STRINGSTRING
IL12RB1 IL12RB1 SOCS5 SOCS5 PCK1 PCK1 DHPS DHPS CCDC88B CCDC88B SCRIB SCRIB CRTAM CRTAM PRELID1 PRELID1 CLEC4G CLEC4G BTNL2 BTNL2 IL20RB IL20RB MYB MYB NCK2 NCK2 KAT2A KAT2A STAT5B STAT5B IL4 IL4 SOX13 SOX13 TMEM131L TMEM131L IDO1 IDO1 TNFRSF1B TNFRSF1B SLAMF1 SLAMF1 CD4 CD4 PTPN6 PTPN6 AGER AGER IFNB1 IFNB1 ABL1 ABL1 MAD1L1 MAD1L1 TNFAIP8L2 TNFAIP8L2 RIPK3 RIPK3 EGR3 EGR3 SASH3 SASH3 FOXJ1 FOXJ1 IL2RA IL2RA IL1B IL1B TNFSF11 TNFSF11 HFE HFE TOX TOX IL21 IL21 BCL6 BCL6 LAG3 LAG3 TSPAN32 TSPAN32 CD81 CD81 ZC3H8 ZC3H8 IL1A IL1A FOXN1 FOXN1 NOD2 NOD2 ZC3H12A ZC3H12A ITCH ITCH IFNG IFNG CD274 CD274 PDCD1LG2 PDCD1LG2 SOCS6 SOCS6 LGALS9 LGALS9 TYK2 TYK2 CD80 CD80 LOC101090518 LOC101090518 ZAP70 ZAP70 TBX21 TBX21 IL6ST IL6ST ZP4 ZP4 IL12A IL12A FANCD2 FANCD2 ZMIZ1 ZMIZ1 RPS3 RPS3 GLI3 GLI3 LRRC32 LRRC32 IL23A IL23A B2M B2M IL27 IL27 RHOH RHOH ZNF683 ZNF683 BRAF BRAF VSIR VSIR IRF1 IRF1 ZP3 ZP3 AMBRA1 AMBRA1 CD6 CD6 IL2 IL2 MALT1 MALT1 ARG2 ARG2 SYK SYK CD28 CD28 SLC7A1 SLC7A1 EPHB6 EPHB6 PAG1 PAG1 DUSP10 DUSP10 RASAL3 RASAL3 LAT LAT PTEN PTEN RIPK2 RIPK2 IL15 IL15 ZBTB7B ZBTB7B LRRC1 LRRC1 IHH IHH SH3RF1 SH3RF1 ITPKB ITPKB HSPD1 HSPD1 ZBTB1 ZBTB1 ZBTB16 ZBTB16 NLRP3 NLRP3 TREX1 TREX1 TWSG1 TWSG1 TNFSF13B TNFSF13B LOC101082108 LOC101082108 ADORA2A ADORA2A IL6 IL6 SOS1 SOS1 FOXO3 FOXO3 MARCHF7 MARCHF7 PRKAR1B PRKAR1B GPNMB GPNMB SOS2 SOS2 PAWR PAWR ENSFCAP00000025816 ENSFCAP00000025816 IL12B IL12B CBLB CBLB TNFSF14 TNFSF14 PELI1 PELI1 BMI1 BMI1 IL18 IL18 DOCK8 DOCK8 HAVCR2 HAVCR2 CAV1 CAV1 ZEB1 ZEB1 ENSFCAP00000030239 ENSFCAP00000030239 ENSFCAP00000030418 ENSFCAP00000030418 PRNP PRNP IGFBP2 IGFBP2 ENSFCAP00000031202 ENSFCAP00000031202 TNFSF9 TNFSF9 CD83 CD83 CASP3 CASP3 HLX HLX NRARP NRARP IL7 IL7 CD40LG CD40LG LEP LEP IGF2 IGF2 TFRC TFRC SLC26A3-2 SLC26A3-2 TNFRSF21 TNFRSF21 CARD11 CARD11 FLOT2 FLOT2 PLA2G2F PLA2G2F PPP3CA PPP3CA DLG5 DLG5 DPP4 DPP4 LOC101082653 LOC101082653 CORO1A CORO1A ADAM8 ADAM8 CCR7 CCR7 NCK1 NCK1 PRDM1 PRDM1 FGL2 FGL2 ENSFCAP00000039745 ENSFCAP00000039745 SOX12 SOX12 ENSFCAP00000040186 ENSFCAP00000040186 ENSFCAP00000040280 ENSFCAP00000040280 KAT5 KAT5 SPTA1 SPTA1 LGALS3 LGALS3 LOC101084962 LOC101084962 PRKCQ PRKCQ LOC101088701 LOC101088701 CTLA4 CTLA4 LOC101090265 LOC101090265 FAM49B FAM49B VTCN1 VTCN1 XBP1 XBP1 ENSFCAP00000041710 ENSFCAP00000041710 GLMN GLMN WNT10B WNT10B NCKAP1L NCKAP1L SMAD7 SMAD7 THY1 THY1 TNFSF18 TNFSF18 PTPN2 PTPN2 FOXP3 FOXP3 GATA3 GATA3 LOC111558970 LOC111558970 FADD FADD LOC101082906 LOC101082906 FANCA FANCA CYP26B1 CYP26B1 LOC111560445 LOC111560445 CBFB CBFB EFNB3 EFNB3 TIGIT TIGIT RC3H2 RC3H2 SHB SHB LOC101090771 LOC101090771 ILDR2 ILDR2 TNFRSF9 TNFRSF9 BAD BAD FGL1 FGL1 RC3H1 RC3H1 TRAF6 TRAF6 SOCS1 SOCS1 LOC101100430 LOC101100430 SART1 SART1 LOC101081130 LOC101081130 LEF1 LEF1 DLG2 DLG2 DUSP3 DUSP3 PRKAR1A PRKAR1A CEBPB CEBPB IL2RG IL2RG MAPK8IP1 MAPK8IP1 GPAM GPAM BCL10 BCL10 DROSHA DROSHA DLG1 DLG1 PYCARD PYCARD LAX1 LAX1 BMP4 BMP4 HES1 HES1 LOC111560444 LOC111560444 LOC101084108 LOC101084108 NDFIP1 NDFIP1 RAC3 RAC3 ENSFCAP00000052528 ENSFCAP00000052528 ENSFCAP00000052659 ENSFCAP00000052659 RIPOR2 RIPOR2 NFKBIZ NFKBIZ LOC101085539 LOC101085539 LOC111560440 LOC111560440 TNFRSF13C TNFRSF13C VSIG4 VSIG4 SLC46A2 SLC46A2 LOC101083890 LOC101083890 PRKCZ PRKCZ FCHO1 FCHO1 STAT5A STAT5A RASGRP1 RASGRP1 RAC2 RAC2 PTPRC PTPRC PLA2G2D PLA2G2D FECA-DRB FECA-DRB CD160 CD160 LOC111556176 LOC111556176 LOC101086051 LOC101086051 ADA ADA HMGB1 HMGB1 TNFSF4 TNFSF4 ENSFCAP00000058589 ENSFCAP00000058589 CD5 CD5 SIRPA SIRPA LOC111556169 LOC111556169 CD86 CD86 LOC111560443 LOC111560443 SPN SPN LOC111556173 LOC111556173 AIF1 AIF1 ICOS ICOS ENSFCAP00000060822 ENSFCAP00000060822 ANXA1 ANXA1 SHH SHH APOE APOE CCL19 CCL19 IL27RA IL27RA EFNB1 EFNB1 CD27 CD27 PTPN22 PTPN22
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
DHPSDeoxyhypusine synthase. (369 aa)
CCDC88BCoiled-coil domain containing 88B. (1533 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
PRELID1PRELI domain containing 1. (219 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
BTNL2Butyrophilin like 2. (487 aa)
IL20RBInterleukin 20 receptor subunit beta. (294 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
NCK2Cytoplasmic protein. (380 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
SOX13SRY-box 13. (619 aa)
