STRINGSTRING
GDNF GDNF TRIM28 TRIM28 EFNB1 EFNB1 SEMA6B SEMA6B ENSFCAP00000061110 ENSFCAP00000061110 SEMA3B SEMA3B SMO SMO KLHL12 KLHL12 FAM172A FAM172A EFNA1 EFNA1 ACTA1 ACTA1 TCOF1 TCOF1 JAG1 JAG1 ENSFCAP00000057918 ENSFCAP00000057918 ENSFCAP00000057780 ENSFCAP00000057780 ANXA6 ANXA6 AMH AMH OTUD5 OTUD5 LOC109492241 LOC109492241 ADAM15 ADAM15 AMER1 AMER1 SEMA4A SEMA4A SIX4 SIX4 PHACTR4 PHACTR4 ZIC3 ZIC3 PEF1 PEF1 LOC111559734 LOC111559734 HES1 HES1 BMP4 BMP4 SEMA4C SEMA4C LOC101093046 LOC101093046 YAP1 YAP1 HOXA5 HOXA5 GSC GSC TBX3 TBX3 SCX SCX MSX1 MSX1 SEMA5B SEMA5B LEF1 LEF1 NRP2 NRP2 TGFBR1 TGFBR1 NRTN NRTN NOG NOG SOX9 SOX9 EXT1 EXT1 PHOX2B PHOX2B SEMA6C SEMA6C HAND2 HAND2 GSK3B GSK3B TCF15 TCF15 ERBB4 ERBB4 TGFBR3L TGFBR3L ALDH1A2 ALDH1A2 HMGA2 HMGA2 PDCD6 PDCD6 RFLNB RFLNB EDNRA EDNRA SEMA5A SEMA5A WNT10A WNT10A SFRP2 SFRP2 FLNA FLNA SOX8 SOX8 ACVRL1 ACVRL1 TBX5 TBX5 DLL3 DLL3 ROCK1 ROCK1 DLG5 DLG5 WWTR1 WWTR1 CNRIP1 CNRIP1 BNC2 BNC2 SFRP1 SFRP1 GBX2 GBX2 SEMA6D SEMA6D MAPK3 MAPK3 SMAD3 SMAD3 HAS2 HAS2 FGF10 FGF10 TGFB2 TGFB2 ALX1 ALX1 SMAD4 SMAD4 BMP2 BMP2 MEF2C MEF2C RADIL RADIL WNT2 WNT2 DDX17 DDX17 LOC101092829 LOC101092829 TASOR TASOR SIX2 SIX2 PKD2 PKD2 CORO1C CORO1C SEMA6A SEMA6A MAPK1 MAPK1 SIX1 SIX1 MDM2 MDM2 POGLUT1 POGLUT1 SEMA4B SEMA4B SEMA3A SEMA3A BMPR1A BMPR1A WNT16 WNT16 ZFP36L1 ZFP36L1 SEMA3D SEMA3D RTN4 RTN4 CITED2 CITED2 FGF9 FGF9 EXOC4 EXOC4 TCF21 TCF21 WNT11 WNT11 OSR1 OSR1 NOTCH1 NOTCH1 RDH10 RDH10 SEMA3C SEMA3C SEMA3E SEMA3E FOXF1 FOXF1 HTR2B HTR2B SNAI2 SNAI2 SEMA3G SEMA3G SEMA4G SEMA4G TAF10 TAF10 GATA4 GATA4 HAND1 HAND1 ERBB3 ERBB3 EDN1 EDN1 BMPR2 BMPR2 ACTC1 ACTC1 FRZB FRZB TBX20 TBX20 RET RET LOXL2 LOXL2 TGFBR3 TGFBR3 ACTG2 ACTG2 KBTBD8 KBTBD8 SNAI1 SNAI1 CYP26C1 CYP26C1 MEOX1 MEOX1 PTK7 PTK7 CUL7 CUL7 HNF1A HNF1A FN1 FN1 TBX2 TBX2 MESP1 MESP1 SEMA7A SEMA7A ACVR1 ACVR1 ACTA2 ACTA2 LOXL3 LOXL3 SEMA3F SEMA3F NRP1 NRP1 TGFB1 TGFB1 PAX1 PAX1 SEMA4D SEMA4D DDX5 DDX5 HIF1A HIF1A SOX10 SOX10 TEAD2 TEAD2 ENG ENG NODAL NODAL GATA5 GATA5 RANBP3L RANBP3L NUP133 NUP133 TMEM100 TMEM100 AKNA AKNA LRP6 LRP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDNFGlial cell derived neurotrophic factor. (211 aa)
TRIM28Tripartite motif containing 28. (821 aa)
EFNB1Ephrin B1. (427 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (1296 aa)
ENSFCAP00000061110TGF_BETA_2 domain-containing protein. (362 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (777 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
KLHL12Kelch like family member 12. (838 aa)
FAM172AFamily with sequence similarity 172 member A. (470 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (357 aa)
ACTA1Actin alpha 1, skeletal muscle. (457 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1407 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
ENSFCAP00000057918Uncharacterized protein. (293 aa)
ENSFCAP00000057780Uncharacterized protein. (585 aa)
ANXA6Annexin. (723 aa)
AMHAnti-Mullerian hormone. (800 aa)
OTUD5OTU deubiquitinase 5. (583 aa)
LOC109492241Uncharacterized protein. (424 aa)
ADAM15ADAM metallopeptidase domain 15. (869 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (806 aa)
SIX4SIX homeobox 4. (784 aa)
PHACTR4Phosphatase and actin regulator. (752 aa)
ZIC3Zic family member 3. (553 aa)
PEF1Penta-EF-hand domain containing 1. (297 aa)
LOC111559734Bone morphogenetic protein 7. (426 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
LOC101093046Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (208 aa)
YAP1Yes associated protein 1. (498 aa)
HOXA5Homeobox A5. (381 aa)
GSCGoosecoid homeobox. (256 aa)
TBX3T-box transcription factor 3. (745 aa)
SCXScleraxis bHLH transcription factor. (203 aa)
MSX1Msh homeobox 1. (303 aa)
SEMA5BSemaphorin 5B. (1100 aa)
LEF1Lymphoid enhancer binding factor 1. (415 aa)
NRP2Neuropilin 2. (992 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
