Your Input: | |
| | LOC101093854 | C-X-C motif chemokine. (96 aa) |
| | ANXA1 | Annexin. (407 aa) |
| | ADNP2 | ADNP homeobox 2. (1223 aa) |
| | PDE4B | Phosphodiesterase. (737 aa) |
| | KLRK1 | Killer cell lectin like receptor K1. (215 aa) |
| | LOC109498011 | Uncharacterized protein. (483 aa) |
| | ESRRB | Estrogen related receptor beta. (454 aa) |
| | KCNK4 | Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (531 aa) |
| | MGST1 | Microsomal glutathione S-transferase 1. (176 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | TEAD2 | TEA domain transcription factor 2. (451 aa) |
| | SNW1 | SNW domain containing 1. (570 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (234 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (819 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (258 aa) |
| | NUGGC | Nuclear GTPase, germinal center associated. (794 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | NFKBIB | NFKB inhibitor beta. (354 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | PTRHD1 | Peptidyl-tRNA hydrolase domain containing 1. (140 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | CST11 | Cystatin 11. (138 aa) |
| | DAXX | Death domain associated protein. (748 aa) |
| | SSTR5 | Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | GRAMD1B | GRAM domain containing 1B. (877 aa) |
| | TTC6 | TPR_REGION domain-containing protein. (1880 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | SSTR2 | Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | BPI | Bactericidal permeability increasing protein. (654 aa) |
| | MYOD1 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa) |
| | AHR | Uncharacterized protein. (849 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa) |
| | ABL2 | Tyrosine-protein kinase. (1160 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (422 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | CCDC62 | Coiled-coil domain containing 62. (687 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | LOC111556172 | Uncharacterized protein. (536 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (785 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | AR | Androgen receptor. (903 aa) |
| | SHPK | FGGY_N domain-containing protein. (478 aa) |
| | HOXA2 | Homeobox A2. (376 aa) |
| | NRIP1 | Nuclear receptor interacting protein 1. (1155 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1323 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | FCAR | Ig domain-containing protein. (176 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | UCP1 | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) |
| | CD274 | CD274 molecule. (297 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (302 aa) |
| | NPAS4 | Neuronal PAS domain protein 4. (800 aa) |
| | SSTR1 | Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | CD80 | B-lymphocyte activation antigen B7-1 (CD80). (292 aa) |
| | PTK7 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa) |
| | BPIFC | BPI fold containing family C. (507 aa) |
| | PADI2 | Peptidyl arginine deiminase 2. (665 aa) |
| | FBXO32 | F-box protein 32. (355 aa) |
| | KDM3A | Lysine demethylase 3A. (1324 aa) |
| | RXRG | Retinoid X receptor gamma. (463 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (397 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (873 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (618 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1066 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | AUNIP | Progestin and adipoQ receptor family member 7. (739 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (635 aa) |
| | RET | Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa) |
| | TFPI | Tissue factor pathway inhibitor. (331 aa) |
| | CLEC17A | C-type lectin domain containing 17A. (367 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | CD6 | CD6 molecule. (678 aa) |
| | MSN | Moesin. (577 aa) |
| | MALT1 | MALT1 paracaspase. (848 aa) |
| | SYK | Spleen associated tyrosine kinase. (636 aa) |
| | NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13. (144 aa) |
| | HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa) |
| | CXCL6 | C-X-C motif chemokine. (148 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1412 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (319 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | MSTN | Myostatin. (375 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1282 aa) |
| | NR3C2 | Nuclear receptor subfamily 3 group C member 2. (987 aa) |
| | PDK4 | Protein-serine/threonine kinase. (412 aa) |
| | M3WTU8_FELCA | Uncharacterized protein. (84 aa) |
| | LDOC1 | LDOC1 regulator of NFKB signaling. (146 aa) |
| | RUSC1 | RUN and SH3 domain containing 1. (907 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (231 aa) |
| | GRAMD1C | GRAM domain containing 1C. (664 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) |
| | TWF2 | Twinfilin actin binding protein 2. (349 aa) |
| | NR3C1 | Uncharacterized protein. (843 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | SSTR4 | Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | OSR1 | Odd-skipped related transcription factor 1. (267 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | ESRRA | Estrogen related receptor alpha. (506 aa) |
| | TMF1 | TATA element modulatory factor 1. (1093 aa) |
| | PIM1 | Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] (313 aa) |
| | VDR | Vitamin D receptor. (441 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (754 aa) |
| | M3X5D6_FELCA | Uncharacterized protein. (92 aa) |
| | HNF4G | Hepatocyte nuclear factor 4 gamma. (462 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | URI1 | URI1 prefoldin like chaperone. (533 aa) |
| | LYN | Tyrosine-protein kinase. (526 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) |
| | SELENOS | Selenoprotein S. (188 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (834 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | M3XCZ6_FELCA | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | CRHBP | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (442 aa) |
| | BRINP3 | BMP/retinoic acid inducible neural specific 3. (766 aa) |
| | PAQR8 | Progestin and adipoQ receptor family member 8. (402 aa) |
