STRINGSTRING
NCLN NCLN PTEN PTEN APOA1 APOA1 TTI2 TTI2 CLU CLU CSN3 CSN3 LAMP1 LAMP1 CCT7 CCT7 P3H1 P3H1 THAP2 THAP2 ENSFCAP00000061275 ENSFCAP00000061275 STK3 STK3 ENSFCAP00000060491 ENSFCAP00000060491 PLPP3 PLPP3 SMO SMO MUL1 MUL1 EFNA1 EFNA1 ATP1B2 ATP1B2 ENSFCAP00000057489 ENSFCAP00000057489 GRN GRN CCNH CCNH ENSFCAP00000057069 ENSFCAP00000057069 RASSF2 RASSF2 AK6 AK6 COG7 COG7 ENSFCAP00000053301 ENSFCAP00000053301 TRIM39 TRIM39 SOX4 SOX4 ZBED3 ZBED3 HIP1 HIP1 ZSWIM7 ZSWIM7 DSG1 DSG1 ENSFCAP00000048998 ENSFCAP00000048998 WFS1 WFS1 CSN1S1 CSN1S1 MSX1 MSX1 TSPAN16 TSPAN16 ASDURF ASDURF CHEK2 CHEK2 STXBP4 STXBP4 PDCL3 PDCL3 MFSD1 MFSD1 GLMP GLMP TP53 TP53 USP2 USP2 C10orf90 C10orf90 BAG2 BAG2 TSC1 TSC1 PRKN PRKN PFN2 PFN2 SMAD7 SMAD7 CDC37L1 CDC37L1 BAG4 BAG4 GET1 GET1 PHB PHB CTNND1 CTNND1 WNT10B WNT10B TRIM75P TRIM75P HSP90AA1 HSP90AA1 SOX17 SOX17 A1CF A1CF CCT3 CCT3 ZNF207 ZNF207 FLNA FLNA RABL3 RABL3 PRKRA PRKRA FLOT2 FLOT2 USP7 USP7 TRIM44 TRIM44 SAV1 SAV1 MCM8 MCM8 PIK3R1 PIK3R1 NAA16 NAA16 NOP53 NOP53 TELO2 TELO2 SLC29A1 SLC29A1 PEX6 PEX6 CDC37 CDC37 PIN1 PIN1 CLUL1 CLUL1 BAG1 BAG1 TMEM88 TMEM88 CCT4 CCT4 ATF7IP ATF7IP IFI30 IFI30 CRYAB CRYAB ATP1B3 ATP1B3 BAG3 BAG3 STK4 STK4 PARK7 PARK7 USP33 USP33 PIM2 PIM2 RPAP3 RPAP3 CREBL2 CREBL2 SAXO2 SAXO2 STX12 STX12 TREX1 TREX1 OTUD3 OTUD3 PIM1 PIM1 CREB1 CREB1 AHSP AHSP DVL3 DVL3 EPHA4 EPHA4 FLOT1 FLOT1 DVL1 DVL1 NLK NLK GAPDH GAPDH HYPK HYPK HIP1R HIP1R SUGT1 SUGT1 EP300 EP300 COG3 COG3 SAXO1 SAXO1 CDK7 CDK7 AAK1 AAK1 LAMP2 LAMP2 BAG6 BAG6 PEX19 PEX19 MORC3 MORC3 TCP1 TCP1 CCT2 CCT2 PINK1 PINK1 FBXW7 FBXW7 TSPAN1 TSPAN1 CALR CALR CRYAA CRYAA FBXW9 FBXW9 ENSFCAP00000031119 ENSFCAP00000031119 TBRG1 TBRG1 PPIB PPIB ENSFCAP00000028340 ENSFCAP00000028340 USP19 USP19 USP9X USP9X AFM AFM CAMLG CAMLG COA8 COA8 NAA15 NAA15 BAG5 BAG5 SYVN1 SYVN1 LOC101098376 LOC101098376 USP13 USP13 TAF9B TAF9B TRIM60 TRIM60 HPS4 HPS4 USP36 USP36 PHB2 PHB2 PDCD10 PDCD10 RTN4 RTN4 MARCHF7 MARCHF7 WDR81 WDR81 M3X4Q0_FELCA M3X4Q0_FELCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCLNNicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. (563 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
APOA1Apolipoprotein A1. (295 aa)
TTI2TELO2 interacting protein 2. (507 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (182 aa)
LAMP1Lysosomal associated membrane protein 1. (422 aa)
CCT7T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
P3H1Prolyl 3-hydroxylase 1. (776 aa)
THAP2Transmembrane protein 19. (348 aa)
ENSFCAP00000061275Uncharacterized protein. (97 aa)
STK3Serine/threonine kinase 3. (573 aa)
ENSFCAP00000060491Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (308 aa)
PLPP3acidPPc domain-containing protein. (324 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (357 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
ENSFCAP00000057489Uncharacterized protein. (192 aa)
GRNGranulin precursor. (596 aa)
CCNHCyclin H; Belongs to the cyclin family. (326 aa)
ENSFCAP00000057069Uncharacterized protein. (103 aa)
RASSF2Ras association domain family member 2. (375 aa)
AK6Adenylate kinase 6. (268 aa)
COG7Component of oligomeric golgi complex 7. (770 aa)
ENSFCAP00000053301Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (133 aa)
TRIM39Tripartite motif containing 39. (517 aa)
SOX4Transcription factor SOX. (459 aa)
ZBED3Zinc finger BED-type containing 3. (236 aa)
HIP1Huntingtin interacting protein 1. (1036 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (145 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1074 aa)
ENSFCAP00000048998CDC37_N domain-containing protein. (55 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
CSN1S1Casein alpha s1. (183 aa)
MSX1Msh homeobox 1. (303 aa)
TSPAN16Uncharacterized protein. (157 aa)
ASDURFASNSD1 upstream reading frame. (96 aa)
CHEK2Checkpoint kinase 2. (569 aa)
STXBP4Uncharacterized protein. (562 aa)
PDCL3Phosducin like 3. (240 aa)
MFSD1Major facilitator superfamily domain containing 1. (468 aa)
GLMPGlycosylated lysosomal membrane protein. (488 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
C10orf90Chromosome 10 open reading frame 90. (655 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
TSC1TSC complex subunit 1. (1110 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
CDC37L1Cell division cycle 37 like 1. (337 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
GET1Guided entry of tail-anchored proteins factor 1. (174 aa)
