STRINGSTRING
MTOR MTOR PLXND1 PLXND1 LOC101097531 LOC101097531 CHCHD6 CHCHD6 CDKL5 CDKL5 SNW1 SNW1 PLXNB1 PLXNB1 NR2E1 NR2E1 ANKRD27 ANKRD27 SLITRK1 SLITRK1 SERPINE2 SERPINE2 CX3CR1 CX3CR1 STK25 STK25 SOX10 SOX10 POU4F2 POU4F2 HIF1A HIF1A CTNNB1 CTNNB1 TNFRSF1B TNFRSF1B SEMA4D SEMA4D NUMBL NUMBL TGFB1 TGFB1 GFAP GFAP IL1B IL1B LRP2 LRP2 TIAM2 TIAM2 SERPINF1 SERPINF1 NPTN NPTN ELL3 ELL3 SRRT SRRT XRCC2 XRCC2 PAX6 PAX6 UFL1 UFL1 VEGFC VEGFC SEMA7A SEMA7A EGR2 EGR2 TRPV2 TRPV2 LPAR3 LPAR3 RNF112 RNF112 IFNG IFNG FN1 FN1 MAN2A1 MAN2A1 CUL7 CUL7 IL6ST IL6ST WNT3 WNT3 PLXNB2 PLXNB2 GLI3 GLI3 BRAF BRAF PRKCH PRKCH STK11 STK11 KDM1A KDM1A BMPR2 BMPR2 SS18L1 SS18L1 KRAS KRAS CLCF1 CLCF1 TRIM32 TRIM32 NEURL1 NEURL1 TWF2 TWF2 SRF SRF NOTCH1 NOTCH1 SHTN1 SHTN1 ISLR ISLR ASPA ASPA PKHD1L1 PKHD1L1 DBN1 DBN1 CAPRIN1 CAPRIN1 FZD3 FZD3 GSX2 GSX2 IL6 IL6 PTN PTN ASPM ASPM MAP6 MAP6 BHLHB9 BHLHB9 LIG4 LIG4 IL34 IL34 JADE2 JADE2 NKX6-1 NKX6-1 PRKCI PRKCI METRNL METRNL CDKL3 CDKL3 NIN NIN METRN METRN PAFAH1B1 PAFAH1B1 OPRM1 OPRM1 OLIG2 OLIG2 DISC1 DISC1 WNT2 WNT2 DCT DCT IST1 IST1 BMP2 BMP2 ISLR2 ISLR2 ITGB1 ITGB1 PLXNC1 PLXNC1 LIF LIF LIMK1 LIMK1 WNT3A WNT3A PLXNA2 PLXNA2 BIN1 BIN1 SOX8 SOX8 MARCKS MARCKS CAPRIN2 CAPRIN2 LRP8 LRP8 FAIM FAIM EFNA5 EFNA5 ZNF365 ZNF365 OBSL1 OBSL1 MEGF8 MEGF8 ZFYVE27 ZFYVE27 GPER1 GPER1 DMRTA2 DMRTA2 PLAG1 PLAG1 NGF NGF TENM4 TENM4 CHODL CHODL DHX36 DHX36 LAYN LAYN NEFL NEFL MECP2 MECP2 BDNF BDNF NKX6-2 NKX6-2 FOXG1 FOXG1 SMARCD3 SMARCD3 NUMB NUMB TNF TNF HES1 HES1 PLXNA4 PLXNA4 CUX2 CUX2 MAP3K13 MAP3K13 XRCC5 XRCC5 GOLGA4 GOLGA4 PLXNB3 PLXNB3 FBXW8 FBXW8 TGM2 TGM2 ENSFCAP00000056200 ENSFCAP00000056200 ASCL1 ASCL1 RELN RELN NTN1 NTN1 ZNF335 ZNF335 SPEN SPEN SMO SMO DBNL DBNL ZNF488 ZNF488 PLXNA3 PLXNA3 OTP OTP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PLXND1Plexin D1. (1927 aa)
LOC101097531Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (2112 aa)
CDKL5Cyclin dependent kinase like 5. (978 aa)
SNW1SNW domain containing 1. (570 aa)
PLXNB1Plexin B1. (2135 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
ANKRD27Ankyrin repeat domain 27. (1050 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (484 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
STK25Serine/threonine kinase 25. (426 aa)
SOX10SRY-box transcription factor 10. (604 aa)
POU4F2POU domain protein. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
CTNNB1Catenin beta 1. (783 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
NUMBLNUMB like endocytic adaptor protein. (678 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
LRP2LDL receptor related protein 2. (4646 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1694 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
NPTNNeuroplastin. (446 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
SRRTSerrate, RNA effector molecule. (876 aa)
XRCC2X-ray repair cross complementing 2. (276 aa)
PAX6Paired box 6. (437 aa)
UFL1UFM1 specific ligase 1. (792 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (769 aa)
EGR2Early growth response 2. (541 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (383 aa)
RNF112Ring finger protein 112. (629 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
FN1Fibronectin 1. (2475 aa)
MAN2A1Alpha-mannosidase. (1145 aa)
CUL7Cullin 7; Belongs to the cullin family. (1695 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PLXNB2Plexin B2. (1841 aa)
GLI3GLI family zinc finger 3. (1578 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
KDM1ALysine demethylase 1A. (944 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SS18L1SS18L1 subunit of BAF chromatin remodeling complex. (402 aa)
