STRINGSTRING
CD70 CD70 KRT18 KRT18 TRAF2 TRAF2 GBA GBA CARD14 CARD14 CCL5 CCL5 CLDN18 CLDN18 SLC2A4 SLC2A4 CCL21 CCL21 CCL20 CCL20 TNFRSF1B TNFRSF1B CXCL8 CXCL8 CCL17 CCL17 MYOD1 MYOD1 TNFSF11 TNFSF11 NFKBIA NFKBIA TNFRSF1A TNFRSF1A HYAL2 HYAL2 FCAR FCAR ZC3H12A ZC3H12A DCSTAMP DCSTAMP GPD1 GPD1 CCL16 CCL16 M3WCQ5_FELCA M3WCQ5_FELCA M3WDH2_FELCA M3WDH2_FELCA EDA2R EDA2R RPS3 RPS3 NFE2L2 NFE2L2 ZFAND6 ZFAND6 CCL8 CCL8 RIPK1 RIPK1 ILK ILK ANKRD1 ANKRD1 CCL14 CCL14 DHX9 DHX9 YBX3 YBX3 FABP4 FABP4 TXNDC17 TXNDC17 PTK2B PTK2B CCL24 CCL24 LOC101081599 LOC101081599 CACTIN CACTIN TNFSF13B TNFSF13B CCL13 CCL13 FOXO3 FOXO3 CDIP1 CDIP1 ZFP36L1 ZFP36L1 CIB1 CIB1 CRHBP CRHBP MAPK1 MAPK1 FAS FAS ACTN4 ACTN4 SIRT1 SIRT1 TRAF5 TRAF5 DAB2IP DAB2IP GSDME GSDME CCL1 CCL1 ENSFCAP00000030239 ENSFCAP00000030239 ENSFCAP00000030418 ENSFCAP00000030418 CHI3L1 CHI3L1 ENSFCAP00000031202 ENSFCAP00000031202 OCSTAMP OCSTAMP HAS2 HAS2 TANK TANK ARHGEF2 ARHGEF2 NPNT NPNT LOC100302540 LOC100302540 MAPK3 MAPK3 TNFRSF21 TNFRSF21 SFRP1 SFRP1 TRAF3 TRAF3 CCL22 CCL22 LOC101081091 LOC101081091 RORA RORA LOC100302541 LOC100302541 CCL7 CCL7 CCL26 CCL26 BAG4 BAG4 HYAL3 HYAL3 TNFSF18 TNFSF18 GPER1 GPER1 PID1 PID1 TNFRSF17 TNFRSF17 EXT1 EXT1 GATA3 GATA3 IKBKB IKBKB TMEM130 TMEM130 TRADD TRADD TP53 TP53 ERBIN ERBIN ZFP36L2 ZFP36L2 ENSFCAP00000046520 ENSFCAP00000046520 ZFP36 ZFP36 TRAF6 TRAF6 RELA RELA PIAS3 PIAS3 ADAMTS12 ADAMTS12 ENSFCAP00000050587 ENSFCAP00000050587 STAT1 STAT1 PYCARD PYCARD TNF TNF TRAF3IP2 TRAF3IP2 ADAMTS7 ADAMTS7 COMMD7 COMMD7 TRAF1 TRAF1 NR1D1 NR1D1 LOC101090625 LOC101090625 ENSFCAP00000052225 ENSFCAP00000052225 LRRC7 LRRC7 NKX3-1 NKX3-1 TNFRSF13C TNFRSF13C ENSFCAP00000055090 ENSFCAP00000055090 ENSFCAP00000057420 ENSFCAP00000057420 TNFRSF11A TNFRSF11A ENSFCAP00000059874 ENSFCAP00000059874 INPP5K INPP5K CD58 CD58 TNFRSF4 TNFRSF4 SMPD4 SMPD4 CHUK CHUK SMPD3 SMPD3 CCL19 CCL19 CX3CL1 CX3CL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD70CD70 molecule; Belongs to the tumor necrosis factor family. (190 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
GBAGlucosylceramidase. (536 aa)
CARD14Caspase recruitment domain family member 14. (969 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
CCL20C-C motif chemokine. (97 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
HYAL2Hyaluronidase. (780 aa)
FCARIg domain-containing protein. (176 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
CCL16C-C motif chemokine. (107 aa)
M3WCQ5_FELCAUncharacterized protein. (151 aa)
M3WDH2_FELCAUncharacterized protein. (157 aa)
EDA2REctodysplasin A2 receptor. (296 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ZFAND6Uncharacterized protein. (208 aa)
CCL8C-C motif chemokine. (99 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ILKIntegrin linked kinase. (451 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
CCL14C-C motif chemokine. (95 aa)
DHX9DExH-box helicase 9. (1373 aa)
YBX3Y-box binding protein 3. (361 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
TXNDC17Thioredoxin domain containing 17. (123 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
LOC101081599SCY domain-containing protein. (158 aa)
CACTINCactin, spliceosome C complex subunit. (754 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (357 aa)
CCL13C-C motif chemokine. (98 aa)
FOXO3Forkhead box O3. (672 aa)