PHBProhibitin. (272 aa)
CTNND1Catenin delta 1. (962 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TRIM75PTripartite motif containing 75, pseudogene. (469 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (753 aa)
SOX17SRY-box transcription factor 17. (406 aa)
A1CFAPOBEC1 complementation factor. (598 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
ZNF207Zinc finger protein 207. (538 aa)
FLNAFilamin A. (2808 aa)
RABL3RAB, member of RAS oncogene family like 3. (264 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (313 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (553 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
TRIM44Tripartite motif containing 44. (344 aa)
SAV1Salvador family WW domain containing protein 1. (395 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (833 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
NAA16N(alpha)-acetyltransferase 16, NatA auxiliary subunit. (873 aa)
NOP53NOP53 ribosome biogenesis factor. (485 aa)
TELO2Telomere maintenance 2. (824 aa)
SLC29A1Heat shock protein 90 alpha family class B member 1. (740 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
CDC37Uncharacterized protein. (377 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
CLUL1Clusterin; Belongs to the clusterin family. (468 aa)
BAG1BCL2 associated athanogene 1. (315 aa)
TMEM88Transmembrane protein 88. (159 aa)
CCT4T-complex protein 1 subunit delta. (628 aa)
ATF7IPActivating transcription factor 7 interacting protein. (1262 aa)
IFI30IFI30 lysosomal thiol reductase. (218 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
STK4Serine/threonine kinase 4. (487 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (912 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
RPAP3RNA polymerase II associated protein 3. (659 aa)
CREBL2cAMP responsive element binding protein like 2. (120 aa)
SAXO2Stabilizer of axonemal microtubules 2. (399 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
PIM1Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] (313 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
AHSPAlpha hemoglobin stabilizing protein. (92 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
EPHA4EPH receptor A4. (986 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
HYPKHuntingtin interacting protein K. (129 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
SUGT1SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (309 aa)
EP300E1A binding protein p300. (2425 aa)
COG3Component of oligomeric golgi complex 3. (828 aa)
SAXO1Stabilizer of axonemal microtubules 1. (477 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
AAK1AP2 associated kinase 1. (974 aa)
LAMP2Lysosomal associated membrane protein 2. (470 aa)
BAG6BCL2 associated athanogene 6. (1184 aa)
PEX19Peroxisomal biogenesis factor 19. (299 aa)
MORC3MORC family CW-type zinc finger 3. (939 aa)
TCP1T-complex 1. (556 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
PINK1PTEN induced kinase 1. (581 aa)
FBXW7F-box and WD repeat domain containing 7. (749 aa)
TSPAN1Tetraspanin. (241 aa)
CALRCalreticulin. (417 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (173 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
ENSFCAP00000031119Uncharacterized protein. (383 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
ENSFCAP00000028340Uncharacterized protein. (110 aa)
USP19Ubiquitin specific peptidase 19. (1380 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
AFMAfamin. (601 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (299 aa)
COA8Cytochrome c oxidase assembly factor 8. (205 aa)
NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit. (866 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
SYVN1Synoviolin 1. (612 aa)
LOC101098376Uncharacterized protein. (473 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
TAF9BTATA-box binding protein associated factor 9b. (260 aa)
TRIM60Tripartite motif containing 60. (471 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (698 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1102 aa)
PHB2Prohibitin. (299 aa)
PDCD10Programmed cell death 10. (212 aa)
RTN4Reticulon. (1190 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (705 aa)
WDR81WD repeat domain 81. (1943 aa)
M3X4Q0_FELCAGp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (215 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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