STRINGSTRING
RPL30 RPL30 TREM2 TREM2 ROMO1 ROMO1 CST11 CST11 HMGB2 HMGB2 BPI BPI IL22RA1 IL22RA1 IL17F IL17F BPIFC BPIFC IL23A IL23A MPEG1 MPEG1 LTF LTF F2 F2 RNASE6 RNASE6 M3X2M0_FELCA M3X2M0_FELCA TUSC2 TUSC2 LYPD8 LYPD8 TLR4 TLR4 IL12B IL12B PRKD1 PRKD1 ENSFCAP00000027292 ENSFCAP00000027292 DEFB114 DEFB114 AQP1 AQP1 DEFB119 DEFB119 DEFB127 DEFB127 IL17A IL17A DEFB1 DEFB1 LOC111560955 LOC111560955 TLR9 TLR9 GALP GALP DEFB136 DEFB136 ENSFCAP00000043380 ENSFCAP00000043380 ENSFCAP00000050360 ENSFCAP00000050360 DROSHA DROSHA ENSFCAP00000050838 ENSFCAP00000050838 PYCARD PYCARD RARRES2 RARRES2 LOC101098952 LOC101098952 ENSFCAP00000053107 ENSFCAP00000053107 CHGA CHGA ENSFCAP00000056035 ENSFCAP00000056035 SSC5D SSC5D ELANE ELANE CD160 CD160 GSDMD GSDMD LBP LBP TREM1 TREM1 LOC109498011 LOC109498011
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL30Ribosomal_L7Ae domain-containing protein. (115 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
CST11Cystatin 11. (138 aa)
HMGB2High mobility group box 2. (210 aa)
BPIBactericidal permeability increasing protein. (654 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (581 aa)
IL17FInterleukin 17F. (157 aa)
BPIFCBPI fold containing family C. (507 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
MPEG1Macrophage expressed 1. (717 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (154 aa)
M3X2M0_FELCAUncharacterized protein. (175 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
LYPD8UPAR/Ly6 domain-containing protein. (336 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
ENSFCAP00000027292Uncharacterized protein. (51 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (310 aa)
DEFB119Defensin beta 119. (86 aa)
DEFB127Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (100 aa)
IL17AInterleukin 17A. (155 aa)
DEFB1Defensin beta 1. (70 aa)
LOC111560955RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
GALPGalanin like peptide. (116 aa)
DEFB136Defensin beta 136. (78 aa)
ENSFCAP00000043380Uncharacterized protein. (75 aa)
ENSFCAP00000050360Uncharacterized protein. (97 aa)
DROSHADrosha ribonuclease III. (1374 aa)
ENSFCAP00000050838Ribosomal_L7Ae domain-containing protein. (124 aa)
PYCARDPYD and CARD domain containing. (195 aa)
RARRES2Retinoic acid receptor responder 2. (451 aa)
LOC101098952Ribosomal_L7Ae domain-containing protein. (124 aa)
ENSFCAP00000053107Ribosomal_L7Ae domain-containing protein. (111 aa)
CHGAChromogranin A. (566 aa)
ENSFCAP00000056035Uncharacterized protein. (111 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1541 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa)
CD160CD160 molecule. (221 aa)
GSDMDGasdermin D. (531 aa)
LBPLipopolysaccharide binding protein. (497 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (301 aa)
LOC109498011Uncharacterized protein. (483 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.