Your Input: | |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | ANKRD17 | Ankyrin repeat domain 17. (2608 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (761 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa) |
| | PBK | PDZ binding kinase. (337 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | INO80 | INO80 complex ATPase subunit. (1620 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | RAB11B | RAB11B, member RAS oncogene family. (218 aa) |
| | KLHL18 | Kelch like family member 18. (574 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | PLRG1 | Pleiotropic regulator 1. (515 aa) |
| | NDC80 | NDC80 kinetochore complex component. (647 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1171 aa) |
| | M3WSW9_FELCA | Uncharacterized protein. (162 aa) |
| | ATRX | ATRX chromatin remodeler. (2486 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | E2F8 | E2F transcription factor 8. (864 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (522 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | SOX15 | SRY-box 15. (233 aa) |
| | RACGAP1 | Rac GTPase activating protein 1. (668 aa) |
| | THOC5 | THO complex 5. (683 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1139 aa) |
| | TBX2 | T-box transcription factor 2. (713 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | EREG | Epiregulin. (169 aa) |
| | VPS4B | Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | ANKRD31 | ANK_REP_REGION domain-containing protein. (714 aa) |
| | DBF4 | DBF4 zinc finger. (676 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1015 aa) |
| | CDC25C | Cell division cycle 25C. (477 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (350 aa) |
| | RAD51C | RAD51 paralog C. (362 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (438 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (657 aa) |
| | CEP295 | Centrosomal protein 295. (2534 aa) |
| | CDC7 | Cell division cycle 7. (574 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | THOC1 | THO complex 1. (757 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | CDCA5 | Cell division cycle associated 5. (252 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa) |
| | CDC23 | Cell division cycle 23. (547 aa) |
| | APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa) |
| | CIT | Citron rho-interacting serine/threonine kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1882 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | OOEP | Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family. (149 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1893 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (312 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (955 aa) |
| | NRM | Nurim. (262 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa) |
| | CPSF3 | Cleavage and polyadenylation specific factor 3. (684 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | SPHK1 | Sphingosine kinase 1. (473 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (916 aa) |
| | CENPJ | Centromere protein J. (1354 aa) |
| | CDC42 | Uncharacterized protein. (191 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | SPAG5 | Sperm associated antigen 5. (1194 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa) |
| | CDC25A | Cell division cycle 25A. (524 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (594 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2135 aa) |
| | AIF1 | Allograft inflammatory factor 1. (157 aa) |
| | SVIL | Supervillin. (2361 aa) |
| | FAM178B | Uncharacterized protein. (169 aa) |
| | RAB11A | RAB11A, member RAS oncogene family. (217 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa) |
| | UBXN2B | UBX domain protein 2B. (440 aa) |
| | CDC25B | Cell division cycle 25B. (578 aa) |
| | EIF4EBP3 | ANK_REP_REGION domain-containing protein. (2635 aa) |
| | DMRT1 | Doublesex and mab-3 related transcription factor 1. (378 aa) |
| | DDX39A | DExD-box helicase 39A. (518 aa) |
| | CSPP1 | Centrosome and spindle pole associated protein 1. (1226 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (674 aa) |
| | ANXA1 | Annexin. (407 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (306 aa) |
| | ENSFCAP00000060774 | Protein kinase domain-containing protein. (78 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (550 aa) |
| | LOC101088142 | GFA domain-containing protein. (262 aa) |
| | CEP120 | Centrosomal protein 120. (987 aa) |
| | CENPV | GFA domain-containing protein. (297 aa) |
| | LSM10 | LSM10, U7 small nuclear RNA associated. (123 aa) |
| | ENSFCAP00000056502 | Uncharacterized protein. (421 aa) |
| | NEUROG1 | Neurogenin 1. (243 aa) |
| | SIRT2 | Sirtuin 2. (497 aa) |
| | CDC14A | Cell division cycle 14A. (598 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (376 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (641 aa) |
| | LSM11 | LSM11, U7 small nuclear RNA associated. (399 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (899 aa) |
| | ENSFCAP00000054808 | Uncharacterized protein. (786 aa) |
| | BHMG1 | Basic helix-loop-helix and HMG-box containing 1. (591 aa) |
| | MTBP | MDM2 binding protein. (911 aa) |
| | NSFL1C | NSFL1 cofactor. (470 aa) |
| | ENSFCAP00000053720 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (114 aa) |
| | DYNC1H1 | Dynein cytoplasmic 1 heavy chain 1. (4670 aa) |
| | CDC27 | Cell division cycle 27. (839 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (408 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (602 aa) |
| | GPSM2 | G protein signaling modulator 2. (767 aa) |
| | HOXA13 | Homeobox A13. (389 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | PRDM7 | Uncharacterized protein. (918 aa) |
| | PCID2 | PCI domain containing 2. (399 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa) |
| | TFDP1 | Transcription factor. (423 aa) |
| | MSX1 | Msh homeobox 1. (303 aa) |
| | DBF4B | DBF4-type domain-containing protein. (307 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (337 aa) |
| | PLK4 | Polo like kinase 4. (969 aa) |
| | STXBP4 | Uncharacterized protein. (562 aa) |
| | NUDT16 | Nudix hydrolase 16. (195 aa) |
| | MAP3K20 | Uncharacterized protein. (800 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (701 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | ENSFCAP00000044386 | Uncharacterized protein. (156 aa) |
| | STOX1 | Storkhead box 1. (878 aa) |
| | NPM2 | Nucleophosmin/nucleoplasmin 2. (249 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | NUSAP1 | Nucleolar and spindle associated protein 1. (446 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | STIL | STIL centriolar assembly protein. (1302 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | MEPCE | Methylphosphate capping enzyme. (689 aa) |
| | E2F7 | E2F transcription factor 7. (910 aa) |
| | PPP1R35 | Protein phosphatase 1 regulatory subunit 35. (266 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (857 aa) |
| | CRNN | Cornulin. (541 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2498 aa) |
| | SH2B1 | SH2B adaptor protein 1. (757 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | MAP10 | Microtubule associated protein 10. (902 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (393 aa) |
| | KMT2E | Lysine methyltransferase 2E. (1859 aa) |
| | GLI1 | GLI family zinc finger 1. (1105 aa) |
| | NUP62CL | Nsp1_C domain-containing protein. (215 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | RAD51B | RAD51 paralog B. (350 aa) |
| | TGFA | Transforming growth factor alpha. (192 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | ECT2 | Epithelial cell transforming 2. (914 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | SMC2 | Structural maintenance of chromosomes 2. (1156 aa) |
| | BTC | Betacellulin. (194 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (221 aa) |
| | GIPC2 | GIPC PDZ domain containing family member 2. (313 aa) |
| | CDC14B | Uncharacterized protein. (529 aa) |
| | ENSFCAP00000030965 | Protein kinase domain-containing protein. (104 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1381 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | ENSFCAP00000028934 | Uncharacterized protein. (225 aa) |
| | DDX39B | DExD-box helicase 39B. (428 aa) |
| | FBXO42 | F-box protein 42. (717 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1103 aa) |
| | RANBP1 | RAN binding protein 1. (278 aa) |
| | ENSFCAP00000026963 | Uncharacterized protein. (73 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (911 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | ZNF112 | Uncharacterized protein. (915 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | CDC42-2 | Uncharacterized protein. (191 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa) |
| | NCAPH2 | Non-SMC condensin II complex subunit H2. (653 aa) |
| | BECN1 | Beclin 1. (448 aa) |
| | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (447 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (891 aa) |