TMEM131LTransmembrane 131 like. (1609 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
CD4CD4 molecule. (487 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (916 aa)
TNFAIP8L2TNF alpha induced protein 8 like 2. (184 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (509 aa)
EGR3Early growth response 3. (392 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
FOXJ1Forkhead box J1. (417 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
TOXThymocyte selection associated high mobility group box. (523 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
BCL6BCL6 transcription repressor. (745 aa)
LAG3Lymphocyte activating 3. (513 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (289 aa)
CD81Tetraspanin. (236 aa)
ZC3H8Zinc finger CCCH-type containing 8. (311 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
FOXN1Forkhead box N1. (646 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
CD274CD274 molecule. (297 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (302 aa)
SOCS6Suppressor of cytokine signaling 6. (497 aa)
LGALS9Galectin. (356 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TBX21T-box transcription factor 21. (535 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
ZP4Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor; Belongs to the ZP domain family. ZPB subfamily. (570 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
FANCD2FA complementation group D2. (1450 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
GLI3GLI family zinc finger 3. (1578 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
IL27Interleukin 27. (236 aa)
RHOHRas homolog family member H. (191 aa)
ZNF683Zinc finger protein 683. (600 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
IRF1Interferon regulatory factor. (322 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (435 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
CD6CD6 molecule. (678 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
MALT1MALT1 paracaspase. (848 aa)
ARG2Arginase. (354 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
SLC7A1Solute carrier family 7 member 1. (803 aa)
EPHB6EPH receptor B6. (1012 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (434 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
RASAL3RAS protein activator like 3. (1012 aa)
LATLinker for activation of T cells. (231 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
ZBTB7BUncharacterized protein. (540 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
SH3RF1SH3 domain containing ring finger 1. (889 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
ZBTB16Zinc finger and BTB domain containing 16. (679 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (357 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FOXO3Forkhead box O3. (672 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (705 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
GPNMBGlycoprotein nmb. (568 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PAWRPro-apoptotic WT1 regulator. (347 aa)
ENSFCAP00000025816Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
CBLBCbl proto-oncogene B. (1182 aa)
TNFSF14Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (242 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
BMI1Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2101 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
ENSFCAP00000030239Uncharacterized protein. (145 aa)
ENSFCAP00000030418KH type-2 domain-containing protein. (147 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
IGFBP2Insulin like growth factor binding protein 2. (330 aa)
ENSFCAP00000031202Uncharacterized protein. (94 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (250 aa)
CD83CD83 molecule. (391 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
HLXH2.0 like homeobox. (569 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
IL7Interleukin 7. (158 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
IGF2Insulin like growth factor 2. (280 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
TNFRSF21TNF receptor superfamily member 21. (651 aa)
CARD11Caspase recruitment domain family member 11. (1163 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (553 aa)
PLA2G2FPhospholipase A(2). (211 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
