STRINGSTRING
FBXW7 FBXW7 PTPN6 PTPN6 PTPN22 PTPN22 CX3CL1 CX3CL1 CCL19 CCL19 ROS1 ROS1 TNFRSF11A TNFRSF11A ENSFCAP00000059689 ENSFCAP00000059689 TRAF7 TRAF7 ADCYAP1 ADCYAP1 HMGB1 HMGB1 VRK3 VRK3 PDGFC PDGFC PTPRC PTPRC ENSFCAP00000056245 ENSFCAP00000056245 ZDHHC17 ZDHHC17 WNK2 WNK2 RASGRP1 RASGRP1 EZR EZR PRKCZ PRKCZ GPR183 GPR183 ANKRD26 ANKRD26 CCN2 CCN2 THPO THPO TRPV4 TRPV4 PDGFD PDGFD ENSFCAP00000052225 ENSFCAP00000052225 C5AR2 C5AR2 DENND2B DENND2B FGF1 FGF1 BMP4 BMP4 CXCL17 CXCL17 PYCARD PYCARD DLG1 DLG1 ENSFCAP00000050587 ENSFCAP00000050587 SCIMP SCIMP FBLN1 FBLN1 C3orf33 C3orf33 FGF23 FGF23 DUSP3 DUSP3 DLG2 DLG2 PTPRR PTPRR DUSP26 DUSP26 SYNJ2BP SYNJ2BP CD44 CD44 FGF18 FGF18 ALKAL2 ALKAL2 MFHAS1 MFHAS1 RAPGEF2 RAPGEF2 ALKAL1 ALKAL1 FGFR3 FGFR3 GPER1 GPER1 HAND2 HAND2 PTPN2 PTPN2 C1QL4 C1QL4 FLCN FLCN ERBB4 ERBB4 EPHB1 EPHB1 PHB PHB CCL26 CCL26 C5AR1 C5AR1 CCL7 CCL7 GAREM2 GAREM2 EGFR EGFR RAMP3 RAMP3 LOC100302541 LOC100302541 SRC SRC NDRG4 NDRG4 FRS2 FRS2 FGF19 FGF19 TLR9 TLR9 NOD1 NOD1 RAPGEF1 RAPGEF1 CCL22 CCL22 CAVIN3 CAVIN3 RANBP9 RANBP9 DNAJC27 DNAJC27 LIF LIF MAPK3 MAPK3 SLC9A3R1 SLC9A3R1 LOC100302540 LOC100302540 NPNT NPNT PSCA PSCA FGF4 FGF4 FGF10 FGF10 FBXW9 FBXW9 EPHB2 EPHB2 CARD9 CARD9 SMAD4 SMAD4 ITGB1BP1 ITGB1BP1 BMP2 BMP2 APELA APELA CHI3L1 CHI3L1 CCL1 CCL1 PTPN11 PTPN11 ENSFCAP00000029786 ENSFCAP00000029786 TIMP3 TIMP3 HCRTR1 HCRTR1 GLIPR2 GLIPR2 DAB2IP DAB2IP HAVCR2 HAVCR2 OPRM1 OPRM1 STYX STYX P2RY6 P2RY6 HTR2A HTR2A SEMA6A SEMA6A ATF3 ATF3 NOX4 NOX4 GPR55 GPR55 CIB1 CIB1 TLR4 TLR4 FERMT2 FERMT2 PDGFA PDGFA DUSP4 DUSP4 ERBB2 ERBB2 CCL13 CCL13 LYN LYN RAP1A RAP1A PHB2 PHB2 LOC101081599 LOC101081599 JUN JUN RRAS RRAS NOTCH1 NOTCH1 EMILIN1 EMILIN1 CCL24 CCL24 PTK2B PTK2B CCN1 CCN1 NLRP6 NLRP6 YWHAZ YWHAZ GAREM1 GAREM1 HTR2B HTR2B RIPK2 RIPK2 PTEN PTEN CCL14 CCL14 FGFR4 FGFR4 PDGFB PDGFB SLC30A10 SLC30A10 DUSP10 DUSP10 NDRG2 NDRG2 SYK SYK MARCO MARCO ADIPOQ ADIPOQ CCL8 CCL8 SPRY1 SPRY1 FGB FGB TNIP1 TNIP1 BRAF BRAF MAP3K12 MAP3K12 ACKR3 ACKR3 SPRED1 SPRED1 PRKCA PRKCA TNIP3 TNIP3 IL26 IL26 PRKD2 PRKD2 EPHA2 EPHA2 CCL16 CCL16 FFAR4 FFAR4 KDR KDR NOTCH2 NOTCH2 PIN1 PIN1 PKHD1 PKHD1 FN1 FN1 PDGFRA PDGFRA NOD2 NOD2 SEMA7A SEMA7A SPRY2 SPRY2 EPHA4 EPHA4 FGF21 FGF21 GAS6 GAS6 DSTYK DSTYK NPTN NPTN SERPINF2 SERPINF2 CRKL CRKL TNFSF11 TNFSF11 IL1B IL1B DUPD1 DUPD1 TGFB1 TGFB1 ABL1 ABL1 PLA2G5 PLA2G5 CCL17 CCL17 AGER AGER CD4 CD4 DUSP9 DUSP9 PTPN1 PTPN1 SLAMF1 SLAMF1 PRXL2C PRXL2C SPRY4 SPRY4 PDGFRB PDGFRB CSF1R CSF1R CCL20 CCL20 F2R F2R CCL21 CCL21 NEK10 NEK10 TEK TEK TREM2 TREM2 APIP APIP FLT4 FLT4 APP APP SHC1 SHC1 CCL5 CCL5 NODAL NODAL FSHR FSHR BMPER BMPER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXW7F-box and WD repeat domain containing 7. (749 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (449 aa)
CCL19C-C motif chemokine. (115 aa)
ROS1Tyrosine-protein kinase receptor. (2309 aa)
TNFRSF11ATNF receptor superfamily member 11a. (638 aa)
ENSFCAP00000059689Uncharacterized protein. (377 aa)
TRAF7TNF receptor associated factor 7. (825 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (318 aa)
HMGB1Uncharacterized protein. (233 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
ENSFCAP0000005624514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (178 aa)
ZDHHC17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (686 aa)
WNK2WNK lysine deficient protein kinase 2. (2159 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
EZREzrin. (639 aa)
PRKCZProtein kinase C zeta. (649 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
CCN2Cellular communication network factor 2. (477 aa)
THPOThrombopoietin. (409 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
ENSFCAP00000052225C-C motif chemokine. (80 aa)
C5AR2Complement component 5a receptor 2. (332 aa)
DENND2BSuppression of tumorigenicity 5. (1184 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
PYCARDPYD and CARD domain containing. (195 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
ENSFCAP00000050587SCY domain-containing protein. (157 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (143 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
C3orf33Chromosome 3 open reading frame 33. (301 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (655 aa)
DUSP26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
CD44CD44 molecule (Indian blood group). (741 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
ALKAL2Uncharacterized protein. (60 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1157 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1700 aa)
ALKAL1Uncharacterized protein. (283 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
HAND2Heart and neural crest derivatives expressed 2. (275 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
C1QL4Complement C1q like 4. (238 aa)
FLCNUncharacterized protein. (579 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
EPHB1EPH receptor B1. (984 aa)
PHBProhibitin. (272 aa)
