STRINGSTRING
ENG ENG CHD7 CHD7 HPGD HPGD LRP2 LRP2 TBX2 TBX2 ANGPTL3 ANGPTL3 ZMIZ1 ZMIZ1 TFAP2E TFAP2E BMPR2 BMPR2 DLL4 DLL4 COL3A1 COL3A1 EDN1 EDN1 TFAP2B TFAP2B PROX1 PROX1 FOXF1 FOXF1 SRF SRF NOTCH1 NOTCH1 WNT11 WNT11 FOXH1 FOXH1 NPRL3 NPRL3 CITED2 CITED2 APOB APOB BMPR1A BMPR1A PKD2 PKD2 STRA6 STRA6 ACVRL1 ACVRL1 PRDM1 PRDM1 EDNRA EDNRA ARID2 ARID2 SMAD7 SMAD7 HAND2 HAND2 NOG NOG FKBP10 FKBP10 JAG1 JAG1 NF1 NF1 COMP COMP ADGRF5 ADGRF5 HOXA13 HOXA13 HES1 HES1 BMP4 BMP4 LDLR LDLR MYOCD MYOCD TGFBR1 TGFBR1 SEC24B SEC24B EYA1 EYA1 GJA5 GJA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin. (654 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
LRP2LDL receptor related protein 2. (4646 aa)
TBX2T-box transcription factor 2. (713 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
TFAP2ETranscription factor AP-2 epsilon. (441 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
PROX1Prospero homeobox 1. (737 aa)
FOXF1Forkhead box F1. (459 aa)
SRFSerum response factor. (512 aa)
NOTCH1Notch receptor 1. (2543 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FOXH1Forkhead box H1. (361 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
APOBApolipoprotein B. (4441 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
STRA6Stimulated by retinoic acid 6. (700 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
PRDM1PR/SET domain 1. (821 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ARID2AT-rich interaction domain 2. (1874 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
HAND2Heart and neural crest derivatives expressed 2. (275 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FKBP10Peptidylprolyl isomerase. (628 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
NF1Neurofibromin 1. (2856 aa)
COMPCartilage oligomeric matrix protein. (804 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1387 aa)
HOXA13Homeobox A13. (389 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LDLRLow density lipoprotein receptor. (866 aa)
MYOCDMyocardin. (962 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1259 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.