(10 nodes) Positive regulation of type I interferon-mediated signaling pathway network (Felis catus)

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Your Input:
	ZBP1	Z-DNA binding protein 1. (446 aa)
	STING1	Stimulator of interferon genes. (377 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	RNF185	Ring finger protein 185. (192 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (469 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TRIM56	Tripartite motif containing 56. (770 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FADD	IRF3	ENSFCAP00000045141	ENSFCAP00000005645	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Interferon regulatory factor 3.	0.536
FADD	TBK1	ENSFCAP00000045141	ENSFCAP00000054160	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TANK binding kinase 1.	0.472
FADD	ZBP1	ENSFCAP00000045141	ENSFCAP00000059181	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Z-DNA binding protein 1.	0.507
IKBKE	IRF3	ENSFCAP00000012776	ENSFCAP00000005645	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon regulatory factor 3.	0.988
IKBKE	STING1	ENSFCAP00000012776	ENSFCAP00000001602	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Stimulator of interferon genes.	0.988
IKBKE	TBK1	ENSFCAP00000012776	ENSFCAP00000054160	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK binding kinase 1.	0.998
IKBKE	ZBP1	ENSFCAP00000012776	ENSFCAP00000059181	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Z-DNA binding protein 1.	0.942
IRF3	FADD	ENSFCAP00000005645	ENSFCAP00000045141	Interferon regulatory factor 3.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.536
IRF3	IKBKE	ENSFCAP00000005645	ENSFCAP00000012776	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.988
IRF3	STING1	ENSFCAP00000005645	ENSFCAP00000001602	Interferon regulatory factor 3.	Stimulator of interferon genes.	0.967
IRF3	TBK1	ENSFCAP00000005645	ENSFCAP00000054160	Interferon regulatory factor 3.	TANK binding kinase 1.	0.999
IRF3	TRIM56	ENSFCAP00000005645	ENSFCAP00000055879	Interferon regulatory factor 3.	Tripartite motif containing 56.	0.564
IRF3	ZBP1	ENSFCAP00000005645	ENSFCAP00000059181	Interferon regulatory factor 3.	Z-DNA binding protein 1.	0.949
LSM14A	TBK1	ENSFCAP00000052758	ENSFCAP00000054160	LSM14A mRNA processing body assembly factor.	TANK binding kinase 1.	0.462
STING1	IKBKE	ENSFCAP00000001602	ENSFCAP00000012776	Stimulator of interferon genes.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.988
STING1	IRF3	ENSFCAP00000001602	ENSFCAP00000005645	Stimulator of interferon genes.	Interferon regulatory factor 3.	0.967
STING1	TBK1	ENSFCAP00000001602	ENSFCAP00000054160	Stimulator of interferon genes.	TANK binding kinase 1.	0.999
STING1	TRIM56	ENSFCAP00000001602	ENSFCAP00000055879	Stimulator of interferon genes.	Tripartite motif containing 56.	0.813
TBK1	FADD	ENSFCAP00000054160	ENSFCAP00000045141	TANK binding kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.472
TBK1	IKBKE	ENSFCAP00000054160	ENSFCAP00000012776	TANK binding kinase 1.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.998