Your Input: | |
| | ZGPAT | Uncharacterized protein. (802 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1308 aa) |
| | IL31RA | Interleukin 31 receptor A. (661 aa) |
| | SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1. (441 aa) |
| | TNFSF18 | TNF superfamily member 18. (178 aa) |
| | INPP5F | Inositol polyphosphate-5-phosphatase F. (1133 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (416 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1279 aa) |
| | ALKAL1 | Uncharacterized protein. (283 aa) |
| | GRM5 | Glutamate metabotropic receptor 5. (1208 aa) |
| | CLEC6A | C-type lectin domain containing 6A. (212 aa) |
| | SH3BP5L | SH3 binding domain protein 5 like. (393 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (735 aa) |
| | PDCL3 | Phosducin like 3. (240 aa) |
| | DMTN | Dematin actin binding protein. (405 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (203 aa) |
| | ALKAL2 | Uncharacterized protein. (60 aa) |
| | GFRA1 | GDNF family receptor alpha 1. (509 aa) |
| | CD44 | CD44 molecule (Indian blood group). (741 aa) |
| | CTF1 | Cardiotrophin 1. (237 aa) |
| | CNTF | Ciliary neurotrophic factor. (200 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1732 aa) |
| | VEGFA | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | TSG101 | Tumor susceptibility 101. (400 aa) |
| | FGFR1OP | FGFR1 oncogene partner. (732 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (764 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (263 aa) |
| | PDGFD | Platelet derived growth factor D. (380 aa) |
| | SH2D1B | SH2 domain-containing protein. (135 aa) |
| | DOK7 | Docking protein 7. (595 aa) |
| | ENSFCAP00000054025 | Uncharacterized protein. (329 aa) |
| | IL11 | Interleukin 11. (424 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (414 aa) |
| | PRKCZ | Protein kinase C zeta. (649 aa) |
| | ZFYVE28 | Zinc finger FYVE-type containing 28. (961 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1299 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa) |
| | RELN | Reelin. (3460 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (779 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | ENSFCAP00000058213 | Uncharacterized protein. (144 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (357 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (696 aa) |
| | SH3BP5 | SH3 domain binding protein 5. (451 aa) |
| | NCF1 | Neutrophil cytosolic factor 1. (390 aa) |
| | PLPP3 | acidPPc domain-containing protein. (324 aa) |
| | TGFA | Transforming growth factor alpha. (192 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (385 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (2188 aa) |
| | ENSFCAP00000039742 | ARL2_Bind_BART domain-containing protein. (125 aa) |
| | LRP4 | LDL receptor related protein 4. (1905 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (281 aa) |
| | GGNBP2 | Gametogenetin binding protein 2. (740 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (313 aa) |
| | CSF3 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. (204 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | OSM | Oncostatin M. (238 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | LIF | LIF interleukin 6 family cytokine. (204 aa) |
| | IGF2 | Insulin like growth factor 2. (280 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa) |
| | BTC | Betacellulin. (194 aa) |
| | ENSFCAP00000033605 | Uncharacterized protein. (147 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1181 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (784 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | IL7 | Interleukin 7. (158 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | VPS25 | Vacuolar protein sorting 25 homolog. (176 aa) |
| | PRNP | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa) |
| | ENSFCAP00000030321 | Uncharacterized protein. (79 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4. (441 aa) |
| | LOC101089242 | Uncharacterized protein. (2397 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | FAM72A | Uncharacterized protein. (149 aa) |
| | PTK6 | Tyrosine-protein kinase. (450 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | ENSFCAP00000028212 | Uncharacterized protein. (83 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (282 aa) |
| | CASS4 | Cas scaffold protein family member 4. (818 aa) |
| | SRCIN1 | SRC kinase signaling inhibitor 1. (1219 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (326 aa) |
| | CBLB | Cbl proto-oncogene B. (1182 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | CBLC | Cbl proto-oncogene C. (494 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A. (470 aa) |
| | NOX4 | NADPH oxidase 4. (578 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1484 aa) |
| | BMP6 | Bone morphogenetic protein 6. (502 aa) |
| | IL34 | Interleukin 34. (331 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | MVP | Major vault protein. (892 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | IBTK | Inhibitor of Bruton tyrosine kinase. (1311 aa) |
| | ANGPT4 | Angiopoietin 4. (499 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (547 aa) |
| | LOC101082108 | Ig-like domain-containing protein. (386 aa) |
| | LYN | Tyrosine-protein kinase. (526 aa) |
| | M3X652_FELCA | Uncharacterized protein. (164 aa) |
| | LOC101087936 | Uncharacterized protein. (373 aa) |
| | FYN | Tyrosine-protein kinase. (589 aa) |
| | M3WZR3_FELCA | ARL2_Bind_BART domain-containing protein. (163 aa) |
| | ABI1 | Abl interactor 1. (508 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (574 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | EREG | Epiregulin. (169 aa) |
| | CBL | Cbl proto-oncogene. (902 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (340 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (494 aa) |
| | ERBB3 | ERBB3. (1339 aa) |
| | SYK | Spleen associated tyrosine kinase. (636 aa) |
| | HRG | Histidine rich glycoprotein. (536 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | DGKQ | Diacylglycerol kinase. (942 aa) |
| | CSPG4 | Chondroitin sulfate proteoglycan 4. (2299 aa) |
| | IL23A | Interleukin 23 subunit alpha. (196 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | GATA1 | GATA binding protein 1. (413 aa) |
| | IL6ST | Interleukin 6 signal transducer. (918 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa) |
| | CRLF1 | Cytokine receptor like factor 1. (421 aa) |
| | TMEM102 | Transmembrane protein 102. (510 aa) |
| | CD80 | B-lymphocyte activation antigen B7-1 (CD80). (292 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1139 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | SRMS | Tyrosine-protein kinase. (507 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | VTN | SMB domain-containing protein. (468 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | CD81 | Tetraspanin. (236 aa) |
| | GAS6 | Growth arrest specific 6. (674 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (835 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (161 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (460 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa) |
| | NF2 | Neurofibromin 2. (596 aa) |
| | SEMA4D | Semaphorin 4D; Belongs to the semaphorin family. (863 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (427 aa) |
| | THBS4 | Thrombospondin 4. (964 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa) |
| | CSF1R | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa) |
| | LOC102899310 | Ig-like domain-containing protein. (320 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (246 aa) |
| | SH2B3 | SH2B adaptor protein 3. (578 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa) |
| | RACK1 | WD_REPEATS_REGION domain-containing protein. (424 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa) |
| | ZZEF1 | Zinc finger ZZ-type and EF-hand domain containing 1. (2956 aa) |
| | APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (305 aa) |
| | AFAP1L2 | Actin filament associated protein 1 like 2. (810 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (749 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (828 aa) |
| | AREG | Amphiregulin. (323 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (166 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | LOC101088701 | Ig-like domain-containing protein. (370 aa) |
| | LRP8 | LDL receptor related protein 8. (1015 aa) |
