STRINGSTRING
ENSFCAP00000044477 ENSFCAP00000044477 ENSFCAP00000044600 ENSFCAP00000044600 DAND5 DAND5 SMIM22 SMIM22 ENSFCAP00000046486 ENSFCAP00000046486 KDELR3 KDELR3 POLR2M POLR2M CIZ1 CIZ1 TAF8 TAF8 LRRN4CL LRRN4CL TAF3 TAF3 VPS13A VPS13A PINK1 PINK1 GBA GBA TAPT1 TAPT1 STAT5B STAT5B MORC3 MORC3 PML PML NFKBIB NFKBIB CRY2 CRY2 FTL FTL RANGAP1 RANGAP1 VPS13D VPS13D CD4 CD4 PFN4 PFN4 HK1 HK1 SCIN SCIN SUN1 SUN1 FITM1 FITM1 IL1B IL1B NRROS NRROS HK2 HK2 M3W5I8_FELCA M3W5I8_FELCA NFKBIA NFKBIA FTH1 FTH1 NRM NRM DGAT1 DGAT1 NRIP1 NRIP1 FFAR2 FFAR2 NR5A1 NR5A1 PLIN3 PLIN3 ANGPTL3 ANGPTL3 YWHAB YWHAB HSPA5 HSPA5 KEAP1 KEAP1 GM2A GM2A SORL1 SORL1 OS9 OS9 ZFYVE1 ZFYVE1 FBN1 FBN1 PLIN5 PLIN5 BSCL2 BSCL2 HEXB HEXB M3WRZ4_FELCA M3WRZ4_FELCA M3WSA8_FELCA M3WSA8_FELCA SUPT7L SUPT7L SRI SRI PARK7 PARK7 M3WYX4_FELCA M3WYX4_FELCA TWF2 TWF2 M3WZR3_FELCA M3WZR3_FELCA CDS2 CDS2 LOC101083747 LOC101083747 CDK5 CDK5 DBN1 DBN1 TOPORS TOPORS M3X4B2_FELCA M3X4B2_FELCA PSMD10 PSMD10 M3X4Z9_FELCA M3X4Z9_FELCA LATS1 LATS1 PNPLA2 PNPLA2 M3X6P5_FELCA M3X6P5_FELCA SQLE SQLE HEXA HEXA M3X8X8_FELCA M3X8X8_FELCA ASPM ASPM KDELR2 KDELR2 CDS1 CDS1 SPOUT1 SPOUT1 VPS13C VPS13C FTHL17 FTHL17 CRY1 CRY1 PAFAH1B1 PAFAH1B1 PKD2 PKD2 TBCCD1 TBCCD1 FITM2 FITM2 ENSFCAP00000027898 ENSFCAP00000027898 CCDC22 CCDC22 ENPP1 ENPP1 SLC30A7 SLC30A7 ENSFCAP00000059017 ENSFCAP00000059017 PKD1 PKD1 ENSFCAP00000058213 ENSFCAP00000058213 PLIN2 PLIN2 ENSFCAP00000057503 ENSFCAP00000057503 UVRAG UVRAG INSIG2 INSIG2 CREB3 CREB3 STAT5A STAT5A DZIP1 DZIP1 HNRNPU HNRNPU AUP1 AUP1 SOAT1 SOAT1 ENSFCAP00000054469 ENSFCAP00000054469 LOC101098498 LOC101098498 GSN GSN GAA GAA SYNE1 SYNE1 KDELR1 KDELR1 SUFU SUFU GPSM2 GPSM2 TMSB10 TMSB10 TNF TNF TSPO TSPO GET4 GET4 CER1 CER1 SLC30A8 SLC30A8 CCDC88A CCDC88A ALB ALB CAV1 CAV1 ACVR1C ACVR1C CD36 CD36 ENSFCAP00000031056 ENSFCAP00000031056 STARD4 STARD4 ENSFCAP00000031595 ENSFCAP00000031595 ATP7B ATP7B GOPC GOPC TWF1 TWF1 BBS4 BBS4 ENSFCAP00000034525 ENSFCAP00000034525 ARL2 ARL2 RER1 RER1 LOC101091822 LOC101091822 LOC101091569 LOC101091569 ENSFCAP00000038534 ENSFCAP00000038534 ENSFCAP00000038864 ENSFCAP00000038864 FLNA FLNA ENSFCAP00000039742 ENSFCAP00000039742 LDAH LDAH INSIG1 INSIG1 ANKRD13C ANKRD13C NR5A2 NR5A2 TXN TXN LTBP1 LTBP1 ARHGAP21 ARHGAP21 ATP2A1 ATP2A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSFCAP00000044477Uncharacterized protein. (43 aa)
ENSFCAP00000044600Uncharacterized protein. (66 aa)
DAND5DAN domain BMP antagonist family member 5. (190 aa)
SMIM22Small integral membrane protein 22. (91 aa)
ENSFCAP00000046486Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
KDELR3ER lumen protein-retaining receptor. (255 aa)
POLR2MRNA polymerase II subunit M. (366 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (851 aa)
TAF8TATA-box binding protein associated factor 8. (410 aa)
LRRN4CLLRRN4 C-terminal like. (240 aa)
TAF3TATA-box binding protein associated factor 3. (931 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3172 aa)
PINK1PTEN induced kinase 1. (581 aa)
GBAGlucosylceramidase. (536 aa)
TAPT1Transmembrane anterior posterior transformation 1. (780 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
MORC3MORC family CW-type zinc finger 3. (939 aa)
PMLPromyelocytic leukemia. (876 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
CRY2Cryptochrome circadian regulator 2. (594 aa)
FTLFerritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. (175 aa)
RANGAP1Ran GTPase activating protein 1. (587 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4389 aa)
CD4CD4 molecule. (487 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
HK1Hexokinase 1. (1056 aa)
SCINScinderin. (715 aa)
SUN1Sad1 and UNC84 domain containing 1. (940 aa)
FITM1Fat storage inducing transmembrane protein 1. (292 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
HK2Hexokinase 2. (917 aa)
M3W5I8_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FTH1Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (375 aa)
NRMNurim. (262 aa)
DGAT1O-acyltransferase. (493 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
PLIN3Perilipin; Belongs to the perilipin family. (438 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
GM2AGM2 ganglioside activator. (193 aa)
SORL1Sortilin related receptor 1. (2211 aa)
OS9OS9 endoplasmic reticulum lectin. (668 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (790 aa)
FBN1Fibrillin 1. (2871 aa)
PLIN5Perilipin; Belongs to the perilipin family. (460 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (464 aa)
