ENSFCAP00000029296	Autophagy protein 5; Involved in autophagic vesicle formation.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.463
ATG5	HIF1A	ENSFCAP00000046882	ENSFCAP00000003163	Autophagy protein 5; Involved in autophagic vesicle formation.	Hypoxia inducible factor 1 subunit alpha.	0.459
AXL	EPHA2	ENSFCAP00000035876	ENSFCAP00000009443	AXL receptor tyrosine kinase.	EPH receptor A2.	0.443
AXL	FLNA	ENSFCAP00000035876	ENSFCAP00000039439	AXL receptor tyrosine kinase.	Filamin A.	0.403
AXL	SRC	ENSFCAP00000035876	ENSFCAP00000041142	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.963
AXL	TRAF6	ENSFCAP00000035876	ENSFCAP00000047805	AXL receptor tyrosine kinase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.569
BMPR2	ACVRL1	ENSFCAP00000013072	ENSFCAP00000037629	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.962
BMPR2	CAV1	ENSFCAP00000013072	ENSFCAP00000029296	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.402
BMPR2	TGFB1	ENSFCAP00000013072	ENSFCAP00000005040	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.603
BMPR2	TGFB3	ENSFCAP00000013072	ENSFCAP00000013178	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.473
CAV1	ATG5	ENSFCAP00000029296	ENSFCAP00000046882	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.463
CAV1	BMPR2	ENSFCAP00000029296	ENSFCAP00000013072	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.402
CAV1	EPHA2	ENSFCAP00000029296	ENSFCAP00000009443	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	EPH receptor A2.	0.484
CAV1	FLNA	ENSFCAP00000029296	ENSFCAP00000039439	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Filamin A.	0.634
CAV1	HIF1A	ENSFCAP00000029296	ENSFCAP00000003163	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Hypoxia inducible factor 1 subunit alpha.	0.401