17 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNC	Tenascin C. (2200 aa)
	HOXB13	Homeobox B13. (285 aa)
	NKX3-1	NK3 homeobox 1. (231 aa)
	HOXA13	Homeobox A13. (389 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	RARG	Retinoic acid receptor gamma. (459 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FEM1B	Fem-1 homolog B. (627 aa)
	SOX9	SRY-box transcription factor 9. (511 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (543 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HOXD13	Homeobox D13. (341 aa)
	FOXA1	Forkhead box A1. (536 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
	NOTCH1	Notch receptor 1. (2543 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSFCAP00000051185	ENSFCAP00000032796	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
BMP4	NOG	ENSFCAP00000051185	ENSFCAP00000046242	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	NOTCH1	ENSFCAP00000051185	ENSFCAP00000020019	Bone morphogenetic protein 4.	Notch receptor 1.	0.410
BMP4	SOX9	ENSFCAP00000051185	ENSFCAP00000045943	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.625
ESR1	FOXA1	ENSFCAP00000020448	ENSFCAP00000020793	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Forkhead box A1.	0.921
ESR1	NOTCH1	ENSFCAP00000020448	ENSFCAP00000020019	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Notch receptor 1.	0.542
FGF10	BMP4	ENSFCAP00000032796	ENSFCAP00000051185	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.839
FGF10	FRS2	ENSFCAP00000032796	ENSFCAP00000039800	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2.	0.672
FGF10	NOG	ENSFCAP00000032796	ENSFCAP00000046242	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.839
FGF10	SOX9	ENSFCAP00000032796	ENSFCAP00000045943	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.576
FOXA1	ESR1	ENSFCAP00000020793	ENSFCAP00000020448	Forkhead box A1.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.921
FOXA1	HOXB13	ENSFCAP00000020793	ENSFCAP00000001961	Forkhead box A1.	Homeobox B13.	0.558
FOXA1	NKX3-1	ENSFCAP00000020793	ENSFCAP00000053227	Forkhead box A1.	NK3 homeobox 1.	0.567
FRS2	FGF10	ENSFCAP00000039800	ENSFCAP00000032796	Fibroblast growth factor receptor substrate 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.672
HOXB13	FOXA1	ENSFCAP00000001961	ENSFCAP00000020793	Homeobox B13.	Forkhead box A1.	0.558
NKX3-1	FOXA1	ENSFCAP00000053227	ENSFCAP00000020793	NK3 homeobox 1.	Forkhead box A1.	0.567
NOG	BMP4	ENSFCAP00000046242	ENSFCAP00000051185	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 4.	0.998
NOG	FGF10	ENSFCAP00000046242	ENSFCAP00000032796	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
NOG	SOX9	ENSFCAP00000046242	ENSFCAP00000045943	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	SRY-box transcription factor 9.	0.665
NOTCH1	BMP4	ENSFCAP00000020019	ENSFCAP00000051185	Notch receptor 1.	Bone morphogenetic protein 4.	0.410