KRASUncharacterized protein. (380 aa)
CLCF1Cardiotrophin like cytokine factor 1. (340 aa)
TRIM32Uncharacterized protein. (669 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
SRFSerum response factor. (512 aa)
NOTCH1Notch receptor 1. (2543 aa)
SHTN1Shootin 1. (631 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
ASPAAspartoacylase. (313 aa)
PKHD1L1PKHD1 like 1. (4242 aa)
DBN1Drebrin 1. (703 aa)
CAPRIN1Cell cycle associated protein 1. (709 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
GSX2GS homeobox 2. (305 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
PTNPleiotrophin. (179 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
MAP6Microtubule associated protein 6. (770 aa)
BHLHB9Arm_2 domain-containing protein. (550 aa)
LIG4DNA ligase. (911 aa)
IL34Interleukin 34. (331 aa)
JADE2Jade family PHD finger 2. (827 aa)
NKX6-1NK6 homeobox 1. (367 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
METRNLMeteorin like, glial cell differentiation regulator. (310 aa)
CDKL3Cyclin dependent kinase like 3. (581 aa)
NINNinein. (2128 aa)
METRNMeteorin, glial cell differentiation regulator. (434 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)
OLIG2BHLH domain-containing protein. (519 aa)
DISC1DISC1 scaffold protein. (877 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
DCTDopachrome tautomerase. (664 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (855 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
PLXNC1Plexin C1. (1576 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
LIMK1LIM domain kinase 1. (763 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PLXNA2Plexin A2. (1911 aa)
BIN1Bridging integrator 1. (608 aa)
SOX8SRY-box 8. (883 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (353 aa)
CAPRIN2Caprin family member 2. (1019 aa)
LRP8LDL receptor related protein 8. (1015 aa)
FAIMFas apoptotic inhibitory molecule. (201 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ZNF365Zinc finger protein 365. (407 aa)
OBSL1Obscurin like 1. (2117 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (420 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
DMRTA2DMRT like family A2. (535 aa)
PLAG1PLAG1 zinc finger. (499 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
TENM4Teneurin transmembrane protein 4. (2823 aa)
CHODLChondrolectin. (272 aa)
DHX36DEAH-box helicase 36. (1012 aa)
LAYNLayilin. (380 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
NKX6-2NK6 homeobox 2. (285 aa)
FOXG1Forkhead box G1. (483 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
NUMBNUMB endocytic adaptor protein. (653 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PLXNA4Plexin A4. (1893 aa)
CUX2Homeobox protein cut-like. (1499 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1021 aa)
XRCC5X-ray repair cross complementing 5. (747 aa)
GOLGA4Golgin A4. (2306 aa)
PLXNB3Plexin B3. (2058 aa)
FBXW8F-box and WD repeat domain containing 8. (701 aa)
TGM2Transglutaminase 2. (733 aa)
ENSFCAP00000056200MOEP19 domain-containing protein. (399 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (246 aa)
RELNReelin. (3460 aa)
NTN1Netrin 1. (715 aa)
ZNF335Zinc finger protein 335. (1446 aa)
SPENSpen family transcriptional repressor. (3678 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
DBNLDrebrin like. (522 aa)
ZNF488Zinc finger protein 488. (233 aa)
PLXNA3Plexin A3. (1872 aa)
OTPOrthopedia homeobox. (415 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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