STRINGSTRING
SIK1 SIK1 ELOVL5 ELOVL5 ABCG4 ABCG4 PDZD3 PDZD3 APPL2 APPL2 APP APP SREBF1 SREBF1 KAT2A KAT2A STAT3 STAT3 POU1F1 POU1F1 FOXK2 FOXK2 C1QTNF1 C1QTNF1 TREM2 TREM2 MAS1 MAS1 FMO3 FMO3 SLC4A1 SLC4A1 C1QTNF12 C1QTNF12 HIF1A HIF1A AKT3 AKT3 PRXL2C PRXL2C SLC7A11 SLC7A11 ABCD1 ABCD1 LPCAT3 LPCAT3 KAT2B KAT2B MID1IP1 MID1IP1 BMP5 BMP5 SEC14L5 SEC14L5 MLXIPL MLXIPL AKT1 AKT1 EP300 EP300 LONP2 LONP2 PPARA PPARA WDR5 WDR5 ZMPSTE24 ZMPSTE24 PARP1 PARP1 IL1B IL1B GFI1 GFI1 M3W534_FELCA M3W534_FELCA GUCA2A GUCA2A EIF6 EIF6 NR1H4 NR1H4 AVPR1B AVPR1B KCNMA1 KCNMA1 CLCN2 CLCN2 CYP7A1 CYP7A1 DUSP12 DUSP12 C1QTNF6 C1QTNF6 LOC101086441 LOC101086441 BEND3 BEND3 GIP GIP IFNG IFNG NR1H2 NR1H2 LHCGR LHCGR FBP1 FBP1 GPD1 GPD1 PDK2 PDK2 GNMT GNMT SNAI1 SNAI1 GPLD1 GPLD1 DYRK2 DYRK2 SEC14L2 SEC14L2 NUPR1 NUPR1 P2RX7 P2RX7 FMO4 FMO4 DGKQ DGKQ BRCA1 BRCA1 NOS3 NOS3 GUCA1A GUCA1A CYP27C1 CYP27C1 ADIPOQ ADIPOQ GCK GCK TTC39A TTC39A CYP27B1 CYP27B1 SCAP SCAP ERLIN2 ERLIN2 SNAI2 SNAI2 FGFR4 FGFR4 PLIN5 PLIN5 TFF3 TFF3 PROX1 PROX1 DKKL1 DKKL1 ZBTB20 ZBTB20 PDK4 PDK4 RUSC1 RUSC1 FAM3C FAM3C LOC101096974 LOC101096974 DDIT4 DDIT4 NCOA2 NCOA2 M3WWR9_FELCA M3WWR9_FELCA PRMT3 PRMT3 PTK2B PTK2B PARK7 PARK7 TREX1 TREX1 SLC7A7 SLC7A7 C1QTNF3 C1QTNF3 ABCD2 ABCD2 EPM2AIP1 EPM2AIP1 PPTC7 PPTC7 APOB APOB H6PD H6PD SEC14L3 SEC14L3 NCOR2 NCOR2 DDB1 DDB1 BMP6 BMP6 PDK1 PDK1 CRY1 CRY1 ACADM ACADM ATPSCKMT ATPSCKMT SIRT5 SIRT5 HTR2A HTR2A P2RY6 P2RY6 PPARD PPARD SIRT1 SIRT1 EGR1 EGR1 MALRD1 MALRD1 CLYBL CLYBL CAV1 CAV1 MST1 MST1 OGT OGT CLN3 CLN3 ATP2B4 ATP2B4 INSR INSR GIT1 GIT1 BMP2 BMP2 PRKAG2 PRKAG2 STARD4 STARD4 DNAJC30 DNAJC30 MFSD2A MFSD2A ETFBKMT ETFBKMT LEP LEP PANK2 PANK2 NCOR1 NCOR1 FMO2 FMO2 USP7 USP7 PRKCE PRKCE RD3 RD3 ARL2 ARL2 PGP PGP HDAC4 HDAC4 TRIB3 TRIB3 COX11 COX11 NOS2 NOS2 LPGAT1 LPGAT1 RANBP2 RANBP2 FOXO1 FOXO1 FGF19 FGF19 ELK4 ELK4 LEPR LEPR IGFBP4 IGFBP4 RORA RORA ZBTB7A ZBTB7A ARV1 ARV1 FIS1 FIS1 MLYCD MLYCD INSIG1 INSIG1 NKX1-1 NKX1-1 REST REST IGF1 IGF1 PTH PTH LOC102900324 LOC102900324 SLC35B4 SLC35B4 FLCN FLCN LCMT1 LCMT1 PDK3 PDK3 SPHK2 SPHK2 GUCA1B GUCA1B PRKN PRKN ATCAY ATCAY FAM3A FAM3A PTPN2 PTPN2 ACTN3 ACTN3 GPER1 GPER1 PID1 PID1 SLC2A6 SLC2A6 BCKDK BCKDK ENSFCAP00000044386 ENSFCAP00000044386 TTC39B TTC39B TP53 TP53 FMO5 FMO5 SOX9 SOX9 TYSND1 TYSND1 LACC1 LACC1 IGFBP3 IGFBP3 FMO1 FMO1 MIDN MIDN BAD BAD ACADVL ACADVL PLA2G3 PLA2G3 CSN1S1 CSN1S1 ERFE ERFE PMAIP1 PMAIP1 TIGAR TIGAR SIRT6 SIRT6 LDLR LDLR PPARG PPARG TSPO TSPO TNF TNF FGF1 FGF1 NR1H3 NR1H3 NR1D1 NR1D1 ABCB11 ABCB11 ENSFCAP00000053190 ENSFCAP00000053190 CBFA2T3 CBFA2T3 FABP5 FABP5 ANKRD26 ANKRD26 PPARGC1A PPARGC1A SIRT4 SIRT4 GUCA1C GUCA1C ACMSD ACMSD SEC14L4 SEC14L4 ENSFCAP00000055954 ENSFCAP00000055954 SIRT7 SIRT7 SERPINA12 SERPINA12 NCS1 NCS1 INSIG2 INSIG2 GUCA2B GUCA2B LOC102900614 LOC102900614 APOA4 APOA4 SLC27A4 SLC27A4 AKT2 AKT2 PIBF1 PIBF1 ZNF692 ZNF692 ANXA1 ANXA1 WDTC1 WDTC1 DKK3 DKK3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIK1Uncharacterized protein. (780 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
ABCG4ATP binding cassette subfamily G member 4. (673 aa)
PDZD3PDZ domain containing 3. (505 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
POU1F1POU domain protein. (291 aa)
FOXK2Forkhead box K2. (658 aa)
C1QTNF1C1q and TNF related 1. (279 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
SLC4A1Anion exchange protein. (911 aa)
C1QTNF12C1q and TNF related 12. (297 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRXL2CPeroxiredoxin like 2C. (232 aa)
SLC7A11Solute carrier family 7 member 11. (503 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (625 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SEC14L5SEC14 like lipid binding 5. (694 aa)
