46 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENG	Endoglin. (654 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2995 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
	LRP2	LDL receptor related protein 2. (4646 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	ANGPTL3	Angiopoietin like 3. (460 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1066 aa)
	TFAP2E	Transcription factor AP-2 epsilon. (441 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	TFAP2B	Transcription factor AP-2 beta. (476 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	FOXF1	Forkhead box F1. (459 aa)
	SRF	Serum response factor. (512 aa)
	NOTCH1	Notch receptor 1. (2543 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FOXH1	Forkhead box H1. (361 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (569 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	APOB	Apolipoprotein B. (4441 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (970 aa)
	STRA6	Stimulated by retinoic acid 6. (700 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
	PRDM1	PR/SET domain 1. (821 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ARID2	AT-rich interaction domain 2. (1874 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (275 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FKBP10	Peptidylprolyl isomerase. (628 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
	NF1	Neurofibromin 1. (2856 aa)
	COMP	Cartilage oligomeric matrix protein. (804 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1387 aa)
	HOXA13	Homeobox A13. (389 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	LDLR	Low density lipoprotein receptor. (866 aa)
	MYOCD	Myocardin. (962 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1259 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP4	ENSFCAP00000037629	ENSFCAP00000051185	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.904
ACVRL1	BMPR1A	ENSFCAP00000037629	ENSFCAP00000024415	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.400
ACVRL1	BMPR2	ENSFCAP00000037629	ENSFCAP00000013072	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.962
ACVRL1	ENG	ENSFCAP00000037629	ENSFCAP00000001383	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.725
ACVRL1	SMAD7	ENSFCAP00000037629	ENSFCAP00000042878	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.724
ANGPTL3	APOB	ENSFCAP00000010482	ENSFCAP00000023369	Angiopoietin like 3.	Apolipoprotein B.	0.599
ANGPTL3	SEC24B	ENSFCAP00000010482	ENSFCAP00000000065	Angiopoietin like 3.	SEC24 homolog B, COPII coat complex component.	0.455
APOB	ANGPTL3	ENSFCAP00000023369	ENSFCAP00000010482	Apolipoprotein B.	Angiopoietin like 3.	0.599
APOB	LDLR	ENSFCAP00000023369	ENSFCAP00000050615	Apolipoprotein B.	Low density lipoprotein receptor.	0.975
APOB	LRP2	ENSFCAP00000023369	ENSFCAP00000005687	Apolipoprotein B.	LDL receptor related protein 2.	0.519
ARID2	NF1	ENSFCAP00000042737	ENSFCAP00000055600	AT-rich interaction domain 2.	Neurofibromin 1.	0.444
BMP4	ACVRL1	ENSFCAP00000051185	ENSFCAP00000037629	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.904
BMP4	BMPR1A	ENSFCAP00000051185	ENSFCAP00000024415	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.996
BMP4	BMPR2	ENSFCAP00000051185	ENSFCAP00000013072	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992
BMP4	EYA1	ENSFCAP00000051185	ENSFCAP00000000226	Bone morphogenetic protein 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.427
BMP4	FOXF1	ENSFCAP00000051185	ENSFCAP00000017422	Bone morphogenetic protein 4.	Forkhead box F1.	0.481
BMP4	HAND2	ENSFCAP00000051185	ENSFCAP00000043680	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.492
BMP4	JAG1	ENSFCAP00000051185	ENSFCAP00000058021	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.693
BMP4	NOG	ENSFCAP00000051185	ENSFCAP00000046242	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	NOTCH1	ENSFCAP00000051185	ENSFCAP00000020019	Bone morphogenetic protein 4.	Notch receptor 1.	0.410