NRTNNeurturin. (197 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9SRY-box transcription factor 9. (511 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (1023 aa)
HAND2Heart and neural crest derivatives expressed 2. (275 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
TCF15Transcription factor 15. (197 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
TGFBR3LZP domain-containing protein. (485 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa)
HMGA2Uncharacterized protein. (109 aa)
PDCD6Programmed cell death 6. (189 aa)
RFLNBRefilin B. (218 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA5ASemaphorin 5A. (1116 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
FLNAFilamin A. (2808 aa)
SOX8SRY-box 8. (883 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
TBX5T-box transcription factor 5. (518 aa)
DLL3Delta like canonical Notch ligand 3. (589 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CNRIP1Uncharacterized protein. (324 aa)
BNC2Basonuclin 2. (1115 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1069 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
HAS2Hyaluronan synthase 2. (552 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ALX1ALX homeobox 1. (326 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
RADILRap associating with DIL domain. (1203 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
LOC101092829Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (165 aa)
TASORTranscription activation suppressor. (1665 aa)
SIX2SIX homeobox 2. (296 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
SIX1SIX homeobox 1. (284 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (773 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (798 aa)
RTN4Reticulon. (1190 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EXOC4Exocyst complex component 4. (975 aa)
TCF21Transcription factor 21. (179 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
NOTCH1Notch receptor 1. (2543 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (749 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
FOXF1Forkhead box F1. (459 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
SNAI2Uncharacterized protein. (268 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (768 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (840 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
GATA4GATA binding protein 4. (443 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
ERBB3ERBB3. (1339 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ACTC1Actin alpha cardiac muscle 1. (616 aa)
FRZBFrizzled related protein. (324 aa)
TBX20T-box transcription factor 20. (480 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)
LOXL2Lysyl oxidase like 2. (773 aa)
TGFBR3Transforming growth factor beta receptor 3. (828 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
MEOX1Mesenchyme homeobox 1. (307 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
CUL7Cullin 7; Belongs to the cullin family. (1695 aa)
HNF1AHNF1 homeobox A. (639 aa)
FN1Fibronectin 1. (2475 aa)
TBX2T-box transcription factor 2. (713 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (261 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (769 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
LOXL3Lysyl oxidase like 3. (974 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PAX1Paired box 1. (446 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
SOX10SRY-box transcription factor 10. (604 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ENGEndoglin. (654 aa)
NODALNodal growth differentiation factor. (348 aa)
GATA5GATA binding protein 5. (398 aa)
RANBP3LRAN binding protein 3 like. (491 aa)
NUP133Nucleoporin 133. (1155 aa)
TMEM100Transmembrane protein 100. (134 aa)
AKNAAT-hook transcription factor. (1405 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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