STRINGSTRING
CA2 CA2 STAT5A STAT5A USF1 USF1 INSIG2 INSIG2 SLC27A4 SLC27A4 GRB14 GRB14 AKT2 AKT2 INPP5K INPP5K ENPP1 ENPP1 WDTC1 WDTC1 NDEL1 NDEL1 ADCY6 ADCY6 NR4A1 NR4A1 PCK1 PCK1 AGTR1 AGTR1 IRS4 IRS4 SHC1 SHC1 SLC39A14 SLC39A14 GLP2R GLP2R DENND4C DENND4C JAK1 JAK1 PDPK1 PDPK1 STAT5B STAT5B STAT3 STAT3 GHRHR GHRHR EPRS1 EPRS1 MAS1 MAS1 POU4F2 POU4F2 SLC2A4 SLC2A4 DNAI1 DNAI1 GH1 GH1 AKT3 AKT3 PRKCD PRKCD PTPN1 PTPN1 KAT2B KAT2B AKT1 AKT1 AHCYL1 AHCYL1 PARP1 PARP1 GLP1R GLP1R JAK3 JAK3 LHCGR LHCGR TYK2 TYK2 PHIP PHIP PDK2 PDK2 CSRP3 CSRP3 PIK3R1 PIK3R1 GPLD1 GPLD1 GHSR GHSR NR4A2 NR4A2 GRB10 GRB10 SOGA1 SOGA1 ADIPOQ ADIPOQ AGTR2 AGTR2 STAT6 STAT6 EDN1 EDN1 SLC30A10 SLC30A10 SMARCC1 SMARCC1 OTOP1 OTOP1 GCGR GCGR TBC1D4 TBC1D4 IGF1R IGF1R LPIN2 LPIN2 SP1 SP1 LOC101081229 LOC101081229 INSRR INSRR PDK4 PDK4 RAB12 RAB12 IRS1 IRS1 SYAP1 SYAP1 CAV2 CAV2 PARP6 PARP6 SLC2A8 SLC2A8 RAB8B RAB8B LOC101100432 LOC101100432 ZDHHC7 ZDHHC7 RPS6KB1 RPS6KB1 GSK3A GSK3A GOT1 GOT1 CPEB2 CPEB2 GRB2 GRB2 ZFP36L1 ZFP36L1 RB1 RB1 PRKCI PRKCI SH2B2 SH2B2 TSHR TSHR LPIN3 LPIN3 CAV1 CAV1 INSR INSR NCOA5 NCOA5 FOXO4 FOXO4 LEP LEP BCAR3 BCAR3 APPL1 APPL1 CAPN10 CAPN10 TRARG1 TRARG1 RHOQ RHOQ LPIN1 LPIN1 TRIB3 TRIB3 PTPRA PTPRA CRADD CRADD APC APC FOXO1 FOXO1 UMODL1 UMODL1 INHBB INHBB EIF4EBP2 EIF4EBP2 EDNRA EDNRA SRC SRC INSIG1 INSIG1 CRHR1 CRHR1 XBP1 XBP1 PKM PKM PTPN2 PTPN2 PIK3R2 PIK3R2 GSK3B GSK3B GPER1 GPER1 ENSFCAP00000044386 ENSFCAP00000044386 PKLR PKLR CRHR2 CRHR2 PIK3R3 PIK3R3 IRS2 IRS2 PCK2 PCK2 STXBP4 STXBP4 C2CD5 C2CD5 ZNF106 ZNF106 NR4A3 NR4A3 RELA RELA MGARP MGARP JAK2 JAK2 ACTN2 ACTN2 LOC101097790 LOC101097790 RAB13 RAB13 PPARG PPARG RAB15 RAB15 RARRES2 RARRES2 SLC2A1 SLC2A1 SLC27A1 SLC27A1 RAB10 RAB10 RAB31 RAB31 ANKRD26 ANKRD26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (263 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
USF1Upstream transcription factor 1. (444 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
SLC27A4Solute carrier family 27 member 4. (691 aa)
GRB14Growth factor receptor bound protein 14. (717 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (525 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
WDTC1WD and tetratricopeptide repeats 1. (700 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (480 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
SHC1SHC adaptor protein 1. (566 aa)
SLC39A14Solute carrier family 39 member 14. (491 aa)
GLP2RGlucagon like peptide 2 receptor. (373 aa)
DENND4CDENN domain containing 4C. (1957 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1576 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
POU4F2POU domain protein. (408 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
DNAI1Dynein axonemal intermediate chain 1. (719 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (246 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (454 aa)
JAK3Tyrosine-protein kinase. (1232 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
PHIPPleckstrin homology domain interacting protein. (1821 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
CSRP3Cysteine and glycine rich protein 3. (271 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (873 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1657 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (362 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
SLC30A10Solute carrier family 30 member 10. (483 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1104 aa)
OTOP1Otopetrin 1. (607 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (484 aa)
TBC1D4TBC1 domain family member 4. (1297 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LPIN2Lipin 2. (936 aa)
SP1Sp1 transcription factor. (786 aa)
LOC101081229Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa)
INSRRTyrosine-protein kinase receptor. (1300 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
RAB12RAB12, member RAS oncogene family. (339 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
SYAP1Synapse associated protein 1. (358 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
SLC2A8Solute carrier family 2 member 8. (315 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
LOC101100432Uncharacterized protein. (514 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
GOT1Aspartate aminotransferase. (413 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1045 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
RB1RB transcriptional corepressor 1. (930 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
SH2B2SH2B adaptor protein 2. (679 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (770 aa)
LPIN3Lipin 3. (1036 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
NCOA5Nuclear receptor coactivator 5. (544 aa)
FOXO4Forkhead box O4. (515 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (935 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (725 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
RHOQRas homolog family member Q. (214 aa)
LPIN1Lipin 1. (976 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (826 aa)
CRADDUncharacterized protein. (398 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
FOXO1Forkhead box O1. (662 aa)
UMODL1Uromodulin like 1. (1281 aa)
INHBBInhibin subunit beta B. (407 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (142 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SRCTyrosine-protein kinase. (678 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (426 aa)
XBP1X-box binding protein 1. (383 aa)
PKMPyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). (531 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (634 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (437 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
STXBP4Uncharacterized protein. (562 aa)
C2CD5C2 calcium dependent domain containing 5. (1126 aa)
ZNF106Zinc finger protein 106. (1902 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (651 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
MGARPMitochondria localized glutamic acid rich protein. (241 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
ACTN2Actinin alpha 2. (910 aa)
LOC101097790Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
RAB13Uncharacterized protein. (203 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RAB15Uncharacterized protein. (425 aa)
RARRES2Retinoic acid receptor responder 2. (451 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
SLC27A1Solute carrier family 27 member 1. (796 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
RAB31RAB31, member RAS oncogene family. (210 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (266 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (14%) [HD]