STRINGSTRING
OAS1 OAS1 PRF1 PRF1 IFNA1 IFNA1 ARMC5 ARMC5 CARD9 CARD9 IFI6 IFI6 RSAD2 RSAD2 EXOSC5 EXOSC5 IRF2 IRF2 TLR3 TLR3 ENSFCAP00000028517 ENSFCAP00000028517 ENSFCAP00000028308 ENSFCAP00000028308 BST2 BST2 LOC101086846 LOC101086846 POLR3K POLR3K IL12B IL12B RNASEL RNASEL BNIP3L BNIP3L TRIM13 TRIM13 IFNW1 IFNW1 NMBR NMBR TTC4 TTC4 DDX50 DDX50 IL6 IL6 LOC105259694 LOC105259694 TRIM27 TRIM27 PHB2 PHB2 TREX1 TREX1 TRIM35 TRIM35 IFIT3 IFIT3 IL-29 IL-29 LOC101088440 LOC101088440 IFIH1 IFIH1 RNASE6 RNASE6 DDIT4 DDIT4 NLRP6 NLRP6 TRIM32 TRIM32 NMB NMB TLR8 TLR8 SENP7 SENP7 KCNJ8 KCNJ8 IFNAR2 IFNAR2 ATAD3A ATAD3A M3WAV2_FELCA M3WAV2_FELCA DHX15 DHX15 SHFL SHFL OASL OASL AGBL5 AGBL5 IFNL1 IFNL1 DDX60 DDX60 ATG16L1 ATG16L1 IFIT2 IFIT2 IL23A IL23A STAT2 STAT2 ABCC9 ABCC9 SAMHD1 SAMHD1 BECN1 BECN1 IFI44L IFI44L IRF1 IRF1 POLR3C POLR3C CD207 CD207 LOC101094500 LOC101094500 OPRK1 OPRK1 MAP3K14 MAP3K14 BPIFA1 BPIFA1 MARCHF2 MARCHF2 ZDHHC1 ZDHHC1 LOC101093474 LOC101093474 LOC101100838 LOC101100838 EXOSC4 EXOSC4 ISG15 ISG15 MYD88 MYD88 POLR3F POLR3F LOC101099332 LOC101099332 TLR9 TLR9 ZMYND11 ZMYND11 IFNA13 IFNA13 TRIM21 TRIM21 VAMP8 VAMP8 TLR7 TLR7 IFNLR1 IFNLR1 TRIM11 TRIM11 CLEC4F CLEC4F PHB PHB IFNG IFNG TRIM25 TRIM25 ABCF3 ABCF3 IFIT5 IFIT5 AKAP1 AKAP1 POLR3H POLR3H EIF2AK2 EIF2AK2 IRF3 IRF3 UNC13D UNC13D CXCL10 CXCL10 RNF185 RNF185 FADD FADD CGAS CGAS G3BP1 G3BP1 DDX1 DDX1 IRF7 IRF7 DHX36 DHX36 NDUFAF4 NDUFAF4 CXCL9 CXCL9 LOC101100156 LOC101100156 PMAIP1 PMAIP1 GPAM GPAM STAT1 STAT1 PLA2G10 PLA2G10 PYCARD PYCARD LSM14A LSM14A IFIT1 IFIT1 LOC101091743 LOC101091743 ENSFCAP00000054410 ENSFCAP00000054410 AGBL4 AGBL4 PQBP1 PQBP1 TRIM8 TRIM8 TRIM56 TRIM56 PTPRC PTPRC ADAR ADAR POLR3A POLR3A ENSFCAP00000057442 ENSFCAP00000057442 LOC102899286 LOC102899286 MX1 MX1 RIPK3 RIPK3 CLPB CLPB NCBP3 NCBP3 APOBEC3Z3 APOBEC3Z3 ZBP1 ZBP1 ENSFCAP00000059570 ENSFCAP00000059570 LOC109502451 LOC109502451 BNIP3 BNIP3 TRIM28 TRIM28 SETD2 SETD2 ISG20 ISG20 ILF3 ILF3 IFNB1 IFNB1 SERINC5 SERINC5 PML PML DHX58 DHX58 TICAM2 TICAM2 STING1 STING1 ZNFX1 ZNFX1 DDX58 DDX58 NCBP1 NCBP1 IRF5 IRF5 DTX3L DTX3L MID2 MID2 CNOT7 CNOT7 RIOK3 RIOK3 SERINC3 SERINC3 FAM71E1 FAM71E1 OAS2 OAS2 OAS3 OAS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OAS12'-5'-oligoadenylate synthetase 1. (401 aa)
PRF1Perforin 1. (555 aa)
IFNA1Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa)
ARMC5Armadillo repeat containing 5. (943 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
IFI6Interferon alpha inducible protein 6. (149 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (363 aa)
EXOSC5Exosome component 5. (235 aa)
IRF2Interferon regulatory factor 2. (371 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
ENSFCAP00000028517Uncharacterized protein. (130 aa)
ENSFCAP00000028308Uncharacterized protein. (188 aa)
BST2Uncharacterized protein. (202 aa)
LOC101086846Uncharacterized protein. (125 aa)
POLR3KDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
RNASELRibonuclease L. (724 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
TRIM13Tripartite motif containing 13. (409 aa)
IFNW1Uncharacterized protein. (196 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
TTC4Tetratricopeptide repeat domain 4. (390 aa)
DDX50DExD-box helicase 50. (739 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
LOC105259694Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (337 aa)
TRIM27Tripartite motif containing 27. (513 aa)
PHB2Prohibitin. (299 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
TRIM35Tripartite motif containing 35. (493 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (489 aa)
IL-29Uncharacterized protein. (190 aa)
LOC101088440Uncharacterized protein. (183 aa)
IFIH1Interferon induced with helicase C domain 1. (1026 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (154 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
TRIM32Uncharacterized protein. (669 aa)
NMBNeuromedin B. (155 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
SENP7SUMO specific peptidase 7. (1052 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
IFNAR2Uncharacterized protein. (519 aa)
ATAD3AATPase family AAA domain containing 3A. (584 aa)
M3WAV2_FELCARING-type domain-containing protein. (222 aa)
DHX15DEAH-box helicase 15. (766 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (303 aa)
OASL2'-5'-oligoadenylate synthetase like. (515 aa)
AGBL5ATP/GTP binding protein like 5. (910 aa)
IFNL1Uncharacterized protein. (199 aa)
DDX60DExD/H-box helicase 60. (1707 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (469 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
