(38 nodes) Positive regulation of response to cytokine stimulus network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	CPNE1	Copine 1. (542 aa)
	ZBP1	Z-DNA binding protein 1. (446 aa)
	TRIM56	Tripartite motif containing 56. (770 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (469 aa)
	ENSFCAP00000050553	Uncharacterized protein. (71 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
	RNF185	Ring finger protein 185. (192 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
	AXL	AXL receptor tyrosine kinase. (861 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	TRIM44	Tripartite motif containing 44. (344 aa)
	IL7	Interleukin 7. (158 aa)
	C1QTNF4	C1q domain-containing protein. (98 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1026 aa)
	NLRP6	NLR family pyrin domain containing 6. (878 aa)
	TRIM32	Uncharacterized protein. (669 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	DHX9	DExH-box helicase 9. (1373 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	TXK	Tyrosine-protein kinase. (551 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
	GAS6	Growth arrest specific 6. (674 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (422 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (258 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (234 aa)
	STING1	Stimulator of interferon genes. (377 aa)
	CD300LF	CD300 molecule like family member f. (384 aa)
	DDX58	DExD/H-box helicase 58. (929 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (828 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	CSF1	ENSFCAP00000035876	ENSFCAP00000010007	AXL receptor tyrosine kinase.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.558
AXL	FADD	ENSFCAP00000035876	ENSFCAP00000045141	AXL receptor tyrosine kinase.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.504
AXL	GAS6	ENSFCAP00000035876	ENSFCAP00000006408	AXL receptor tyrosine kinase.	Growth arrest specific 6.	0.999
AXL	PRKN	ENSFCAP00000035876	ENSFCAP00000043123	AXL receptor tyrosine kinase.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.403
AXL	TLR4	ENSFCAP00000035876	ENSFCAP00000023731	AXL receptor tyrosine kinase.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.420
AXL	TREM2	ENSFCAP00000035876	ENSFCAP00000002549	AXL receptor tyrosine kinase.	Triggering receptor expressed on myeloid cells 2.	0.812
CD300LF	TREM2	ENSFCAP00000001509	ENSFCAP00000002549	CD300 molecule like family member f.	Triggering receptor expressed on myeloid cells 2.	0.470
CSF1	AXL	ENSFCAP00000010007	ENSFCAP00000035876	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	AXL receptor tyrosine kinase.	0.558
CSF1	IL7	ENSFCAP00000010007	ENSFCAP00000032766	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interleukin 7.	0.543
CSF1	IRF3	ENSFCAP00000010007	ENSFCAP00000005645	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interferon regulatory factor 3.	0.425
CSF1	TLR4	ENSFCAP00000010007	ENSFCAP00000023731	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.620
CSF1	TREM2	ENSFCAP00000010007	ENSFCAP00000002549	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Triggering receptor expressed on myeloid cells 2.	0.562
DDX58	IFIH1	ENSFCAP00000001203	ENSFCAP00000019326	DExD/H-box helicase 58.	Interferon induced with helicase C domain 1.	0.890
DDX58	IKBKE	ENSFCAP00000001203	ENSFCAP00000012776	DExD/H-box helicase 58.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.591
DDX58	IRF3	ENSFCAP00000001203	ENSFCAP00000005645	DExD/H-box helicase 58.	Interferon regulatory factor 3.	0.797
DDX58	PARP9	ENSFCAP00000001203	ENSFCAP00000000516	DExD/H-box helicase 58.	Poly(ADP-ribose) polymerase family member 9.	0.768
DDX58	RIPK1	ENSFCAP00000001203	ENSFCAP00000013566	DExD/H-box helicase 58.	Receptor interacting serine/threonine kinase 1.	0.552
DDX58	STING1	ENSFCAP00000001203	ENSFCAP00000001602	DExD/H-box helicase 58.	Stimulator of interferon genes.	0.463
DDX58	TBK1	ENSFCAP00000001203	ENSFCAP00000054160	DExD/H-box helicase 58.	TANK binding kinase 1.	0.765
DDX58	TLR4	ENSFCAP00000001203	ENSFCAP00000023731	DExD/H-box helicase 58.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.487