STRINGSTRING
VEGFA VEGFA YBX1 YBX1 FGF1 FGF1 AURKB AURKB CSPP1 CSPP1 SVIL SVIL DRD3 DRD3 ENSFCAP00000058166 ENSFCAP00000058166 LOC101088142 LOC101088142 CENPV CENPV PDGFA PDGFA PTN PTN FGF9 FGF9 PKN2 PKN2 KIF14 KIF14 FGF7 FGF7 RHOA RHOA GAREM1 GAREM1 HTR2B HTR2B PDGFB PDGFB TGFB3 TGFB3 GIPC1 GIPC1 CDC25B CDC25B NKX3-1 NKX3-1 RACGAP1 RACGAP1 IL1A IL1A VEGFC VEGFC FGF8 FGF8 GIPC3 GIPC3 VEGFB VEGFB IL1B IL1B TGFB1 TGFB1 CDC42 CDC42 THBS4 THBS4 NUP62CL NUP62CL CIT CIT CAT CAT LOC101094344 LOC101094344 PDGFC PDGFC SIRT2 SIRT2 CDC14A CDC14A ENSFCAP00000054808 ENSFCAP00000054808 ENSFCAP00000053370 ENSFCAP00000053370 PDGFD PDGFD CDC6 CDC6 CDC42-2 CDC42-2 CDC14B CDC14B GIPC2 GIPC2 ITGB1BP1 ITGB1BP1 TGFB2 TGFB2 FGF4 FGF4 BTC BTC IGF2 IGF2 PRKCE PRKCE ECT2 ECT2 HDGF HDGF TGFA TGFA GAREM2 GAREM2 MAP10 MAP10 CUL3 CUL3 CXCR5 CXCR5 FGF5 FGF5 PGF PGF FGF3 FGF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
YBX1Y-box binding protein 1. (388 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (408 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1226 aa)
SVILSupervillin. (2361 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
ENSFCAP00000058166CSD domain-containing protein. (268 aa)
LOC101088142GFA domain-containing protein. (262 aa)
CENPVGFA domain-containing protein. (297 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PTNPleiotrophin. (179 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PKN2Protein kinase N2. (983 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RHOARas homolog family member A. (193 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (876 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GIPC1GIPC PDZ domain containing family member 1. (447 aa)
CDC25BCell division cycle 25B. (578 aa)
NKX3-1NK3 homeobox 1. (231 aa)
RACGAP1Rac GTPase activating protein 1. (668 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CDC42Uncharacterized protein. (191 aa)
THBS4Thrombospondin 4. (964 aa)
NUP62CLNsp1_C domain-containing protein. (215 aa)
CITCitron rho-interacting serine/threonine kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1882 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (616 aa)
LOC101094344C-X-C motif chemokine. (113 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SIRT2Sirtuin 2. (497 aa)
CDC14ACell division cycle 14A. (598 aa)
ENSFCAP00000054808Uncharacterized protein. (786 aa)
ENSFCAP00000053370Uncharacterized protein. (87 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
CDC42-2Uncharacterized protein. (191 aa)
CDC14BUncharacterized protein. (529 aa)
GIPC2GIPC PDZ domain containing family member 2. (313 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (213 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
BTCBetacellulin. (194 aa)
IGF2Insulin like growth factor 2. (280 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ECT2Epithelial cell transforming 2. (914 aa)
HDGFHeparin binding growth factor. (282 aa)
TGFATransforming growth factor alpha. (192 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (869 aa)
MAP10Microtubule associated protein 10. (902 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
FGF5Fibroblast growth factor 5. (279 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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