55 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	GBA	Glucosylceramidase. (536 aa)
	CTC1	CST telomere replication complex component 1. (1218 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
	TRIM71	Tripartite motif containing 71. (874 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (395 aa)
	SCRG1	Stimulator of chondrogenesis 1. (98 aa)
	IFT20	Intraflagellar transport 20. (158 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
	TBX3	T-box transcription factor 3. (745 aa)
	RUNX2	RUNX family transcription factor 2. (584 aa)
	OVOL1	Ovo like transcriptional repressor 1. (415 aa)
	SHB	SH2 domain-containing protein. (508 aa)
	HOXA3	Homeobox A3. (441 aa)
	SOX9	SRY-box transcription factor 9. (511 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	PTCH1	Patched 1. (1451 aa)
	SART3	Spliceosome associated factor 3, U4/U6 recycling protein. (982 aa)
	HMX2	H6 family homeobox 2. (413 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	SFRP2	Secreted frizzled related protein 2. (385 aa)
	BABAM1	Uncharacterized protein. (334 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	RNF43	RING-type domain-containing protein. (782 aa)
	CD109	CD109 molecule. (1446 aa)
	LIG4	DNA ligase. (911 aa)
	AXIN2	Axin 2. (841 aa)
	ZNRF3	Zinc and ring finger 3. (1087 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ETV6	ETS variant 6. (429 aa)
	BRCA2	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
	KDF1	Keratinocyte differentiation factor 1. (397 aa)
	BYSL	Bystin like. (436 aa)
	IRF6	Interferon regulatory factor 6. (480 aa)
	YJEFN3	YjeF N-terminal domain-containing protein. (250 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	YAP1	Yes associated protein 1. (498 aa)
	RARG	Retinoic acid receptor gamma. (459 aa)
	OPRD1	YTH N6-methyladenosine RNA binding protein 2. (600 aa)
	XRCC5	X-ray repair cross complementing 5. (747 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	NF1	Neurofibromin 1. (2856 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1733 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (501 aa)
	CEP120	Centrosomal protein 120. (987 aa)
	HOXB4	Homeobox domain-containing protein. (248 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (252 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH2	NR2E1	ENSFCAP00000057461	ENSFCAP00000002080	RBR-type E3 ubiquitin transferase.	Nuclear receptor subfamily 2 group E member 1.	0.530
AXIN2	PTCH1	ENSFCAP00000023664	ENSFCAP00000044951	Axin 2.	Patched 1.	0.422
AXIN2	RNF43	ENSFCAP00000023664	ENSFCAP00000026166	Axin 2.	RING-type domain-containing protein.	0.564
AXIN2	RUNX2	ENSFCAP00000023664	ENSFCAP00000048912	Axin 2.	RUNX family transcription factor 2.	0.503
AXIN2	SFRP2	ENSFCAP00000023664	ENSFCAP00000040067	Axin 2.	Secreted frizzled related protein 2.	0.571
AXIN2	SOX9	ENSFCAP00000023664	ENSFCAP00000045943	Axin 2.	SRY-box transcription factor 9.	0.549
AXIN2	TP53	ENSFCAP00000023664	ENSFCAP00000045749	Axin 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.436
AXIN2	WNT1	ENSFCAP00000023664	ENSFCAP00000000081	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.762
AXIN2	WNT10B	ENSFCAP00000023664	ENSFCAP00000041973	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.578
AXIN2	WNT11	ENSFCAP00000023664	ENSFCAP00000020288	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.627
AXIN2	WNT2B	ENSFCAP00000023664	ENSFCAP00000045759	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.675
AXIN2	ZNRF3	ENSFCAP00000023664	ENSFCAP00000023021	Axin 2.	Zinc and ring finger 3.	0.520
BABAM1	BRCA2	ENSFCAP00000040040	ENSFCAP00000019777	Uncharacterized protein.	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	0.420
BRCA2	BABAM1	ENSFCAP00000019777	ENSFCAP00000040040	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	Uncharacterized protein.	0.420
BRCA2	ERCC2	ENSFCAP00000019777	ENSFCAP00000002466	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.542
BRCA2	LIG4	ENSFCAP00000019777	ENSFCAP00000023705	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	DNA ligase.	0.709
BRCA2	NF1	ENSFCAP00000019777	ENSFCAP00000055600	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	Neurofibromin 1.	0.506
BRCA2	TP53	ENSFCAP00000019777	ENSFCAP00000045749	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.879
BRCA2	TP63	ENSFCAP00000019777	ENSFCAP00000027896	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.438
BRCA2	XRCC5	ENSFCAP00000019777	ENSFCAP00000053209	Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]	X-ray repair cross complementing 5.	0.596