MLXIPLMLX interacting protein like. (857 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EP300E1A binding protein p300. (2425 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (882 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
WDR5WD repeat domain 5. (334 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
M3W534_FELCAUncharacterized protein. (56 aa)
GUCA2AGuanylate cyclase activator 2A. (111 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1288 aa)
CLCN2Chloride channel protein. (903 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
DUSP12Dual specificity phosphatase 12. (353 aa)
C1QTNF6C1q and TNF related 6. (284 aa)
LOC101086441Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
BEND3BEN domain containing 3. (828 aa)
GIPGLUCAGON domain-containing protein. (222 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
GNMTGlycine N-methyltransferase. (295 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (873 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
SEC14L2Uncharacterized protein. (403 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (565 aa)
DGKQDiacylglycerol kinase. (942 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
GUCA1AGuanylate cyclase activator 1A. (275 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
GCKPhosphotransferase. (466 aa)
TTC39ATetratricopeptide repeat domain 39A. (656 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
SCAPSREBF chaperone. (1278 aa)
ERLIN2ER lipid raft associated 2. (337 aa)
SNAI2Uncharacterized protein. (268 aa)
FGFR4Fibroblast growth factor receptor. (830 aa)
PLIN5Perilipin; Belongs to the perilipin family. (460 aa)
TFF3Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (80 aa)
PROX1Prospero homeobox 1. (737 aa)
DKKL1Dickkopf like acrosomal protein 1. (242 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
RUSC1RUN and SH3 domain containing 1. (907 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
LOC101096974Uncharacterized protein. (588 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
NCOA2Nuclear receptor coactivator. (1470 aa)
M3WWR9_FELCADimethylaniline monooxygenase [N-oxide-forming]. (510 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
SLC7A7Solute carrier family 7 member 7. (511 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
ABCD2ATP binding cassette subfamily D member 2. (739 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (305 aa)
APOBApolipoprotein B. (4441 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (825 aa)
SEC14L3SEC14 like lipid binding 3. (400 aa)
NCOR2Nuclear receptor corepressor 2. (2458 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
PDK1Protein-serine/threonine kinase. (449 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (445 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (227 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
P2RY6Pyrimidinergic receptor P2Y6. (386 aa)
PPARDPeroxisome proliferator activated receptor delta. (464 aa)
SIRT1Sirtuin 1. (745 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
MALRD1MAM and LDL receptor class A domain containing 1. (2073 aa)
CLYBLCitrate lyase beta like. (340 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
CLN3Battenin. (438 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
GIT1GIT ArfGAP 1. (770 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
STARD4StAR related lipid transfer domain containing 4. (208 aa)
DNAJC30DnaJ heat shock protein family (Hsp40) member C30. (226 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (529 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PANK2Pantothenate kinase 2. (570 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RD3Uncharacterized protein. (197 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (322 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (275 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