DPP4Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (765 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (655 aa)
ADAM8ADAM metallopeptidase domain 8. (872 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
NCK1Cytoplasmic protein. (455 aa)
PRDM1PR/SET domain 1. (821 aa)
FGL2Fibrinogen like 2. (440 aa)
ENSFCAP00000039745Uncharacterized protein. (55 aa)
SOX12Transcription factor SOX. (314 aa)
ENSFCAP00000040186Ig-like domain-containing protein. (290 aa)
ENSFCAP00000040280Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
LGALS3Galectin. (278 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
LOC101088701Ig-like domain-containing protein. (370 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (268 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
FAM49BFamily with sequence similarity 49 member B. (378 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
XBP1X-box binding protein 1. (383 aa)
ENSFCAP00000041710Ig-like domain-containing protein. (255 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
THY1Thy-1 cell surface antigen. (161 aa)
TNFSF18TNF superfamily member 18. (178 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
FOXP3Forkhead box P3. (501 aa)
GATA3GATA binding protein 3. (444 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
FANCAFA complementation group A. (1476 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
LOC111560445Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
CBFBUncharacterized protein. (187 aa)
EFNB3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (312 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
SHBSH2 domain-containing protein. (508 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (644 aa)
TNFRSF9TNF receptor superfamily member 9. (263 aa)
BADBCL2 associated agonist of cell death. (273 aa)
FGL1Fibrinogen like 1. (378 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
LOC101100430Galectin. (138 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (803 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
LEF1Lymphoid enhancer binding factor 1. (415 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (703 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
DROSHADrosha ribonuclease III. (1374 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LAX1Lymphocyte transmembrane adaptor 1. (402 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
NDFIP1Nedd4 family interacting protein 1. (224 aa)
RAC3Rac family small GTPase 3. (205 aa)
ENSFCAP00000052528Uncharacterized protein. (499 aa)
ENSFCAP00000052659Uncharacterized protein. (184 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1162 aa)
NFKBIZNFKB inhibitor zeta. (956 aa)
LOC101085539Uncharacterized protein. (440 aa)
LOC111560440Ig-like domain-containing protein. (287 aa)
TNFRSF13CTNF receptor superfamily member 13C. (364 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
SLC46A2Solute carrier family 46 member 2. (500 aa)
LOC101083890Ig-like domain-containing protein. (285 aa)
PRKCZProtein kinase C zeta. (649 aa)
FCHO1FCH domain only 1. (1023 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
RAC2Rac family small GTPase 2. (234 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
PLA2G2DPhospholipase A(2). (145 aa)
FECA-DRBIg-like domain-containing protein. (344 aa)
CD160CD160 molecule. (221 aa)
LOC111556176Ig-like domain-containing protein. (285 aa)
LOC101086051Ig-like domain-containing protein. (159 aa)
ADAAdenosine deaminase. (431 aa)
HMGB1Uncharacterized protein. (233 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
ENSFCAP00000058589Uncharacterized protein. (93 aa)
CD5CD5 molecule. (524 aa)
SIRPAIg-like domain-containing protein. (287 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
SPNUncharacterized protein. (532 aa)
LOC111556173Ig-like domain-containing protein. (308 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
ICOSInducible T cell costimulator. (247 aa)
ENSFCAP00000060822Ig-like domain-containing protein. (252 aa)
ANXA1Annexin. (407 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
APOECLPTM1 regulator of GABA type A receptor forward trafficking. (688 aa)
CCL19C-C motif chemokine. (115 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
EFNB1Ephrin B1. (427 aa)
CD27CD27 molecule. (296 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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