CDIP1Cell death inducing p53 target 1. (370 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CIB1Calcium and integrin binding 1. (191 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
FASUncharacterized protein. (314 aa)
ACTN4Actinin alpha 4. (933 aa)
SIRT1Sirtuin 1. (745 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
GSDMEGasdermin E. (495 aa)
CCL1SCY domain-containing protein. (94 aa)
ENSFCAP00000030239Uncharacterized protein. (145 aa)
ENSFCAP00000030418KH type-2 domain-containing protein. (147 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
ENSFCAP00000031202Uncharacterized protein. (94 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (542 aa)
HAS2Hyaluronan synthase 2. (552 aa)
TANKTRAF family member associated NFKB activator. (445 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1181 aa)
NPNTNephronectin. (612 aa)
LOC100302540C-C motif chemokine. (93 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TNFRSF21TNF receptor superfamily member 21. (651 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CCL22C-C motif chemokine. (93 aa)
LOC101081091C-C motif chemokine. (93 aa)
RORARAR related orphan receptor A. (523 aa)
LOC100302541C-C motif chemokine. (102 aa)
CCL7C-C motif chemokine. (99 aa)
CCL26C-C motif chemokine. (94 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
HYAL3Hyaluronidase. (419 aa)
TNFSF18TNF superfamily member 18. (178 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PID1Phosphotyrosine interaction domain containing 1. (252 aa)
TNFRSF17TNF receptor superfamily member 17. (176 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GATA3GATA binding protein 3. (444 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
TMEM130Transmembrane protein 130. (475 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
ERBINErbb2 interacting protein. (1461 aa)
ZFP36L2ZFP36 ring finger protein like 2. (705 aa)
ENSFCAP00000046520IF rod domain-containing protein; Belongs to the intermediate filament family. (148 aa)
ZFP36ZFP36 ring finger protein. (513 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
PIAS3Protein inhibitor of activated STAT 3. (652 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1600 aa)
ENSFCAP00000050587SCY domain-containing protein. (157 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
TRAF3IP2TRAF3 interacting protein 2. (567 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1566 aa)
COMMD7COMM domain-containing protein. (417 aa)
TRAF1TNF receptor-associated factor. (433 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (625 aa)
LOC101090625AN1-type domain-containing protein. (195 aa)
ENSFCAP00000052225C-C motif chemokine. (80 aa)
LRRC7Leucine rich repeat containing 7. (1575 aa)
NKX3-1NK3 homeobox 1. (231 aa)
TNFRSF13CTNF receptor superfamily member 13C. (364 aa)
ENSFCAP00000055090Uncharacterized protein. (94 aa)
ENSFCAP00000057420Uncharacterized protein. (443 aa)
TNFRSF11ATNF receptor superfamily member 11a. (638 aa)
ENSFCAP00000059874IF rod domain-containing protein; Belongs to the intermediate filament family. (136 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (525 aa)
CD58Uncharacterized protein. (270 aa)
TNFRSF4TNF receptor superfamily member 4. (350 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (882 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (674 aa)
CCL19C-C motif chemokine. (115 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (449 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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