33 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	SOX9	SRY-box transcription factor 9. (511 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1630 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1014 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
	GRB10	Growth factor receptor bound protein 10. (594 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (804 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (362 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (503 aa)
	HESX1	HESX homeobox 1. (207 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (166 aa)
	KARS1	Lysine--tRNA ligase. (625 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1270 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	FLCN	Uncharacterized protein. (579 aa)
	C1QL4	Complement C1q like 4. (238 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (705 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	ANKRD26	ANK_REP_REGION domain-containing protein. (266 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (572 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1322 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	RAPGEF1	ENSFCAP00000004739	ENSFCAP00000038275	Tyrosine-protein kinase.	Rap guanine nucleotide exchange factor 1.	0.529
AVP	EDN1	ENSFCAP00000027829	ENSFCAP00000013767	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.497
BRAF	IQGAP3	ENSFCAP00000011915	ENSFCAP00000006085	B-Raf proto-oncogene, serine/threonine kinase.	IQ motif containing GTPase activating protein 3.	0.517
BRAF	MAPK1	ENSFCAP00000011915	ENSFCAP00000025541	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the PP2C family.	0.843
BRAF	MAPK3	ENSFCAP00000011915	ENSFCAP00000034399	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.841
BRAF	SPRY2	ENSFCAP00000011915	ENSFCAP00000007170	B-Raf proto-oncogene, serine/threonine kinase.	Sprouty RTK signaling antagonist 2.	0.944
EDN1	AVP	ENSFCAP00000013767	ENSFCAP00000027829	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	0.497
EDN1	KDR	ENSFCAP00000013767	ENSFCAP00000008977	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.548
FGF10	FGF18	ENSFCAP00000032796	ENSFCAP00000048240	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
FGF10	FGF23	ENSFCAP00000032796	ENSFCAP00000049106	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.676
FGF10	KDR	ENSFCAP00000032796	ENSFCAP00000008977	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.809
FGF10	SOX9	ENSFCAP00000032796	ENSFCAP00000045943	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.576
FGF10	SPRY2	ENSFCAP00000032796	ENSFCAP00000007170	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sprouty RTK signaling antagonist 2.	0.406
FGF18	FGF10	ENSFCAP00000048240	ENSFCAP00000032796	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
FGF18	FGF23	ENSFCAP00000048240	ENSFCAP00000049106	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.734
FGF18	KDR	ENSFCAP00000048240	ENSFCAP00000008977	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.814
FGF18	MAPK1	ENSFCAP00000048240	ENSFCAP00000025541	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mitogen-activated protein kinase; Belongs to the PP2C family.	0.403
FGF18	MAPK3	ENSFCAP00000048240	ENSFCAP00000034399	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.403
FGF18	SOX9	ENSFCAP00000048240	ENSFCAP00000045943	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.528
FGF23	FGF10	ENSFCAP00000049106	ENSFCAP00000032796	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.676