STRINGSTRING
CACTIN CACTIN ISG15 ISG15 NLRX1 NLRX1 TRIM21 TRIM21 SAMHD1 SAMHD1 GPR17 GPR17 IL10 IL10 PGLYRP2 PGLYRP2 IL2 IL2 C4BPB C4BPB IL27RA IL27RA CD55 CD55 IRAK3 IRAK3 ANXA1 ANXA1 MUL1 MUL1 LOC101101073 LOC101101073 SERPING1 SERPING1 TNFAIP3 TNFAIP3 GRN GRN ADAR ADAR CD160 CD160 CD59 CD59 LOC102899273 LOC102899273 PTPRC PTPRC TRAFD1 TRAFD1 CR2 CR2 LOC101094152 LOC101094152 SUSD4 SUSD4 CD84 CD84 VSIG4 VSIG4 YTHDF3 YTHDF3 LOC102899713 LOC102899713 OPRD1 OPRD1 NDFIP1 NDFIP1 KLRD1 KLRD1 CR1L CR1L CSMD3 CSMD3 RC3H1 RC3H1 ATG5 ATG5 RC3H2 RC3H2 PDCD1 PDCD1 ENSFCAP00000044386 ENSFCAP00000044386 CLEC12B CLEC12B FOXP3 FOXP3 PTPN2 PTPN2 FAM3A FAM3A SAMSN1 SAMSN1 SMAD7 SMAD7 NCKAP1L NCKAP1L USP15 USP15 LOC101088701 LOC101088701 PARP3 PARP3 FGL2 FGL2 C4BPA C4BPA METTL3 METTL3 ARG2 ARG2 ENPP3 ENPP3 STAT6 STAT6 COL3A1 COL3A1 SPINK5 SPINK5 DUSP10 DUSP10 OTOP1 OTOP1 DCST1 DCST1 ZBTB7B ZBTB7B IL1RL1 IL1RL1 BCR BCR FOXF1 FOXF1 NLRP6 NLRP6 TREX1 TREX1 LYAR LYAR SOCS5 SOCS5 CNOT7 CNOT7 CLEC4G CLEC4G IL20RB IL20RB DHX58 DHX58 IL4 IL4 TREM2 TREM2 NLRC5 NLRC5 SLAMF1 SLAMF1 PTPN6 PTPN6 IFNB1 IFNB1 CD96 CD96 TRIM27 TRIM27 LOC101082108 LOC101082108 SELENOS SELENOS THOC1 THOC1 FCRLB FCRLB PPP3CB PPP3CB IL12B IL12B HAVCR2 HAVCR2 LOC101081297 LOC101081297 RABGEF1 RABGEF1 HLX HLX AHR AHR FOXJ1 FOXJ1 HFE HFE BCL6 BCL6 ATG12 ATG12 MKRN2 MKRN2 NMI NMI NOD2 NOD2 ZC3H12A ZC3H12A TBX21 TBX21 INPP5D INPP5D PSMA1 PSMA1 STAT2 STAT2 TTLL12 TTLL12 TYRO3 TYRO3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACTINCactin, spliceosome C complex subunit. (754 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
NLRX1NLR family member X1. (975 aa)
TRIM21Tripartite motif containing 21. (469 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
PGLYRP2Peptidoglycan recognition protein 2. (605 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
C4BPBComplement component 4 binding protein beta. (259 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
CD55Uncharacterized protein. (464 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (551 aa)
ANXA1Annexin. (407 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
LOC101101073Uncharacterized protein. (971 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (512 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
GRNGranulin precursor. (596 aa)
ADARAdenosine deaminase RNA specific. (995 aa)
CD160CD160 molecule. (221 aa)
CD59UPAR/Ly6 domain-containing protein. (131 aa)
LOC102899273Uncharacterized protein. (401 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
TRAFD1TRAF-type zinc finger domain containing 1. (586 aa)
CR2Complement C3d receptor 2. (1474 aa)
LOC101094152Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (353 aa)
SUSD4Sushi domain containing 4. (525 aa)
CD84CD84 molecule. (369 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (593 aa)
LOC102899713Uncharacterized protein. (190 aa)
OPRD1YTH N6-methyladenosine RNA binding protein 2. (600 aa)
NDFIP1Nedd4 family interacting protein 1. (224 aa)
KLRD1Killer cell lectin like receptor D1. (186 aa)
CR1LUncharacterized protein. (923 aa)
CSMD3CUB and Sushi multiple domains 3. (3707 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
PDCD1Programmed cell death 1. (278 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
FOXP3Forkhead box P3. (501 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
FAM3AFamily with sequence similarity 3 member A. (364 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (441 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (790 aa)
LOC101088701Ig-like domain-containing protein. (370 aa)
PARP3Poly [ADP-ribose] polymerase. (538 aa)
FGL2Fibrinogen like 2. (440 aa)
C4BPAUncharacterized protein. (599 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (558 aa)
ARG2Arginase. (354 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1061 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
OTOP1Otopetrin 1. (607 aa)
DCST1DC-STAMP domain containing 1. (806 aa)
ZBTB7BUncharacterized protein. (540 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
FOXF1Forkhead box F1. (459 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
LYARLy1 antibody reactive. (384 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
IL20RBInterleukin 20 receptor subunit beta. (294 aa)
DHX58DExH-box helicase 58. (685 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
NLRC5NLR family CARD domain containing 5. (1844 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
CD96CD96 molecule. (571 aa)
TRIM27Tripartite motif containing 27. (513 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
SELENOSSelenoprotein S. (188 aa)
THOC1THO complex 1. (757 aa)
FCRLBFc receptor like B. (665 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
LOC101081297Ig-like domain-containing protein; Belongs to the MHC class I family. (355 aa)
RABGEF1Uncharacterized protein. (491 aa)
HLXH2.0 like homeobox. (569 aa)
AHRUncharacterized protein. (849 aa)
FOXJ1Forkhead box J1. (417 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
BCL6BCL6 transcription repressor. (745 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
NMIN-myc and STAT interactor. (309 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
TBX21T-box transcription factor 21. (535 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1181 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
STAT2Signal transducer and activator of transcription. (855 aa)
TTLL12Tubulin tyrosine ligase like 12. (767 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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