STRINGSTRING
TNIP2 TNIP2 STAP1 STAP1 HAVCR2 HAVCR2 DAB2IP DAB2IP GIT1 GIT1 ADAM9 ADAM9 TICAM2 TICAM2 CD14 CD14 CTR9 CTR9 MEF2C MEF2C SCARB1 SCARB1 LOC100302540 LOC100302540 MAPK3 MAPK3 PRKCE PRKCE AXL AXL MYD88 MYD88 CXCL11 CXCL11 ENSFCAP00000040772 ENSFCAP00000040772 IL1F10 IL1F10 XBP1 XBP1 PLCG2 PLCG2 ENSFCAP00000042577 ENSFCAP00000042577 CXCL10 CXCL10 LOC101094096 LOC101094096 ZFP36 ZFP36 TRAF6 TRAF6 CHMP5 CHMP5 PLSCR4 PLSCR4 ACOD1 ACOD1 RELA RELA LITAF LITAF ENSFCAP00000049367 ENSFCAP00000049367 VIM VIM IRF8 IRF8 BCL10 BCL10 PYCARD PYCARD TNF TNF MRC1 MRC1 PAF1 PAF1 NR1H3 NR1H3 NR1D1 NR1D1 CCR5 CCR5 CXCL13 CXCL13 IL36G IL36G ARID5A ARID5A LOC101094344 LOC101094344 SBNO2 SBNO2 NFKBIL1 NFKBIL1 TNFAIP3 TNFAIP3 TNFSF4 TNFSF4 UPF1 UPF1 CD86 CD86 LBP LBP LOC101093854 LOC101093854 PDE4B PDE4B KLRK1 KLRK1 LOC109498011 LOC109498011 CX3CR1 CX3CR1 NUGGC NUGGC NFKBIB NFKBIB TNFRSF1B TNFRSF1B CXCL8 CXCL8 CD180 CD180 BPI BPI ABL1 ABL1 TGFB1 TGFB1 IL1B IL1B GFI1 GFI1 IRF3 IRF3 NR1H4 NR1H4 NFKBIA NFKBIA CCDC142 CCDC142 SHPK SHPK IL1A IL1A NOD2 NOD2 FCAR FCAR ZC3H12A ZC3H12A CD274 CD274 PDCD1LG2 PDCD1LG2 CD80 CD80 BPIFC BPIFC IRAK1 IRAK1 PLSCR3 PLSCR3 TNIP3 TNIP3 IRAK2 IRAK2 PDCD4 PDCD4 PTAFR PTAFR TNIP1 TNIP1 CLEC17A CLEC17A IL10 IL10 CD6 CD6 MALT1 MALT1 HADHB HADHB CXCL6 CXCL6 ANKRD1 ANKRD1 RIPK2 RIPK2 BCR BCR LDOC1 LDOC1 LY96 LY96 CACTIN CACTIN LYN LYN IL6 IL6 SELENOS SELENOS TLR4 TLR4 CMPK2 CMPK2 PLAA PLAA MAPK1 MAPK1 IL36RN IL36RN IL12B IL12B IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNIP2TNFAIP3 interacting protein 2. (436 aa)
STAP1Signal transducing adaptor family member 1. (282 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
GIT1GIT ArfGAP 1. (770 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
LOC100302540C-C motif chemokine. (93 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
CXCL11C-X-C motif chemokine. (100 aa)
ENSFCAP00000040772G_PROTEIN_RECEP_F1_2 domain-containing protein. (224 aa)
IL1F10Interleukin-1. (152 aa)
XBP1X-box binding protein 1. (383 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
ENSFCAP00000042577DUF4939 domain-containing protein. (113 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC101094096C-X-C motif chemokine. (104 aa)
ZFP36ZFP36 ring finger protein. (513 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CHMP5Charged multivesicular body protein 5. (372 aa)
PLSCR4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (356 aa)
ACOD1Aconitate decarboxylase 1. (482 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
LITAFUncharacterized protein. (521 aa)
ENSFCAP00000049367annotation not available (113 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
IRF8Interferon regulatory factor 8. (427 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
MRC1Mannose receptor C-type 1. (1484 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (498 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (625 aa)
CCR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CXCL13C-X-C motif chemokine. (120 aa)
IL36GInterleukin-1. (219 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
LOC101094344C-X-C motif chemokine. (113 aa)
SBNO2Strawberry notch homolog 2. (1352 aa)
NFKBIL1NFKB inhibitor like 1. (455 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
UPF1UPF1 RNA helicase and ATPase. (1162 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
LBPLipopolysaccharide binding protein. (497 aa)
LOC101093854C-X-C motif chemokine. (96 aa)
PDE4BPhosphodiesterase. (737 aa)
KLRK1Killer cell lectin like receptor K1. (215 aa)
LOC109498011Uncharacterized protein. (483 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
NUGGCNuclear GTPase, germinal center associated. (794 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CD180CD180 molecule. (661 aa)
BPIBactericidal permeability increasing protein. (654 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
IRF3Interferon regulatory factor 3. (420 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CCDC142Coiled-coil domain containing 142. (785 aa)
SHPKFGGY_N domain-containing protein. (478 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
FCARIg domain-containing protein. (176 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
CD274CD274 molecule. (297 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (302 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
BPIFCBPI fold containing family C. (507 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
TNIP3TNFAIP3 interacting protein 3. (397 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (618 aa)
PDCD4Programmed cell death 4. (469 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
TNIP1TNFAIP3 interacting protein 1. (635 aa)
CLEC17AC-type lectin domain containing 17A. (367 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CD6CD6 molecule. (678 aa)
MALT1MALT1 paracaspase. (848 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
CXCL6C-X-C motif chemokine. (148 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
LY96Lymphocyte antigen 96. (160 aa)
CACTINCactin, spliceosome C complex subunit. (754 aa)
LYNTyrosine-protein kinase. (526 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
SELENOSSelenoprotein S. (188 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
CMPK2Cytidine/uridine monophosphate kinase 2. (442 aa)
PLAAPhospholipase A2 activating protein. (796 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
IL36RNInterleukin-1. (196 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.