26 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	FAS	Uncharacterized protein. (314 aa)
	KIFAP3	Kinesin associated protein 3. (793 aa)
	PKN1	Protein kinase N1. (1064 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
	CHEK2	Checkpoint kinase 2. (569 aa)
	BBC3	Uncharacterized protein. (193 aa)
	PLEKHO2	PH domain-containing protein. (486 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	BCL11B	Uncharacterized protein. (895 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (567 aa)
	NF1	Neurofibromin 1. (2856 aa)
	ADA	Adenosine deaminase. (431 aa)
	BAK1	BCL2 antagonist/killer 1. (251 aa)
	FNIP1	Folliculin interacting protein 1. (1169 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (342 aa)
	IL2RA	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	LMBR1L	Limb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BAX	ENSFCAP00000059499	ENSFCAP00000000237	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.866
BAK1	BBC3	ENSFCAP00000059499	ENSFCAP00000046125	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.820
BAK1	BCL2L11	ENSFCAP00000059499	ENSFCAP00000049779	BCL2 antagonist/killer 1.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.951
BAK1	TP53	ENSFCAP00000059499	ENSFCAP00000045749	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.739
BAX	BAK1	ENSFCAP00000000237	ENSFCAP00000059499	BCL2 associated X, apoptosis regulator.	BCL2 antagonist/killer 1.	0.866
BAX	BBC3	ENSFCAP00000000237	ENSFCAP00000046125	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.742
BAX	BCL2L11	ENSFCAP00000000237	ENSFCAP00000049779	BCL2 associated X, apoptosis regulator.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.969
BAX	TP53	ENSFCAP00000000237	ENSFCAP00000045749	BCL2 associated X, apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.411
BBC3	BAK1	ENSFCAP00000046125	ENSFCAP00000059499	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.820
BBC3	BAX	ENSFCAP00000046125	ENSFCAP00000000237	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.742
BBC3	BCL2L11	ENSFCAP00000046125	ENSFCAP00000049779	Uncharacterized protein.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.662
BBC3	TP53	ENSFCAP00000046125	ENSFCAP00000045749	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.686
BCL10	TRAF3IP2	ENSFCAP00000050608	ENSFCAP00000051222	BCL10 immune signaling adaptor.	TRAF3 interacting protein 2.	0.519
BCL2L11	BAK1	ENSFCAP00000049779	ENSFCAP00000059499	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BCL2 antagonist/killer 1.	0.951
BCL2L11	BAX	ENSFCAP00000049779	ENSFCAP00000000237	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BCL2 associated X, apoptosis regulator.	0.969
BCL2L11	BBC3	ENSFCAP00000049779	ENSFCAP00000046125	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Uncharacterized protein.	0.662
BCL2L11	FASLG	ENSFCAP00000049779	ENSFCAP00000033003	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...]	0.521
BCL2L11	TP53	ENSFCAP00000049779	ENSFCAP00000045749	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.402
CHEK2	TP53	ENSFCAP00000047524	ENSFCAP00000045749	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.952
FAS	FASLG	ENSFCAP00000026574	ENSFCAP00000033003	Uncharacterized protein.	Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...]	0.999