HEXBBeta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family. (542 aa)
M3WRZ4_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
M3WSA8_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (173 aa)
SUPT7LSPT7 like, STAGA complex gamma subunit. (412 aa)
SRISorcin. (247 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
M3WYX4_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
M3WZR3_FELCAARL2_Bind_BART domain-containing protein. (163 aa)
CDS2Phosphatidate cytidylyltransferase; Belongs to the CDS family. (488 aa)
LOC101083747Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (256 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
DBN1Drebrin 1. (703 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1042 aa)
M3X4B2_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
M3X4Z9_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (193 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
PNPLA2Patatin like phospholipase domain containing 2. (486 aa)
M3X6P5_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
SQLESqualene epoxidase. (574 aa)
HEXABeta-hexosaminidase. (530 aa)
M3X8X8_FELCAFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
KDELR2ER lumen protein-retaining receptor. (212 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
SPOUT1SPOUT domain containing methyltransferase 1. (398 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3752 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
TBCCD1TBCC domain containing 1. (574 aa)
FITM2Fat storage inducing transmembrane protein 2. (294 aa)
ENSFCAP00000027898Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (235 aa)
CCDC22Coiled-coil domain containing 22. (631 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
SLC30A7Solute carrier family 30 member 7. (452 aa)
ENSFCAP00000059017Uncharacterized protein. (73 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
ENSFCAP00000058213Uncharacterized protein. (144 aa)
PLIN2Perilipin; Belongs to the perilipin family. (447 aa)
ENSFCAP00000057503Uncharacterized protein. (239 aa)
UVRAGUV radiation resistance associated. (718 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
DZIP1DAZ interacting zinc finger protein 1. (892 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (899 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (492 aa)
SOAT1O-acyltransferase. (566 aa)
ENSFCAP00000054469Thioredoxin domain-containing protein. (97 aa)
LOC101098498Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (294 aa)
GSNGelsolin. (815 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (1002 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8795 aa)
KDELR1ER lumen protein-retaining receptor. (442 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
GPSM2G protein signaling modulator 2. (767 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
TSPOUncharacterized protein. (257 aa)
GET4Golgi to ER traffic protein 4. (648 aa)
CER1Cerberus 1, DAN family BMP antagonist. (270 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
CCDC88ACoiled-coil domain containing 88A. (1874 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ENSFCAP00000031056Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (224 aa)
STARD4StAR related lipid transfer domain containing 4. (208 aa)
ENSFCAP00000031595Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
ATP7BATPase copper transporting beta. (1470 aa)
GOPCPDZ domain-containing protein. (463 aa)
TWF1Twinfilin actin binding protein 1. (357 aa)
BBS4Bardet-Biedl syndrome 4. (525 aa)
ENSFCAP00000034525Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (129 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
RER1Retention in endoplasmic reticulum sorting receptor 1. (435 aa)
LOC101091822Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (203 aa)
LOC101091569Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
ENSFCAP00000038534Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
ENSFCAP00000038864Uncharacterized protein. (100 aa)
FLNAFilamin A. (2808 aa)
ENSFCAP00000039742ARL2_Bind_BART domain-containing protein. (125 aa)
LDAHLipid droplet associated hydrolase. (336 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa)
ANKRD13CAnkyrin repeat domain 13C. (546 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1717 aa)
ARHGAP21Rho GTPase activating protein 21. (1950 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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