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SIK1 | Uncharacterized protein. (780 aa) | ||||
ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa) | ||||
ABCG4 | ATP binding cassette subfamily G member 4. (673 aa) | ||||
PDZD3 | PDZ domain containing 3. (505 aa) | ||||
APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa) | ||||
APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa) | ||||
SREBF1 | Sterol regulatory element binding transcription factor 1. (1147 aa) | ||||
KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (770 aa) | ||||
POU1F1 | POU domain protein. (291 aa) | ||||
FOXK2 | Forkhead box K2. (658 aa) | ||||
C1QTNF1 | C1q and TNF related 1. (279 aa) | ||||
TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) | ||||
MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa) | ||||
FMO3 | Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa) | ||||
SLC4A1 | Anion exchange protein. (911 aa) | ||||
C1QTNF12 | C1q and TNF related 12. (297 aa) | ||||
HIF1A | Hypoxia inducible factor 1 subunit alpha. (825 aa) | ||||
AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) | ||||
PRXL2C | Peroxiredoxin like 2C. (232 aa) | ||||
SLC7A11 | Solute carrier family 7 member 11. (503 aa) | ||||
ABCD1 | ATP binding cassette subfamily D member 1. (733 aa) | ||||
LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (625 aa) | ||||
KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa) | ||||
MID1IP1 | MID1 interacting protein 1. (183 aa) | ||||
BMP5 | Bone morphogenetic protein 5. (454 aa) | ||||
SEC14L5 | SEC14 like lipid binding 5. (694 aa) | ||||
MLXIPL | MLX interacting protein like. (857 aa) | ||||
AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) | ||||
EP300 | E1A binding protein p300. (2425 aa) | ||||
LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (882 aa) | ||||
PPARA | Peroxisome proliferator activated receptor alpha. (468 aa) | ||||
WDR5 | WD repeat domain 5. (334 aa) | ||||
ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) | ||||
PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) | ||||
GFI1 | Growth factor independent 1 transcriptional repressor. (422 aa) | ||||
M3W534_FELCA | Uncharacterized protein. (56 aa) | ||||
GUCA2A | Guanylate cyclase activator 2A. (111 aa) | ||||
EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa) | ||||
NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) | ||||
AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa) | ||||
KCNMA1 | Potassium calcium-activated channel subfamily M alpha 1. (1288 aa) | ||||
CLCN2 | Chloride channel protein. (903 aa) | ||||
CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa) | ||||
DUSP12 | Dual specificity phosphatase 12. (353 aa) | ||||
C1QTNF6 | C1q and TNF related 6. (284 aa) | ||||
LOC101086441 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) | ||||
BEND3 | BEN domain containing 3. (828 aa) | ||||
GIP | GLUCAGON domain-containing protein. (222 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) | ||||
NR1H2 | Nuclear receptor subfamily 1 group H member 2. (457 aa) | ||||
LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa) | ||||
FBP1 | Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa) | ||||
GPD1 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa) | ||||
PDK2 | Protein-serine/threonine kinase. (407 aa) | ||||
GNMT | Glycine N-methyltransferase. (295 aa) | ||||
SNAI1 | Snail family transcriptional repressor 1. (264 aa) | ||||
GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (873 aa) | ||||
DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) | ||||
SEC14L2 | Uncharacterized protein. (403 aa) | ||||
NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) | ||||
P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa) | ||||
FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (565 aa) | ||||
DGKQ | Diacylglycerol kinase. (942 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa) | ||||
NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa) | ||||
GUCA1A | Guanylate cyclase activator 1A. (275 aa) | ||||
CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa) | ||||
ADIPOQ | Adiponectin, C1Q and collagen domain containing. (283 aa) | ||||
GCK | Phosphotransferase. (466 aa) | ||||
TTC39A | Tetratricopeptide repeat domain 39A. (656 aa) | ||||
CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) | ||||
SCAP | SREBF chaperone. (1278 aa) | ||||
ERLIN2 | ER lipid raft associated 2. (337 aa) | ||||
SNAI2 | Uncharacterized protein. (268 aa) | ||||
