STRINGSTRING
STXBP1 STXBP1 STAT1 STAT1 MRC1 MRC1 ACTR3B ACTR3B GSN GSN MYO1C MYO1C RAB7B RAB7B AIF1 AIF1 CD58 CD58 ENSFCAP00000060491 ENSFCAP00000060491 CCL19 CCL19 CX3CL1 CX3CL1 IL12RB1 IL12RB1 LOC101081599 LOC101081599 M3X4Q0_FELCA M3X4Q0_FELCA RPS6KB1 RPS6KB1 RAB20 RAB20 CCL13 CCL13 PDE12 PDE12 ZYX ZYX SLC26A6 SLC26A6 TLR4 TLR4 IL12B IL12B CDC42EP4 CDC42EP4 LOC100302540 LOC100302540 CCL22 CCL22 GBP1 GBP1 CCL24 CCL24 SYNCRIP SYNCRIP CCL5 CCL5 CDC42EP2 CDC42EP2 EPRS1 EPRS1 CCL21 CCL21 CCL20 CCL20 CCL17 CCL17 DAPK1 DAPK1 VAMP3 VAMP3 GAPDH GAPDH STX8 STX8 NMI NMI FCAR FCAR IFNG IFNG CCL16 CCL16 LOC101082677 LOC101082677 IRF1 IRF1 CLEC17A CLEC17A ACTR3 ACTR3 CCL8 CCL8 WAS WAS STXBP3 STXBP3 KIF5B KIF5B VPS26B VPS26B LOC100302541 LOC100302541 CCL26 CCL26 LOC111560445 LOC111560445 TP53 TP53 LOC101090771 LOC101090771 STXBP4 STXBP4 AQP4 AQP4 VIM VIM IRF8 IRF8 ENSFCAP00000050587 ENSFCAP00000050587
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
MRC1Mannose receptor C-type 1. (1484 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (522 aa)
GSNGelsolin. (815 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1074 aa)
RAB7BRAB7B, member RAS oncogene family. (297 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
CD58Uncharacterized protein. (270 aa)
ENSFCAP00000060491Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (308 aa)
CCL19C-C motif chemokine. (115 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (449 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
LOC101081599SCY domain-containing protein. (158 aa)
M3X4Q0_FELCAGp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (215 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
CCL13C-C motif chemokine. (98 aa)
PDE12Phosphodiesterase 12. (608 aa)
ZYXZyxin. (913 aa)
SLC26A6Solute carrier family 26 member 6. (756 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
CDC42EP4CDC42 effector protein 4. (279 aa)
LOC100302540C-C motif chemokine. (93 aa)
CCL22C-C motif chemokine. (93 aa)
GBP1Guanylate binding protein 1. (591 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (623 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1576 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
CCL20C-C motif chemokine. (97 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
DAPK1Death associated protein kinase 1. (1429 aa)
VAMP3Vesicle associated membrane protein 3. (103 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
STX8Syntaxin 8. (283 aa)
NMIN-myc and STAT interactor. (309 aa)
FCARIg domain-containing protein. (176 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
CCL16C-C motif chemokine. (107 aa)
LOC101082677GB1/RHD3-type G domain-containing protein. (693 aa)
IRF1Interferon regulatory factor. (322 aa)
CLEC17AC-type lectin domain containing 17A. (367 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
CCL8C-C motif chemokine. (99 aa)
WASWASP actin nucleation promoting factor. (501 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
VPS26BVPS26, retromer complex component B. (338 aa)
LOC100302541C-C motif chemokine. (102 aa)
CCL26C-C motif chemokine. (94 aa)
LOC111560445Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
STXBP4Uncharacterized protein. (562 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
IRF8Interferon regulatory factor 8. (427 aa)
ENSFCAP00000050587SCY domain-containing protein. (157 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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