CCL26C-C motif chemokine. (94 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CCL7C-C motif chemokine. (99 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (869 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RAMP3Receptor activity modifying protein 3. (150 aa)
LOC100302541C-C motif chemokine. (102 aa)
SRCTyrosine-protein kinase. (678 aa)
NDRG4NDRG family member 4. (424 aa)
FRS2Fibroblast growth factor receptor substrate 2. (543 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
CCL22C-C motif chemokine. (93 aa)
CAVIN3Uncharacterized protein. (261 aa)
RANBP9RAN binding protein 9. (725 aa)
DNAJC27DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
LOC100302540C-C motif chemokine. (93 aa)
NPNTNephronectin. (612 aa)
PSCAProstate stem cell antigen. (115 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
EPHB2EPH receptor B2. (899 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (213 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
APELAUncharacterized protein. (54 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
CCL1SCY domain-containing protein. (94 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENSFCAP00000029786Uncharacterized protein. (76 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
P2RY6Pyrimidinergic receptor P2Y6. (386 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
ATF3Activating transcription factor 3. (259 aa)
NOX4NADPH oxidase 4. (578 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
CIB1Calcium and integrin binding 1. (191 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
FERMT2Fermitin family member 2. (706 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ERBB2Receptor protein-tyrosine kinase. (1308 aa)
CCL13C-C motif chemokine. (98 aa)
LYNTyrosine-protein kinase. (526 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PHB2Prohibitin. (299 aa)
LOC101081599SCY domain-containing protein. (158 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RRASRAS related. (218 aa)
NOTCH1Notch receptor 1. (2543 aa)
EMILIN1Elastin microfibril interfacer 1. (1025 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
CCN1Cellular communication network factor 1. (382 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (876 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CCL14C-C motif chemokine. (95 aa)
FGFR4Fibroblast growth factor receptor. (830 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
SLC30A10Solute carrier family 30 member 10. (483 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
NDRG2NDRG family member 2. (394 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
MARCOMacrophage receptor with collagenous structure. (486 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
CCL8C-C motif chemokine. (99 aa)
SPRY1Sprouty RTK signaling antagonist 1. (362 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (473 aa)
TNIP1TNFAIP3 interacting protein 1. (635 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (406 aa)
SPRED1Sprouty related EVH1 domain containing 1. (443 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
TNIP3TNFAIP3 interacting protein 3. (397 aa)
IL26Interleukin 26. (171 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
EPHA2EPH receptor A2. (936 aa)
CCL16C-C motif chemokine. (107 aa)
FFAR4G protein coupled receptor 120 / free fatty acid receptor 4. (361 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
NOTCH2Notch receptor 2. (2493 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4078 aa)
FN1Fibronectin 1. (2475 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (769 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
EPHA4EPH receptor A4. (986 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GAS6Growth arrest specific 6. (674 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (929 aa)
NPTNNeuroplastin. (446 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (565 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
DUPD1Dual specificity phosphatase and pro isomerase domain containing 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (321 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
PLA2G5Phospholipase A(2). (158 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
CD4CD4 molecule. (487 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (380 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
PRXL2CPeroxiredoxin like 2C. (232 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
CCL20C-C motif chemokine. (97 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
NEK10NIMA related kinase 10. (1173 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
SHC1SHC adaptor protein 1. (566 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
NODALNodal growth differentiation factor. (348 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
BMPERBMP binding endothelial regulator. (685 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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