STRINGSTRING
SIRT6 SIRT6 HPGD HPGD EHHADH EHHADH CRYL1 CRYL1 UXS1 UXS1 ALDH1A3 ALDH1A3 HADHA HADHA PARP14 PARP14 SIRT5 SIRT5 SIRT1 SIRT1 PARP15 PARP15 SIRT4 SIRT4 SIRT7 SIRT7 SIRT2 SIRT2 SIRT3 SIRT3 HADH HADH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT6Sirtuin 6. (412 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (806 aa)
CRYL1Crystallin lambda 1. (318 aa)
UXS1UDP-glucuronate decarboxylase 1. (490 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
PARP14Poly [ADP-ribose] polymerase. (1802 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
SIRT1Sirtuin 1. (745 aa)
PARP15Poly [ADP-ribose] polymerase. (684 aa)
SIRT4Sirtuin 4. (335 aa)
SIRT7Sirtuin 7. (461 aa)
SIRT2Sirtuin 2. (497 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa)
HADHHydroxyacyl-CoA dehydrogenase. (338 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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