STAT2Signal transducer and activator of transcription. (855 aa)
ABCC9ATP binding cassette subfamily C member 9. (1548 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
BECN1Beclin 1. (448 aa)
IFI44LInterferon induced protein 44 like. (331 aa)
IRF1Interferon regulatory factor. (322 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (557 aa)
CD207CD207 molecule. (329 aa)
LOC101094500Uncharacterized protein. (274 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (954 aa)
BPIFA1BPI fold containing family A member 1. (255 aa)
MARCHF2Membrane associated ring-CH-type finger 2. (246 aa)
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (480 aa)
LOC101093474Uncharacterized protein. (600 aa)
LOC101100838Uncharacterized protein. (124 aa)
EXOSC4Exosome component 4. (245 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
LOC101099332Uncharacterized protein. (520 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
ZMYND11Zinc finger MYND-type containing 11. (617 aa)
IFNA13Uncharacterized protein. (193 aa)
TRIM21Tripartite motif containing 21. (469 aa)
VAMP8Vesicle associated membrane protein 8. (99 aa)
TLR7TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa)
IFNLR1Interferon lambda receptor 1. (611 aa)
TRIM11Tripartite motif containing 11. (468 aa)
CLEC4FC-type lectin domain family 4 member F. (609 aa)
PHBProhibitin. (272 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
TRIM25Tripartite motif containing 25. (608 aa)
ABCF3ATP binding cassette subfamily F member 3. (709 aa)
IFIT5Uncharacterized protein. (482 aa)
AKAP1A-kinase anchoring protein 1. (974 aa)
POLR3HRNA polymerase III subunit H. (204 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (541 aa)
IRF3Interferon regulatory factor 3. (420 aa)
UNC13DUnc-13 homolog D. (1091 aa)
CXCL10C-X-C motif chemokine. (98 aa)
RNF185Ring finger protein 185. (192 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
CGASCyclic GMP-AMP synthase. (514 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
DDX1DEAD-box helicase 1. (740 aa)
IRF7Interferon regulatory factor 7. (512 aa)
DHX36DEAH-box helicase 36. (1012 aa)
NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4. (175 aa)
CXCL9C-X-C motif chemokine. (155 aa)
LOC101100156Uncharacterized protein. (511 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
PLA2G10Phospholipase A(2). (162 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LSM14ALSM14A mRNA processing body assembly factor. (469 aa)
IFIT1Interferon induced protein with tetratricopeptide repeats 1. (490 aa)
LOC101091743Uncharacterized protein. (185 aa)
ENSFCAP00000054410Uncharacterized protein. (229 aa)
AGBL4ATP/GTP binding protein like 4. (503 aa)
PQBP1Polyglutamine binding protein 1. (272 aa)
TRIM8Tripartite motif containing 8. (551 aa)
TRIM56Tripartite motif containing 56. (770 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
ADARAdenosine deaminase RNA specific. (995 aa)
POLR3ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa)
ENSFCAP00000057442Uncharacterized protein. (140 aa)
LOC102899286Uncharacterized protein. (367 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (675 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (509 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (706 aa)
NCBP3Nuclear cap binding subunit 3. (627 aa)
APOBEC3Z3CMP/dCMP-type deaminase domain-containing protein. (319 aa)
ZBP1Z-DNA binding protein 1. (446 aa)
ENSFCAP00000059570Uncharacterized protein. (141 aa)
LOC109502451Uncharacterized protein. (458 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
TRIM28Tripartite motif containing 28. (821 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
ISG20Interferon stimulated exonuclease gene 20. (171 aa)
ILF3Interleukin enhancer binding factor 3. (900 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
SERINC5Serine incorporator 5. (461 aa)
PMLPromyelocytic leukemia. (876 aa)
DHX58DExH-box helicase 58. (685 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
STING1Stimulator of interferon genes. (377 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
DDX58DExD/H-box helicase 58. (929 aa)
NCBP1Nuclear cap binding protein subunit 1. (789 aa)
IRF5Interferon regulatory factor 5. (504 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (738 aa)
MID2Midline 2. (735 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
SERINC3Serine incorporator 3. (473 aa)
FAM71E1Family with sequence similarity 71 member E1. (213 aa)
OAS22'-5'-oligoadenylate synthetase 2. (708 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (20%) [HD]