FGFR4 | Fibroblast growth factor receptor. (830 aa) | ||||
PLIN5 | Perilipin; Belongs to the perilipin family. (460 aa) | ||||
TFF3 | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (80 aa) | ||||
PROX1 | Prospero homeobox 1. (737 aa) | ||||
DKKL1 | Dickkopf like acrosomal protein 1. (242 aa) | ||||
ZBTB20 | Zinc finger and BTB domain containing 20. (741 aa) | ||||
PDK4 | Protein-serine/threonine kinase. (412 aa) | ||||
RUSC1 | RUN and SH3 domain containing 1. (907 aa) | ||||
FAM3C | Family with sequence similarity 3 member C. (227 aa) | ||||
LOC101096974 | Uncharacterized protein. (588 aa) | ||||
DDIT4 | DNA damage inducible transcript 4. (231 aa) | ||||
NCOA2 | Nuclear receptor coactivator. (1470 aa) | ||||
M3WWR9_FELCA | Dimethylaniline monooxygenase [N-oxide-forming]. (510 aa) | ||||
PRMT3 | Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa) | ||||
PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) | ||||
PARK7 | Parkinsonism associated deglycase. (189 aa) | ||||
TREX1 | Three prime repair exonuclease 1. (314 aa) | ||||
SLC7A7 | Solute carrier family 7 member 7. (511 aa) | ||||
C1QTNF3 | C1q domain-containing protein. (319 aa) | ||||
ABCD2 | ATP binding cassette subfamily D member 2. (739 aa) | ||||
EPM2AIP1 | EPM2A interacting protein 1. (608 aa) | ||||
PPTC7 | Protein phosphatase; Belongs to the PP2C family. (305 aa) | ||||
APOB | Apolipoprotein B. (4441 aa) | ||||
H6PD | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (825 aa) | ||||
SEC14L3 | SEC14 like lipid binding 3. (400 aa) | ||||
NCOR2 | Nuclear receptor corepressor 2. (2458 aa) | ||||
DDB1 | Damage specific DNA binding protein 1. (1140 aa) | ||||
BMP6 | Bone morphogenetic protein 6. (502 aa) | ||||
PDK1 | Protein-serine/threonine kinase. (449 aa) | ||||
CRY1 | Cryptochrome circadian regulator 1. (587 aa) | ||||
ACADM | Acyl-CoA dehydrogenase medium chain. (445 aa) | ||||
ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase. (227 aa) | ||||
SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa) | ||||
HTR2A | 5-hydroxytryptamine receptor 2A. (470 aa) | ||||
P2RY6 | Pyrimidinergic receptor P2Y6. (386 aa) | ||||
PPARD | Peroxisome proliferator activated receptor delta. (464 aa) | ||||
SIRT1 | Sirtuin 1. (745 aa) | ||||
EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa) | ||||
MALRD1 | MAM and LDL receptor class A domain containing 1. (2073 aa) | ||||
CLYBL | Citrate lyase beta like. (340 aa) | ||||
CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) | ||||
MST1 | Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa) | ||||
OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa) | ||||
CLN3 | Battenin. (438 aa) | ||||
ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa) | ||||
INSR | Tyrosine-protein kinase receptor. (1381 aa) | ||||
GIT1 | GIT ArfGAP 1. (770 aa) | ||||
BMP2 | Bone morphogenetic protein 2. (395 aa) | ||||
PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa) | ||||
STARD4 | StAR related lipid transfer domain containing 4. (208 aa) | ||||
DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30. (226 aa) | ||||
MFSD2A | Major facilitator superfamily domain containing 2A. (529 aa) | ||||
ETFBKMT | Electron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa) | ||||
LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) | ||||
PANK2 | Pantothenate kinase 2. (570 aa) | ||||
NCOR1 | Nuclear receptor corepressor 1. (2515 aa) | ||||
FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa) | ||||
USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa) | ||||
PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) | ||||
RD3 | Uncharacterized protein. (197 aa) | ||||
ARL2 | ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa) | ||||
PGP | Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (322 aa) | ||||
HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa) | ||||
TRIB3 | Tribbles pseudokinase 3. (357 aa) | ||||
COX11 | Cytochrome c oxidase copper chaperone COX11. (275 aa) | ||||
NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa) | ||||
LPGAT1 | Lysophosphatidylglycerol acyltransferase 1. (370 aa) | ||||
RANBP2 | RAN binding protein 2. (3043 aa) | ||||
FOXO1 | Forkhead box O1. (662 aa) | ||||
FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) | ||||
ELK4 | Solute carrier family 45 member 3. (564 aa) | ||||
LEPR | Leptin receptor. (1166 aa) | ||||
IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) | ||||
RORA | RAR related orphan receptor A. (523 aa) | ||||
ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) | ||||
ARV1 | ARV1 homolog, fatty acid homeostasis modulator. (283 aa) | ||||
FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) | ||||
MLYCD | Malonyl-CoA decarboxylase. (496 aa) | ||||
INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa) | ||||
NKX1-1 | NK1 homeobox 1. (409 aa) | ||||
REST | RE1 silencing transcription factor. (1045 aa) | ||||
IGF1 | Insulin like growth factor 1. (195 aa) | ||||
PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa) | ||||
LOC102900324 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (240 aa) | ||||
SLC35B4 | Solute carrier family 35 member B4. (331 aa) | ||||
FLCN | Uncharacterized protein. (579 aa) | ||||
LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (314 aa) | ||||
PDK3 | Protein-serine/threonine kinase. (415 aa) | ||||
SPHK2 | DAGKc domain-containing protein. (660 aa) | ||||
GUCA1B | Guanylate cyclase activator 1B. (201 aa) | ||||
PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa) | ||||
ATCAY | ATCAY kinesin light chain interacting caytaxin. (370 aa) | ||||
FAM3A | Family with sequence similarity 3 member A. (364 aa) | ||||
PTPN2 | Tyrosine-protein phosphatase non-receptor type. (416 aa) | ||||
ACTN3 | Actinin alpha 3 (gene/pseudogene). (933 aa) | ||||
GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) | ||||
PID1 | Phosphotyrosine interaction domain containing 1. (252 aa) | ||||
SLC2A6 | Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa) | ||||
BCKDK | Protein-serine/threonine kinase. (412 aa) | ||||
ENSFCAP00000044386 | Uncharacterized protein. (156 aa) | ||||
TTC39B | Tetratricopeptide repeat domain 39B. (712 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) | ||||
FMO5 | Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa) | ||||
SOX9 | SRY-box transcription factor 9. (511 aa) | ||||
TYSND1 | Trypsin domain containing 1. (648 aa) | ||||
LACC1 | Uncharacterized protein. (429 aa) | ||||
IGFBP3 | Insulin like growth factor binding protein 3. (299 aa) | ||||
FMO1 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) | ||||
MIDN | Midnolin. (510 aa) | ||||
BAD | BCL2 associated agonist of cell death. (273 aa) | ||||
ACADVL | Acyl-CoA dehydrogenase very long chain. (655 aa) | ||||
PLA2G3 | Phospholipase A2 group III. (522 aa) | ||||
CSN1S1 | Casein alpha s1. (183 aa) | ||||
ERFE | Erythroferrone. (343 aa) | ||||
PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) | ||||
TIGAR | TP53 induced glycolysis regulatory phosphatase. (428 aa) | ||||
SIRT6 | Sirtuin 6. (412 aa) | ||||
LDLR | Low density lipoprotein receptor. (866 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) | ||||
TSPO | Uncharacterized protein. (257 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) | ||||
FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa) | ||||
NR1H3 | Nuclear receptor subfamily 1 group H member 3. (498 aa) | ||||
NR1D1 | Nuclear receptor subfamily 1 group D member 1. (625 aa) | ||||
ABCB11 | ATP binding cassette subfamily B member 11. (1339 aa) | ||||
ENSFCAP00000053190 | DUF4371 domain-containing protein. (595 aa) | ||||
CBFA2T3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (758 aa) | ||||
FABP5 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (184 aa) | ||||
ANKRD26 | ANK_REP_REGION domain-containing protein. (266 aa) | ||||
PPARGC1A | PPARG coactivator 1 alpha. (803 aa) | ||||
SIRT4 | Sirtuin 4. (335 aa) | ||||
GUCA1C | Guanylate cyclase activator 1C. (210 aa) | ||||
ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (343 aa) | ||||
SEC14L4 | SEC14 like lipid binding 4. (451 aa) | ||||
ENSFCAP00000055954 | Uncharacterized protein. (133 aa) | ||||
SIRT7 | Sirtuin 7. (461 aa) | ||||
SERPINA12 | Serpin family A member 12; Belongs to the serpin family. (451 aa) | ||||
NCS1 | Neuronal calcium sensor 1. (261 aa) | ||||
INSIG2 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa) | ||||
GUCA2B | Guanylate cyclase activator 2B. (202 aa) | ||||
LOC102900614 | Uncharacterized protein. (594 aa) | ||||
APOA4 | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (452 aa) | ||||
SLC27A4 | Solute carrier family 27 member 4. (691 aa) | ||||
AKT2 | Non-specific serine/threonine protein kinase. (571 aa) | ||||
PIBF1 | Progesterone immunomodulatory binding factor 1. (696 aa) | ||||
ZNF692 | Zinc finger protein 692. (519 aa) | ||||
ANXA1 | Annexin. (407 aa) | ||||
WDTC1 | WD and tetratricopeptide repeats 1. (700 aa) | ||||
DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (467 aa) |