| | PLAA | Phospholipase A2 activating protein. (796 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | IL36RN | Interleukin-1. (196 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | ENSFCAP00000026456 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (128 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | LOC101087401 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (436 aa) |
| | CCR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | DDX17 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (282 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (280 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | MYOG | Myogenin. (249 aa) |
| | AQP1 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (310 aa) |
| | GPBAR1 | G protein-coupled bile acid receptor 1. (330 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | MEF2C | MADS-box domain-containing protein. (483 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | SMYD3 | SET and MYND domain containing 3. (428 aa) |
| | SETX | Senataxin. (2669 aa) |
| | FDX1 | Ferredoxin 1. (186 aa) |
| | LOC100302540 | C-C motif chemokine. (93 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | SAFB | Scaffold attachment factor B. (918 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | AXL | AXL receptor tyrosine kinase. (861 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | CXCL11 | C-X-C motif chemokine. (100 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (166 aa) |
| | BRINP1 | BMP/retinoic acid inducible neural specific 1. (761 aa) |
| | ZNF703 | Zinc finger protein 703. (592 aa) |
| | RORA | RAR related orphan receptor A. (523 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa) |
| | TFAP4 | Transcription factor AP-4. (337 aa) |
| | ENSFCAP00000040772 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (224 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (400 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | RAMP3 | Receptor activity modifying protein 3. (150 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | XBP1 | X-box binding protein 1. (383 aa) |
| | BRINP2 | BMP/retinoic acid inducible neural specific 2. (784 aa) |
| | REST | RE1 silencing transcription factor. (1045 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | PHB | Prohibitin. (272 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | ESR2 | Estrogen receptor 2. (574 aa) |
| | ENSFCAP00000042577 | DUF4939 domain-containing protein. (113 aa) |
| | SPHK2 | DAGKc domain-containing protein. (660 aa) |
| | EIF4E | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | PID1 | Phosphotyrosine interaction domain containing 1. (252 aa) |
| | LOC101085801 | Uncharacterized protein. (467 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (247 aa) |
| | PTCH1 | Patched 1. (1451 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2284 aa) |
| | LOC101094096 | C-X-C motif chemokine. (104 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | SPP1 | Secreted phosphoprotein 1. (299 aa) |
| | FAM210B | Family with sequence similarity 210 member B. (192 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (705 aa) |
| | ENSFCAP00000045932 | Uncharacterized protein. (123 aa) |
| | SOX9 | SRY-box transcription factor 9. (511 aa) |
| | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa) |
| | ZFP36 | ZFP36 ring finger protein. (513 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | ID3 | Inhibitor of DNA binding 3, HLH protein. (119 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (372 aa) |
| | PLSCR4 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (356 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (69 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (482 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | LITAF | Uncharacterized protein. (521 aa) |
| | MGARP | Mitochondria localized glutamic acid rich protein. (241 aa) |
| | ENSFCAP00000049367 | annotation not available (113 aa) |
| | RXRA | Retinoid X receptor alpha. (654 aa) |
| | PGR | Progesterone receptor. (932 aa) |
| | YAP1 | Yes associated protein 1. (498 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | DAXX-2 | Daxx domain-containing protein. (769 aa) |
| | MLC1 | Modulator of VRAC current 1. (373 aa) |
| | IRF8 | Interferon regulatory factor 8. (427 aa) |
| | RBFOX2 | RNA binding fox-1 homolog 2. (484 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | LDLR | Low density lipoprotein receptor. (866 aa) |
| | NFE2L1 | Nuclear factor, erythroid 2 like 1. (880 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | MRC1 | Mannose receptor C-type 1. (1484 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (498 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (625 aa) |
| | TRIP4 | Thyroid hormone receptor interactor 4. (605 aa) |
| | NKX3-1 | NK3 homeobox 1. (231 aa) |
| | BHMG1 | Basic helix-loop-helix and HMG-box containing 1. (591 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (869 aa) |
| | CXCL13 | C-X-C motif chemokine. (120 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (899 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1006 aa) |
| | OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (956 aa) |
| | IL36G | Interleukin-1. (219 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (376 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | RORC | RAR related orphan receptor C. (518 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (248 aa) |
| | CALCOCO1 | Calcium binding and coiled-coil domain 1. (683 aa) |
| | ARID5A | AT-rich interaction domain 5A. (608 aa) |
| | INSIG2 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa) |
| | LOC101094344 | C-X-C motif chemokine. (113 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1352 aa) |
| | NFKBIL1 | NFKB inhibitor like 1. (455 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (804 aa) |
| | ESRRG | Estrogen related receptor gamma. (506 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1162 aa) |
| | SCN1B | GRAM domain containing 1A. (923 aa) |
| | ENSFCAP00000059417 | CLLAC domain-containing protein. (134 aa) |
| | ADCY5 | Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa) |
| | CD86 | B-lymphocyte activation antigen B7-2 (CD86). (332 aa) |
| | LOC101101073 | Uncharacterized protein. (971 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (477 aa) |
| | LBP | Lipopolysaccharide binding protein. (497 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa) |