RANBP2RAN binding protein 2. (3043 aa)
FOXO1Forkhead box O1. (662 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
ELK4Solute carrier family 45 member 3. (564 aa)
LEPRLeptin receptor. (1166 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
RORARAR related orphan receptor A. (523 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (283 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
MLYCDMalonyl-CoA decarboxylase. (496 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa)
NKX1-1NK1 homeobox 1. (409 aa)
RESTRE1 silencing transcription factor. (1045 aa)
IGF1Insulin like growth factor 1. (195 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
LOC102900324Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (240 aa)
SLC35B4Solute carrier family 35 member B4. (331 aa)
FLCNUncharacterized protein. (579 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (314 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
SPHK2DAGKc domain-containing protein. (660 aa)
GUCA1BGuanylate cyclase activator 1B. (201 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
ATCAYATCAY kinesin light chain interacting caytaxin. (370 aa)
FAM3AFamily with sequence similarity 3 member A. (364 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (933 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PID1Phosphotyrosine interaction domain containing 1. (252 aa)
SLC2A6Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
TTC39BTetratricopeptide repeat domain 39B. (712 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa)
SOX9SRY-box transcription factor 9. (511 aa)
TYSND1Trypsin domain containing 1. (648 aa)
LACC1Uncharacterized protein. (429 aa)
IGFBP3Insulin like growth factor binding protein 3. (299 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
MIDNMidnolin. (510 aa)
BADBCL2 associated agonist of cell death. (273 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
CSN1S1Casein alpha s1. (183 aa)
ERFEErythroferrone. (343 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
SIRT6Sirtuin 6. (412 aa)
LDLRLow density lipoprotein receptor. (866 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TSPOUncharacterized protein. (257 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (498 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (625 aa)
ABCB11ATP binding cassette subfamily B member 11. (1339 aa)
ENSFCAP00000053190DUF4371 domain-containing protein. (595 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (758 aa)
FABP5Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (184 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
SIRT4Sirtuin 4. (335 aa)
GUCA1CGuanylate cyclase activator 1C. (210 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (343 aa)
SEC14L4SEC14 like lipid binding 4. (451 aa)
ENSFCAP00000055954Uncharacterized protein. (133 aa)
SIRT7Sirtuin 7. (461 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (451 aa)
NCS1Neuronal calcium sensor 1. (261 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
GUCA2BGuanylate cyclase activator 2B. (202 aa)
LOC102900614Uncharacterized protein. (594 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (452 aa)
SLC27A4Solute carrier family 27 member 4. (691 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (696 aa)
ZNF692Zinc finger protein 692. (519 aa)
ANXA1Annexin. (407 aa)
WDTC1WD and tetratricopeptide repeats 1. (700 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (467 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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