STRINGSTRING
ELOVL5 ELOVL5 ABCG4 ABCG4 APP APP SREBF1 SREBF1 KAT2A KAT2A POU1F1 POU1F1 TREM2 TREM2 MAS1 MAS1 AKT3 AKT3 PRXL2C PRXL2C ABCD1 ABCD1 KAT2B KAT2B MID1IP1 MID1IP1 MLXIPL MLXIPL AKT1 AKT1 PPARA PPARA WDR5 WDR5 IL1B IL1B M3W534_FELCA M3W534_FELCA GUCA2A GUCA2A NR1H4 NR1H4 AVPR1B AVPR1B BEND3 BEND3 IFNG IFNG NR1H2 NR1H2 LHCGR LHCGR GPD1 GPD1 GPLD1 GPLD1 DYRK2 DYRK2 P2RX7 P2RX7 NOS3 NOS3 GUCA1A GUCA1A ADIPOQ ADIPOQ GCK GCK SCAP SCAP PLIN5 PLIN5 ZBTB20 ZBTB20 RUSC1 RUSC1 PARK7 PARK7 ABCD2 ABCD2 EPM2AIP1 EPM2AIP1 DDB1 DDB1 BMP6 BMP6 HTR2A HTR2A P2RY6 P2RY6 PPARD PPARD SIRT1 SIRT1 CLYBL CLYBL INSR INSR STARD4 STARD4 PRKCE PRKCE NOS2 NOS2 LPGAT1 LPGAT1 FOXO1 FOXO1 ELK4 ELK4 MLYCD MLYCD IGF1 IGF1 PTH PTH GUCA1B GUCA1B PTPN2 PTPN2 ACTN3 ACTN3 GPER1 GPER1 PID1 PID1 ENSFCAP00000044386 ENSFCAP00000044386 PLA2G3 PLA2G3 CSN1S1 CSN1S1 PMAIP1 PMAIP1 PPARG PPARG TNF TNF FGF1 FGF1 NR1H3 NR1H3 NR1D1 NR1D1 ENSFCAP00000053190 ENSFCAP00000053190 PPARGC1A PPARGC1A GUCA1C GUCA1C NCS1 NCS1 GUCA2B GUCA2B LOC102900614 LOC102900614 APOA4 APOA4 AKT2 AKT2 ANXA1 ANXA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
ABCG4ATP binding cassette subfamily G member 4. (673 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
POU1F1POU domain protein. (291 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRXL2CPeroxiredoxin like 2C. (232 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
MLXIPLMLX interacting protein like. (857 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
WDR5WD repeat domain 5. (334 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
M3W534_FELCAUncharacterized protein. (56 aa)
GUCA2AGuanylate cyclase activator 2A. (111 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
BEND3BEN domain containing 3. (828 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (873 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
GUCA1AGuanylate cyclase activator 1A. (275 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
GCKPhosphotransferase. (466 aa)
SCAPSREBF chaperone. (1278 aa)
PLIN5Perilipin; Belongs to the perilipin family. (460 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
RUSC1RUN and SH3 domain containing 1. (907 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
ABCD2ATP binding cassette subfamily D member 2. (739 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
P2RY6Pyrimidinergic receptor P2Y6. (386 aa)
PPARDPeroxisome proliferator activated receptor delta. (464 aa)
SIRT1Sirtuin 1. (745 aa)
CLYBLCitrate lyase beta like. (340 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
STARD4StAR related lipid transfer domain containing 4. (208 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
FOXO1Forkhead box O1. (662 aa)
ELK4Solute carrier family 45 member 3. (564 aa)
MLYCDMalonyl-CoA decarboxylase. (496 aa)
IGF1Insulin like growth factor 1. (195 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
GUCA1BGuanylate cyclase activator 1B. (201 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (933 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PID1Phosphotyrosine interaction domain containing 1. (252 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
CSN1S1Casein alpha s1. (183 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (498 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (625 aa)
ENSFCAP00000053190DUF4371 domain-containing protein. (595 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
GUCA1CGuanylate cyclase activator 1C. (210 aa)
NCS1Neuronal calcium sensor 1. (261 aa)
GUCA2BGuanylate cyclase activator 2B. (202 aa)
LOC102900614Uncharacterized protein. (594 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (452 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ANXA1Annexin. (407 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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